• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1990 Fiscal Year Final Research Report Summary

Multilateral Studies on Biologically Active Natural Substances

Research Project

Project/Area Number 01303003
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 天然物有機化学
Research InstitutionTohoku University

Principal Investigator

UDA Hisashi  Tohoku Univ. Chem. Res. Inst. of Professor Non-Aq. Solu., 非水溶液化学研究所, 教授 (40006292)

Co-Investigator(Kenkyū-buntansha) TOKOROYAMA Takashi  Osaka City Univ. Dept. of Chem. Professor, 理学部, 教授 (90046938)
YAMADA Kiyoyuki  Nagoya Univ. Dept. of Chem. Professor, 理学部, 教授 (90022540)
KAKISAWA Hiroshi  Univ. of Tsukuba Dept. of Chem. Professor, 化学系, 教授 (50015492)
HIRAMA Masahiro  Tohoku Univ. Dept. of Chem. Professor, 理学部, 教授 (30165203)
SHIRAHAMA Haruhisa  Hokkaido Univ. Dept. of Chem. Professor, 理学部, 教授 (00000802)
Project Period (FY) 1989 – 1990
KeywordsBiologically active substance / Structural determination / Total synthesis / Terpenoid / Alkaloid / Iridoid / Secosteroid / Peptide
Research Abstract

The studies have been carried out by dividing two research groups.
1. Isolations, structures, and biobeneses of biologically active natural substances : Several terpenoids, secosteroids, and alkaloids, possessing cytotoxic, antibacterial, or antiflammatory activities, have been isolated from the marine molluscs, such as soft corals and sponges, and determined their chemical structures. A neurotoxic peptide from the venom of Cyphononyx dorsalis, The neuroexcitatory amino acids and the antitumor lanostanoids from two Kinds of mushrooms, the antibactrial macrolides from Streptomyces strain, and a growth regulatory substance from rice husk have been also isolated and the structures have been elucidated. Furthermore, the enzymatic cyclization process of laurendiol to the ether-containing derivatives and the coordination of geranyl diphosphate with magnesium ion and the stereoselective elimination of a hydrogen from geranyl diphosphate have been clarified.
2. Synthetic reactions, syntheses, and action mechanisms of biologically active natural substances : For the synthesis of terpenoids and iridolids, possessing biologically active properties, such as antitumor, antibacterial etc, new synthetic reactions and synthetically useful blocks have been developed, and the total synthesis of about ten terpenoids and about six iridoiss have been accomplished. And also, lampteroflavin, a mushroom light emitter, the peptides as the plausible active center of vancomycin, an antibiotic, the lipopolysaccharide parts in the constituents of grampositive bacteria, and the key intermediate for the synthesis of tetrodotoxin have been synthesized. Furthermore, the characteristic of the alkylation of nucleosides by dehydromonocrotaline and the mode of aromatization of an enyne-3-cumulene derivative as a model of neocarzinostatin chromophore have been clarified.

  • Research Products

    (127 results)

All Other

All Publications (127 results)

