1992 Fiscal Year Final Research Report Summary
The basic studies on the diagnosis and treatment of inner ear deafness.
| Project/Area Number |
01440070
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KUSAKARI Jun Univ.of Tsukuba,Inst.Clin.Med.,Prof., 臨床医学系, 教授 (00004705)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIKAWA N Univ.of Tsukuba,Inst.Clin.Med.,Assist.Prof., 臨床医学系, 講師 (60237675)
TAKAHASHI K Univ.of Tsukuba,Inst.Clin.Med.,Assist.Prof., 臨床医学系, 講師 (70197135)
TAKEYAMA M Univ.of Tsukuba,Inst.Clin.Med.,Assist.Prof., 臨床医学系, 講師 (60179679)
ASE Y Univ.of Tsukuba,Inst.Clin.Med.,Assist.Prof., 臨床医学系, 講師 (00013920)
HARA A Univ.of Tsukuba,Inst.Clin.Med.,Associate Pro, 臨床医学系, 助教授 (10156474)
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| Project Period (FY) |
1989 – 1992
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| Keywords | Transient anoxia / Endolymphatic hydrops / Acoustic overstimulation / Olivo-cochlear bundle / Cervical sympathetic nerve / Perilympha / Trace elements |
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| Research Abstract |
Following experiments were performed using guinea pigs.
1.Transient anoxia
The animals were subjected to 1 hour anoxia by obstructing the artery. The recovery of the endocochlear potential (EP) was significantly better in animals under hypothermia or pre-treated with mannitol and phenitoin than in untreated ones.
2.Endolymphatic hydrops
The EP was decreased and the threshold of the compound action potential was elevated with the progression of the hydrops.
3.Acoustic overstimulation
Although stimulation or elimination of the superior cervical ganglion exhibited no effect, stimulation of olivo-cochlear bundle, the reduction of the EP by furosemide or the presence of endolymphatic hydropssignificantly reduced the susceptibility to acoustic overstimulation.
4.Oto-acoustic emission (OAE)
We studied how to differentiate biological response from artefacts.
5.Metallic elements (Fe,Mg,Mn,Zn etc) in the perilympha
Metallic elements in the perilympha were detected using ICP-AES. Fe was increased by anoxia and Mg was decreased by acoustic overstimulation.
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