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1990 Fiscal Year Final Research Report Summary

Investigation of Senile Dementia with PET and MRI

Research Project

Project/Area Number 01440045
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

YAMADA Kenji  Tohoku Univ., Dept. of Radiol. Nucl. Med., Associate Professor, 抗酸菌病研究所, 助教授 (40134051)

Co-Investigator(Kenkyū-buntansha) ITO Masatoshi  Tohoku Univ., Cyclotron & RI Center, Associate Professor, サイクロトロンRIセンター, 助教授 (00125501)
MATSUZAWA Taiju  Tohoku Univ., Emeritus Professor, 名誉教授 (10006108)
ISHII Keizo  Tohoku Univ., Cyclotron & RI Center, Associate Professor, サイクロトロンRIセンター, 助教授 (00134065)
WATANABE Tatehiko  Tohoku Univ., Med. Dept., Professor, 医学部, 教授 (70028356)
Project Period (FY) 1989 – 1990
KeywordsBrain atrophy / Cerebral blood flow / Regional cerebral glucose metabolism / Senile dementia of Alzheimer type / Multi-infarct dementia / Positron emission tomography(PET) / Hippocampus / Amygdala
Research Abstract

In this research, we tried to extract the characters of changes from normal aging through senile dementia. The results obtained were as follows.
(1) Cerebral metabolism and aging changes on MRI.
We investigated the relationship between cerebral blood flow by PET and the periventricular hyperintensity (PVH) which is an aging change on MRI and found decreased cerebral blood flow in cases of severe PVH.
(2) Characters of formal changes in multi-infarct dementia (MID) on X-CT.
Brain atrophy progresses during aging. We revealed the characteristic widening of the inferior horns of the lateral ventricles in cases of MID unlike in normal aging.
(3) Regional cerebral glucose metabolism on PET in senile dementia of Alzheimer type (SDAT) and MID.
We assumed the common basis of functional changes in SDAT and MID which have different pathogenesis but have same clinical symptoms. We studied these functional abnormalities from the aspect of regional cerebral glucose metabolism and found common hypometabolism of glucose in the association corteces of dementia cases.
(4) Correlation between widening of the inferior horns of the lateral ventricles and decrease of regional cerebral glucose metabolism.
We investigated the relationship between the size of ventricular system and regional cerebral glucose metabolism. The results showed that widening of the inferior horns of the lateral ventricles was strongly correlated with decrease of regional cerebral glucose metabolism in cerebral corteces regardless of the type of dementia, MID or SDAT.
These results suggested that dementia was closely related to the changes in hippocampus and amygdala which constitutes the medial aspect of the inferior horns. Therefore we emphasize here the great necessity for studies of the limbic system as a focus in the investigation of dementia.

  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] 山田 健嗣,松澤 大樹: "脳の老化" 臨床画像. 5(12). 75-81 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Taiju Matsuzawa: "Analysis of dementia syndrome with XーCT,MRI and PET" Proceedings of the Japan Academy,Ser.B(1). 65. 5-8 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山口 龍生,松澤 大樹: "脳血管性痴呆に関する核医学的研究の進歩(PET)" 精神科治療学. 4(10). 1241-1247 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松澤 大樹: "痴呆と“こころ"" 東北医学雑誌. 103. 143-147 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 菱沼 隆,松澤 大樹 山田 健嗣 ほか: "MRIによる脳脊髄液T_2緩和時間測定ー加齢性変化との対比ー" 日本磁気共鳴医学会雑誌. 10(2). 106-113 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松澤 大樹: "痴呆と“こころ"" 国際医書出版, 111 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松澤 大樹: "老化と脳の萎縮(脳は老化するか)" 朝長正徳/編著,ダイヤモンド社, 222(64-91) (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Taiju Matsuzawa: "Onset of Dementia and Start of Mind" Tohoku Igaku Zasshi. 103. 143-147 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Hishinuma et al.: "Cerebrospinal Fluid Measurements of T_2 Relaxation Time with MRI -A Comparative Study with Aging-" Japanese Journal of Magnetic Resonance in Medicene. 10(2). 106-113 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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