  • [Publications] Akio Fukuzawa: "Laureoxolane,a New Bromo Ether from Laurencia nipponica" Tetrahedron Lett.30. 3665-3668 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akio Fukuzawa: "A Sesquiterpene Alcohol from the Red Alqa Laurencia nipponica Yamada" Phytochemistry. 29. 2337-2339 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akio Fukuzawa: "A Direct Enzymatic Synthesis of Laurencin fron Laurediol" Chem.Lett.1579-1580 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akio Fukuzawa: "Structure Elucidation of Laurenoxanyne,A New Nonisopreoid C_<15> Enyne,Using Lactoperoxidase" Tetrahedron Lett.31. 4895-4898 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masaru Hashimoto: "The Absolute Configuration of 4,6ーDecadiynー1,3,8ーtriol Isolated from Gymmopilus spectabilis" Bull.Chem.Soc.Jpn.62. 2751-2752 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushi Hiroyama: "4ーAminopyrdineー2,3ーdicarboxylic Acid from Clitocybe acromelalga" Phytochemistry. 28. 1133-1135 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimiko Hashimoto: "Simple Analogs of Acromeric Acid,which are Highly Active Agonists of Kainate Type Neuroexcitant" Tetrahedron Lett.31. 7047-7050 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimiko Hashimoto: "Synthesis of New Acromeric Congeners:Novel Neuroーexcitatory Amino Acids Acting on Glutamate Receptor" Tetrahedron Lett.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masahiro Hirama: "The 10ーMembered Rinq Analoues of Neocarzinostatin Chromophore:Design,Synthesis,and Mode of Decomposition" J.Am.Chem.Soc.111. 4120-4122 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toshiyuki Tanaka: "Oxidative Triggering for Aromatization of the Neoーcarzinostatin Chromophore" Tetrahedron Lett. 31. 5947-5950 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kenshu Fujiwara: "Enyne 3 cumulene.Synthesis and Mode of Aromatization" J.Org.Chem.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Michiharu Kato: "Stereoselective Synthesis of Natural transーPyrrolidines from Phroglutamic Acid" J.Chem.Soc.,Perkin Trans.1.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hisahiro Hagiwara: "A Synthesis of (±)ーKhusilal" Chem.Lett.2067-2068 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hisahiro Hagiwara: "Asynnetric Twoーfold Michael Reaction.Synthesis of Optically Active 4ーSubstituted 1ーDecalones from Triーmethylsilyl Enol Ether of 1ーAcetylcyclohexene" Chem.Lett.2149-2152 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nobuyuki Harada: "Efficient Preparation of Optically Pure WielandーMiescher Ketone and Confirmation of Its Absolute Stereochemistry by the CD Exciton Chirality Method" Synthesis. 53-56 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nobuyuki Harada: "Total Synthesis and Absolute Stereochemistry of (+)ーXestoquinone Xestoguinol" J.Org.Chem.55. 3158-3163 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hisahiro Hagiwara: "Total synthesis of (+)ーPerrottetianal A" J.Chem.Soc.,Perkin Trans.1. 1901-1908 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hisahiro Hagiwara: "Oneーpot Annulation to Tricyclo[5.3.1.0^<3,6>]undecanー2,6ーdiones by Sequential Three Fold Michael Reactions.A Formal Synthesis of (±)ーSeychellene" J.Chem.Soc.,Perkin Trans.1. 2109-2113 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hisahiro Hagiwara: "Total Synthesis and Absolute Stereostructure of (+)ーDysideapalaunic Acid" J.Org.Chem.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroshi Kosugi: "Total Synthesis of (+)ーNesembrine and (+)ーTrichodiene"

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroshi Kosugi: "Total Synthesis of transー(-)ーTetrahydroactinidiolide,(+)ーDihydroactinidiolide,and (-)ーNorambreinolide"

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takenori Kusumi: "A Novel Chlorinated Biscembranoid from the Marine Soft Coral Sarcophyton glaucum" J.Org.Chem.55. 6286-6289 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Midori O.Ishitsuka: "Methyl Sarcoate,a Half of the Marine Biscembranoids,from the soft Coral Sarcophyton glaucum" Tetrahedron Lett.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tadahiro Kato: "Growth Regulators in Rice Husk"

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tetsuo Furuno: "Synthetic studies on Nineーmembered Ring Diterpenoids: Stereoselective Construction of Optically Active 1ーOxaspiro[2,8]undecenone Derivatives" Heterocycles. 31. 1577-1580 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sigeru Nishiyama: "Biomimetic Synthesis and Stereostructure of Kー13,a Novel Inhibitor of Angiotensin I Converting Enzyme" TeTrahedron Lett.30. 379-382 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshikazu Suzuki: "Synthetic Study on Vancomycin: Synthesis of a Macrocyclic Tetrapeptide as a Plausible Active Center in Vancomycin" Tetrahedron Lett.30. 6043-6046 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshikazu Suzuki: "Synthesis of a Bicyclic Hexapeptide as a Plausible Active Center in Vancomycin" Tetrahedron Lett.31. 4053-4056 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazuyoshi Ohashi: "The Constituents of the Venom of Cyphononyx dorsalis"

