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1990 Fiscal Year Final Research Report Summary

ヒト乳癌における増殖因子・受容体の多様性とそれに基づく治療法の開発

Research Project

Project/Area Number 01440052
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionDepartment of Surgery, School of Medicine, Keio University

Principal Investigator

ABE Osahiko  Keio Univ. Dept. Surgery, Professor, 医学部, 教授 (90051028)

Co-Investigator(Kenkyū-buntansha) ANDO Jiro  Keio Univ Dept. Surgery, 医学部, 助手 (40193106)
FUKUYAMA Ryuichi  Keio Univ. Dept. Mol. Biol., 医学部, 助手 (60199271)
Project Period (FY) 1989 – 1990
KeywordsBreast Cancer / growth factor / growth factor receptor / int-2 / erb B-2 / C-erb B-2 product
Research Abstract

We investigated the polymorphism of growth factor・receptors and their gene amplifications in breast cancer. C-erb B-2 and C-int 2 gene amplification in breast cancer were observed in high incidence such as 22%, 20% respectively. C-erb B-2 product was stained in 25% cases of breast cancer tissue by ABC staining using monoclonal antibody for recognizing the internal domain of c-erb B-2 product. To evaluate the prognostic significance of these factors, we divided the patients with breast cancer into two groups, that is, amplifiction or staining positive group and negative group in each factor, we and compared the acumulative survival curves of them. The overall survival curves of positive groups in each factor were significantly worse than those of negative group, respectively. These data means that growth factor receptor and its gene is a valuable marker to evaluated a prognosis.

  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Hirota,N.: "Suppression of an epidermal growth factor receptorーhyperproducing tumor by a immunotoxin conjugate of gelonin and a monclonalantrーEGFR antibody" Cancer Res. 49. 7106-7109 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上田 政和: "ホルモン・増殖因子とレセプタ-" 病理と臨床. 8. 167-171 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 熊 軍: "cーerbBー2癌遺伝子産物の細胞外ドメインを認識する抗体の作製とヒト乳癌の免疫組織化学的検討" 第9回腫瘍マ-カ-研究会記録別刷. 9. 48-50 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 阿部 令彦: "乳癌治療の変遷と展望ー形貭表現と治療に関する諸問題ー" Breast Cancer Today. 7. 2-9 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 清水 壮一: "Immunoconjugateの作製法ーモノクロ-ナル抗体とトキシンもしくは抗癌剤との復合体ー" Oncologid. 24. 98-100 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 菊池 潔: "悪性腫瘍における癌遺伝子の増幅及び産物からみたがん転移と再発" 日本外科学会雑誌.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirota, N., Ueda, M., Ozawa, S., Abe, O, and Shimizu, N.: "Suppression of epidermal growth factor receptor- hyperproducing tumor by an immunotoxin conjugate of gelonin and a monoclonal anti-epidermal growth factor receptor antibody." Cancer Research. 49. 7106-7109 (1989)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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