1989 Fiscal Year Final Research Report Summary
Clinical Application of Dipole Tracing Method Estimating Electric Generator Source in the Brain.
| Project/Area Number |
01044026
|
|---|
| Research Category |
Grant-in-Aid for Overseas Scientific Survey.
|
| Allocation Type | Single-year Grants |
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
HOMMA Saburo Chiba University, Emeritus Professor, 名誉教授 (70009075)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
BLOM Siegfrid Dept. Clin. Neurophysiol., Univ. Hospital Uppsala, Prof., 臨床神経生理, 教授
HAGBARTH Karl-Erik Dept. Clin. Neurophysiol., Univ. Hospital Uppsala, Prof., 臨床神経生理, 教授
MUSHA Toshimitsu Department of Applied Electronics, Tokyo Institute of Technology, Prof., 総合理工, 教授 (70016319)
NAKAJIMA Yoshio Department of Physiology, Chiba University, Professor, 医学部, 教授 (60092079)
|
|---|
| Project Period (FY) |
1989
|
| Keywords | Dipole Tracing Method / Epileptic Potential / Generator Mechanism / Hippocampus / Correction Factor / Source Localization |
|---|
| Research Abstract |
Using the Dipole Tracing System, which we have developed and is non-invasive method to estimate electrical sources in the human brain from conventional EEG recordings, we have performed research works on three patients suffering from intractable epileptic seizure in University Hospital Uppsala, Sweden. The following findings were obtained from the research works.
We have estimated dipole locations and vector moments of interictal convexity sharp waves recorded (with conventional EEG technique) from the right fronto-temporal region in a patient with partial complex seizures. When the dipole locations in the head model were compared to MRI scans, the majority of the sharp wave dipoles were found to be located in the right hippocampal area. Previous long-term subdural recording had shown seizure onset in this area. These findings will be published in Neuroscience Letters in 1990.
We have obtained correction factors from three-dimensional X-ray images of the subdural electrodes and estimated locations of the dipoles artificially elicited on the subdural electrodes. These findings will be published in IEEE Transaction of Biomedical Engineering in 1990.
|