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hideaki Karaki: "Inhibitory Effect of a Toxin Okadaic Acid,Isolated from the Black Sponge on Smooth Muscle and Platelets" Br.J.Pharmacol.98. 590-596 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Daisuka Uemura: "Structure Activity Studies of the nonTPAーType Tumor Promoter Palytoxin in Swiss 3T3 Cells" Cancer Res.49. 5837-5842 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Daisuke Uemura: "Cytotoxic Alkaloids from the Marine Sponges" J.Nat.Prod.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Haruki Niwa: "Alkylation of Nucleosides by Dehyromonocrotaline,the Putative Toxic Metabolite of Carcinogenic Pyrrolizidine Alkaloid Monocrotaline" Tetrahedron Lett.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Duangchan Uyakul: "Lampteromyces Bioluminescenceーーー3.Structure of Lampteroflavin,the Ligh Emitter in the Luminous Mushroom,L.japonicus" Bioorg Chem.17. 454-460 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Minoru Isobe: "Lampteromyces Bioluminescenceーーー5.Chemical Synthesis of Lampteroflavin as Mushroom Light Emitter" Tetrahedron Lett.31. 717-718 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Minoru Isobe: "Synthetic Studies on (-)ーTetrodotoxin(3)ーーNitrogenation through Overman Rearrangement and Guanidin Ring Formation" Tetrahedron Lett.31. 3327-3330 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Herunsalee: "Stereoselective Synthesis directed toward Polyoxygenated Compounds,Synthesis of A KDN Equivalent" Synlett.199-200 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Koichi Fukase: "4ーNitrobenzyl Group for Protection of Hydroxy Functions" Tetrahedron Lett.31. 389-392 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] MingーHai Wang: "Suppressive Effect of Lipid A Partial Structure on Lipopolysaccharide or Lipid Aーinduced Release of Interleukin 1 by Human Monocytes" FEMS Microbiology Immunology. 64. 179-186 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Koichi Fukase: "4ーPivaloylaminobenzyl Group. a New Temporary Protection for Hydroxyl Functions" Tetrahedron Lett.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mugio Nishizawa: "Isolation of a New Cycloartanoid Triterpene from Leaves of Lansium domesticum,Novel Skinーtumor Promotion" Tetrahedron Lett.30. 5615-5618 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yuji Hayashi: "Malonate Halfーesters of Homolanostanoid from an Asian Ganoderma Fungus" Phytochemistry. 29. 923-928 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yuji Hayashi: "Structure of Syzygiol: a Skinーtumor Promotion Inhibitor" Tetrahedron Lett.32. 211-212 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hideo Iio: "Synthesis of cisー and transー15,16ーEpoxyclerodaー13(16),14ーdienー3ーones: Incompatibility with the Structure of Cascarillone" J.Chem.Soc.,Perkin Trans.1. 1359-1360 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hideo Iio: "Cascarillone: Revised Structure and Total Synthesis" J.Shem.Soc.,Perkin Trans.1. 1360-1361 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazuhiko Asao: "Convenient Stereoselective Synthesis of (6E)ー and (6Z)ー 5,6ーDimethy1ー8ーsilylー6ーoctanols" Synthesis. 382-386 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Tokoroyama: "Synthetic Studies on Terpenic Compounds.XXXIII.A Total Synthesis of (±)ー15,16ーEpoxyーcisーclerodaー3,13(16),14ー triene" Bull.Chem.Soc.Jpn.63. 1720-1728 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinya Fujiwara: "Stereoselective Synthesis of2ーSubstituted 1ーMethoxyー 1,3ーdienes by 1,4ーElimination with Tributylstanny1ー lithium" Tetrahedron Lett.31. 691-694 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sachihiko Isoe: "Synthesis of Allamandicin,Plumericin and Plumieride Aglycone from (+)ーGenipin"

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sachihiko Isoe: "Synthesis of Nepetalactol and Neomatatabiol from (+)ーGenipin"

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sachihiko Isoe: "Synthesis of (+)ーTecomanin from (+)ーGenipin" 発表予定.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akira Hirota: "Structure of Kaimonolide A,a Novel Macrolide Plant Growth Inhibitor from a Streptomyces Strain" Agric.Biol.Chem.53. 2831-2833 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Eiji Kitamura: "(1R,6R,9S,10S)ー9ーShloroー10ーhydroxyー8ーmethoxycarbony1ー4ーmethyleneー2,5ーdioxabicyclo[4.4.0]decー3ーoneー7ーene.A First Chlorineーcontaining Shikimateーrelated Metabolite from Fungi" Tetrahedron Lett.31. 4605-4608 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takayuki Suga: "Glycinoprenols:Novel Polyprenols Possessing a Phytyl Residue from Leaves of Soybean" J.Org.Chem.54. 3390-3393 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohru Yamamitsu: "Synthesis of 4ー and 5ーRegioselectively Deuterated Geranyl Diphosphate" J.Chem.SoC.,Perkin Trans.1. 1811-1814 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshikazu Hiraga: "Facile Synthesis of Regioselective Deuteriated (3R)ー(-)ー[8,8,8ー^2H_3]Linalool" Chem.Lett.49-52 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shunsuke Izumi: "Synthesis of [10,10,10ー^2H_3]Geranyl Diphosphate" J.Labelled Compd.Radiopharm. 印刷中.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masamitsu Ochi: "Litophynin D and E,Two New Diterpenoids from a Soft coral Litophyton sp." Chem.Lett.2183-2186 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masamitsu Ochi: "Calicoferols A and B,Two Novel Secosterols Possessing BrineーShrimp Lethalty from a Gorgonian Acathogorgiidae sp." Chem.Lett.427-430 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masamitsu Ochi: "Acanthopherol A and B,Two Novel Secosterols with Brine Shrimp Lethalty from a Gorgonian Acanthogorgiidae sp."

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitsuaki Kodama: "Convenient Synthesis of Chiral Epoxyisorenoids by Yeast Reduction" Tetrahedron Lett.31. 4025-4026 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 磯部 稔: "天然物化学の新しい展開ーその考え方と進め方" 化学同人, 166 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Daisuke Uemura: "Studies in Natural Products Chemistry,Vol.5 (PartB) attaーurーRahman, Ed." Elsevier,Amsterdam, 906 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 白濱 晴久: "生体機能解明のための化学合成 (部分担当)" 化学同人, 253 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Minoru Isode: "Ansamacrolides Recent Progress in the Chemical Synthesis of Antibiotics.Chapter 4,pp103ー134" Springer Verlag, 803 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Daisuke Uemura: "Bioorganic Marine Chemistry,Vol.4" Springer Verlag, 1-30 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akio Fukuzawa: "Laureoxolane, a new Bromo Ether from Laurencia nipponica" Tetrahedron Lett.30. 3665-3668 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akio Fukuzawa: "A Sesquiterpene Alcohol from the Red Alga Laurentia nipponica Yamada" Phytochemistry. 29. 2337-2339 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akio Fukuzawa: "A Direct Enzymatic Synthesis of Laurencin from Laurendiol" Chem. Lett. 1579-1580 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akio Fukuzawa: "Structure Elucidation of Laurenoxanyne, A new Nonisoprenoid C_<15> Enyne, Using Lactoperoxidase" Tetrahedron Lett. 31. 4895-4898 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masaru Hashimoto: "The Absolute Configuration of 4, 6-Decadiyne-1, 3, 8-triol Isolated from Gymmopilus spectabilis(/)-@DB" Bull. Chem. Soc. Jpn. 62. 2751-2752 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushi Hiroyama: "4-Aminopyridin-2, 3-dicarboxylic Acid from Clitocybe acromelalga(/)-@DB" Phytochemistry. 28. 1133-1135 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimiko Hashimoto: "Simple Analogs of Acromeric Acid, Which are Highly Active agonists of Kainate Type Neuroexcitant" Tetrahedron Lett. 31. 7047-7050 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimiko Hashimoto: "Synthesis of New Acromeric Congeners : Novel Neuroexcitatory Amino Acids Acting on Glutamate Receptor" Tetrahedron Lett.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masahiro Hirama: "The 10-Member Ring Analogues of Neocarzinostatin Chromophore : Design, Synthesis, and Mode of Decomposition" J. Am. Chem. Soc.111. 4120-4122 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toshiyuki Tanaka: "Oxidative Triggering for Aromatization of the Neocarzinostatin Chromophore" Tetrahedron Lett. 31. 5947-5950 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kenshu Fujiwara: "Enyne 3 cumulene. Synthesis and Mode of Aromatization" J. Org. Chem.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Michiuaru Kato: "Stereoselective Synthesis of Natural trans-Pyrrolidines from Pyroglutamic Acid" J. Chem. Soc., Perkin Trans. 1.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hisahiro Hagiwara: "A Synthesis of <plus-minus>-Khusil " Chem. Lett.2067-2068 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hisahiro Hagiwara: "Asymmetric Two-fold Michael Reaction. Synthesis of Optically Active 4-Substituted 1-Decalones from Trimethylsilky Enol Ether of 1-Acety1-Cyclohexene" Chem. Lett.2149-2152 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nobuyuki Harada: "Efficient Preparation of Optically Pure Wieland-Miescher Ketone and Confirmation of Its Absolute Stereochemistry by the CD Exciton Chirality Method" Synthesis. 53-56 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nobuyuki Harada: "Total Synthesis and Absolute Stereochemistry of (+)-Xestoquinone and Xestquinol" J. Org. Chem.55. 3158-3163 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hisahiro Hagiwara: "Total Synthesis of (+)-Perrottetianal A" J. Chem. Soc., Perkin Trans. 1. 1901-1908 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hisahiro Hagiwara: "One-Pot Annulation to Tricyclo[5.3.1.0^<3, 6>]undecan-2, 6-diones by Sequential Three Fold Michael Reactions. A Formal Synthesis of ([SY. +-.[)-Seychellene" J. Chem. Soc., Perkin Trans. 1. 2109-2113 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hisahiro Hagiwara: "Total Synthesis and Absolute Stereostructure of (+)-Disideapalaunic Acid" J. Org. Chem.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Kosugi: "Total Synthesis of (+)-Mesembrine and (+)-Trichodiene"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Kosugi: "Total Synthesis of trans-Tetrahydroactinidiolide, (+)-Dihydroactinidiolide, and (-)-Norambreinolide"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takanori Kusumi: "A Novel Chlorinated Biscembranoid from the Marine Soft Coral Sarcophyton glaucum" J. Org. Chem. 55. 6286-6289 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Midori O. Ishitsuka: "Methyl Sarcoate, a Half of the Marine Biscembranoids, from the Soft Coral Sarcophyton glaucum" Tetrahedron Lett.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tadahiro Kato: "Growth Regulators in Rice Husk"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tetsuo Furuno: "Synthetic Studies on Nice-membered Ring Diterpenoids : Stereoselective Construction of Optically Active 1-Oxaspiro[2, 8]undecenone Derivatives" Heterocycles. 31. 1577-1580 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sigeru Nishiyama: "Biomimetic Synthesis and Stereostructure of K-13, a Novel Inhibitor of Angiotensin I Converting Enzyme" Tetrahedron Lett. 30. 379-382 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshikazu Suzuki: "Synthetic Study on Vencomycin : Synthesis of a Macrocyclic Tetrapeptide as a Plausible Active Center in Vancomycin" Tetrahedron Lett.30. 6043-6046 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshikazu Suzuki: "Synthesis of a Bicyclic Hexapeptide as a Plausible Active Center in Vancomycin" Tetrahedron Lett. 31. 4053-4056 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kazuyoshi Ohashi: "The Constituents in the Venom of Cyphononyx dorsalis"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hideaki Karaki: "Inhibitory Effect of a Toxin Okadaic Acid, Isolated from the Black Sponge on Smooth Muscle and Platelets" Br. J. Pharmacol. 98. 590-596 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Daisuke Uemura: "Structure Activity Studies of the nonTPA-Type Tumor Promoter Palitoxin in Swiss 3T3 Cells" Cancer Res. 49. 5837-5842 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Daisuke Uemura: "Cytotoxic Alkaloids from the Marine Sponges" J. Nat. Prod.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Haruki Niwa: "Alkylation of Nucleosides by Dehydromonocrotaline, the Putative Toxic Metabolite of the Carcinogenic Pyrrolizidine Alkaloid Monocrotaline" Tetrahedron Lett.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Duangchan Uyakul: "Lampteromyces Bioluminescence--3. Structure of Lampteroflavin, the Light Emitter in the Luminous Mushroom, L. japonicus" Bioorg. Chem.17. 454-460 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Minoru Isobe: "Lampteromyces Bioluminescence---5. Chemical Synthesis of Lamptroflavin as Mushroom Light Emitter" Tetrahedron Lett. 31. 717-718 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Minoru Isobe: "Synthetic Studies on (-)-Tetrodotoxin(3)--Nitrogenation through Overman Rearrangement and Guanidin Ring Formation" Tetrahedron Lett. 31. 3327-3330 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A. Herunsalee: "Stereoselective Synthesis directed toward Polyoxygenated Compounds, Synthesis of A KDN Equivalent" Synlett. 199-200 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koichi Fukase: "4-Nitrobenzyl Group for Protection of Hydroxy Fenctions" Tetrahedron Lett. 31. 389-392 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ming-Hai Wang: "Suppressive Effect of Lipid A Partial Structure on Lipopolysaccharide or Lipid A-induced Release of Interleukin 1 by Human Monocytes" FEMS Microbiology Immunology. 64. 179-186 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koichi Fukase: "4-Pivaloylaminobenzyl Group. a New Temporary Protection for Hydroxyl Functions" Tetrahedron Lett.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mugio Nishizawa: "Isolation of a New Cycloartanoid Triterpene from Leaves of Lansium domesticum, Novel SKin-tumor Promotion Inhibitors" Tetrahedron Lett. 30. 5615-5618 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yuji Hayashi: "Malonate Half-esters of Homolanostanoid from an Asian Ganoderma Fungus" Phytochemistry. 29. 923-928 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yuji Hayashi: "Structure of Syzygiol. a Skin-tumor Promotion Inhibitor" Tetrahedron Lett. 32. 211-212 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hideo Iio: "Synthesis of cis- and trans-15, 16-Epoxycleroda-13(16), 14-dien-3-ones : Incompatibility with the Structure of Cascarillone" J. Chem. Soc., Perkin Trans. 1. 1359-1360 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hideo Iio: "Cascarillone : Revised Structure and Total Synthesis" J. Chem. Soc., Perkin Trans. 1. 1360-1361 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kazuhiko Asao: "Convenient Stereoselective Synthesis of (6E)- and (6Z)-5, 6-Dimethyl-8-silyl-6-octanols" Synthesis. 382-386 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Tokoroyama: "Synthetic Studies on Terpenic Compounds. XXXIII. A Total Synthesis of <plus-minus>-15, 16-Epoxy-cis cleroda-3, 13-(16), 14-trie " Bull. Chem. Soc. Jpn.63. 1720-1728 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinya Fujiwara: "Stereoselective Synthesis of 2-Substituted 1-Methoxy-1, 3-dienes by 1, 4-Elimination with Tributylstannyllithium" Tetrahedron Lett. 31. 691-694 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sachihiko Isoe: "Synthesis of Allamandicin, Plumericin and Plumieride Aglycone from (+)-Genipin"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sachihiko Isoe: "Synthesis of Nepetalactol and Neomatatabiol from (+)-Genipin"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sachihiko Isoe: "Synthesis of (+)-Tecomanin from (+)-Genipin"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akira Hirota: "Structure of Kaimonolide A, a Novel Macrolide Plant Growth Inhibitor from a Streptomyces Strain" Agric. Biol. Chem. 53. 2831-2833 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Eiji Kitamura: "(1R, 6R, 9S, 10S)-9-Chloro-10-hydroxy-8-methoxycarbonyl-4-methylene-2, 5-dioxabicyclo[4.4.0]dec-3-one-7-ene. A First Chlorine-Containing Shikimate-related Metabolite from Fungi" Tetrahedron Lett. 31. 4605-4608 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takayuki Suga: "Glycinoprenols : Novel Polyprenols Possessing a Phytyl Residue from the Leaves of Soybean" J. Org. Chem.54. 3390-3393 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tohru Yamamitsu: "Synthesis of 4- and 5-Regioselectively Deuterated Geranyl Diphosphate" J. Chem. Soc., Perkin Trans. 1. 1811-1814 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshikazu Hiraga: "Facile Synthesis of Regioselectively Deuteriated (3R)-(-)-[8, 8, 8-^-H_3]Linalool" Chem. Lett. 49-52 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shunsuke Izumi: "Synthesis of [10, 10, 10-^-H_3]Geranyl Diphosphate" J. Labelled Compd. Radiopharm.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masamitsu Ochi: "Litophynin D and E, Two New Diterpenoids from a Soft Coral Litophyton sp." Chem. Lett.2183-2186 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masamitsu Ochi: "Calicoferols A and B, Two Novel Secosterols Possessing Brine-Shrimp Lethality from the Gorgonian Calicogorgia sp." Chem. Lett.427-430 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masamitsu Ochi: "Acanthopherol A and B, Two Novel Secosterols with Brine Shrimp Lethality from a Gorgonian Acanthogorgiidae sp."

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitsuaki Kodama: "Convenient Synthesis of Chiral Epoxyisoprenoids by Yeast Reduction" Tetrahedron Lett. 31. 4025-4026 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1993-08-12  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi