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1990 Fiscal Year Final Research Report Summary

Development of New Chiral Transition-Metal Catalysts for Highly Efficient Asymmetric Synthesis

Research Project

Project/Area Number 01470095
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Synthetic chemistry
Research InstitutionKyoto University

Principal Investigator

TAKAYA Hidemasa  Kyoto Univ., Faculty of Engineering, Professor, 工学部, 教授 (40022644)

Co-Investigator(Kenkyū-buntansha) MASHIMA Kazushi  Kyoto Univ., Faculty of Engineering, Research Associate, 工学部, 助手 (70159143)
Project Period (FY) 1989 – 1990
KeywordsBINAP-Ru / Asymmetric Hydrogenation / Diastereoselective Hydrogenation / Mechanism / [Ru_3X_5(binap)_3]Y / [RuX(binap)(arene)]Y / X-ray analysis / Deuterium-labeled experiment
Research Abstract

We had already developed atroisomeric bis (triarylphosphine) ligand, 2, 2^'-bis (diphenylphosphino)-1, 1^'-binaphthyl (abbreviated to BINAP) and showed that its metal complexes had high efficiency as catalysts for asymmetric hydrogenation of -acylaminoacrylic acids and asymmetric isomerization of allylamines into enamines by 1, 3-hydrogen migration. We also reported synthesis of Ru (OCOR) _2 (binap), the first mononuclear BINAP-Ru (II) complexes, and demonstrated that they are highly efficient catalysts for the asymmetric hydrogenations of emanides, alpha, beta- and beta, gamma-unsaturated carboxylic acids, allylic and homoallylic alcohols. In order to expand the synthetic utility of BINAP ligand, we have continued our investigation on the development of new highly efficient asymmetric reactions catalyzed by various BINAP-Ru (II) complexes which have been summarized below.
(1) New cationic BINAP-Ru (II) complexes [RuX (binap) (arene)]y (X=Cl, Br, and I ; Y = Cl, Br, I, BF_<4'> and BPh_4 … More ; arene = benzene and p-cymene) have been synthesized in high yields and the molecular structures have been determined by spectroscopic and X-ray analyses. We have shown that these complexes are highly efficient catalysts for enantioselective hydrogenation of various unsaturated substrates. Especially important is the high efficiency of these complexes as catalysts for asymmetric hydrogenation of functionalized ketones.
(2) A number of substituted BINAP derivatives have been synthesized. Various factors controlling the catalytic activity and selectivity of the asymmetric hydrogenation of ketones have been elucidated by use of these complexes.
(3) Highly diastereoselective hydrogenation of methyl 2-benzamidomethyl-3-oxobutanoate via dynamic kinetic resolution has been accomplished by using [RuI ((R-3, 5-di-tert-Bu-binap) (p-cymene)] I as catalyst, giving methyl (2S, 3R-2-benzamidomethyl-3-hydroxybutanoate (98% 99%), a versatile intermediate intermediate for the synthesis of beta-lactam antibiotics.
(4) Mechanism of asymmetric hydrogenation of alpha,beta-unsaturated carboxylic acids catalyzed by Ru (OCOCH_3) _2 (bianp) has been elucidated based mainly on deuterium-labeled experiments.
(5) New monocationic trinuclear complexes [Ru_3X_5 (binap) _3] Y have been prepared and their roles in catalytic reactions have been discussed.
(6) Several new bis (triaryphophine) ligands have been synthesized and their use for asymmetric catalysis have been investigated. Less

  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] S.Inoue,H.Takaya,K.Tani,S.Otsuka,T.Sato,R.Noyori: "Mechanism of the Asymmetric Isomerization of Allylamines to Enamines Catalyzed by BINAPーRhodium Complexes" J.Am.Chem.Soc.112. 4897-4905 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Fukda,K.Mashima,Y.Matsumura,H.Takaya: "Synthesis of New Chiral Bis(triarylphosphine)Ligands Based on Asymmetric Hydrogenation of 4,5ーDiary1ー2ーoxocyclopentanecarboxylates" Tetrahedron Lett.31. 7185-7188 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Ohta,H.Takaya,R.Noyori: "Stereochemistry and Mechanism of the Asymmetric Hydrogenation of Unsaturated Carboxylic Acids Catalyzed by BINAPーRuthenium(II) Dicarboxylate Complexes" Tetrahedron Lett.31. 7189-7192 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Mashima,Y.Matsumura K.Kusano,H.Kumobayashi N.Sayo,Y.Hori,T.Ishizaki,S.Akutagawa H.Takaya: "Highly Steoselective Asymmetric Hydrogenation of 2ーBenzamidomethylー3ーoxobutanoate Catalyzed by Cationic BINAPーRuthenium(II)Compleses" J.Chem.Soc.,Chem.Commun.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Takaya,T.Ohta,S.Inoue,R.Noyori: "Asymmetric Hydrogenation of Allylic Alcohols Using BINAPーRuthenium Compleses" Org.Synth.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] R.Noyri,H.Takaya: "BINAP:An Efficient Chiral Element for Asymmetric Catalysis" Acc.Chem.Res.23. 345-350 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Takaya,T.Ohta,K.Mashima,M.Kitamura,R.Noyori: "In ″Future Opportunities in Catalytic Separation Technology″,New Chiral Rh(I) and Complexes: Highly Efficient Catalysts for Homogeneous Asymmetric Hydrogenation,Chapter IV.2" Elsevier,Amsterdam, 18 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K. Mashima, K. Kusano, T. Ohta, R. Noyori, and H. Takaya: "Synthesis of New Cationic BINAP-Ruthenium(II) Complexes and their Use in Asymmetric Hydrogenation [BINAP = 2, 2'-bis (diphenylphosphino)-1.1'-binaphthyl]" J. Chem. Soc., Chem. Commun.1208-1210 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A. Miyashita, H. Karino, J. Shimamura, T. Chiba, K. Nagano, H. Nohira, and H. Takaya: "Synthesis of Atropisomeric 2, 2'-Bis (dicyclohexylphosphino) -6, 6'-dimethyl-1, 1'-binaphthyl (BICHEP) and Its Use in Rh (I) -catalyzed Asymmetric Hydrogenation of Prochiral Olefins" Chem Lett.1849-1852 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] R. Noyori, T. Ikeda, T. Ohkuma, M. Widhalm, M. Kitamura, H. Takaya: "Stereoselective Hydrogenation via Dynamic Kinetic Resolution." J. Am. Chem. Soc.Vol. 111. 9134-9135 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Wang, T. Sakata, M. Azuma, T. Ohta, and H. Takaya: "Photocatalytic Asymmetric reduction of 3-Methyl-2-oxobutanoic Acid with Chiral Rh(I) Complexes and Powdery Semiconductors." Chem. Lett.,. 1331-1334 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Inoue, H. Tkaya, K. Tani, S. Otsuka, T. Sato, and R. Noyori: "Mechanism of the Asymmetric Isomerization of Allylamines to Enamines Catalyzed by BINAP-Rhodium Complexes" J. Am. Chem. Soc.Vol. 112. 4897-4905 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Fukuda. K. Mashima, Y. Matsumura, H. Takaya,: "Synthesis of New Chiral Bis (triarylphosphine) Ligands Based on Asymmetric Hydrogenation of 4, 5-Diaryl-2- oxocyclopentanecarboxylates" Tetrahedron Lett.Vol. 31. 7185-7188 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Ohta, H. Takaya, and R. Noyori: "Stereochemistry and Mechanism of the Asymmetric Hydrogenation of Unsaturated Carboxylic Acids Catalyzed by BINAP-Ruthenium(II) Dicarboxylate Complexes" Tetrahedron Lett.Vol. 31. 7189-7192 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Mashima, Y. Matsumura, K. Kusano, H. Kumobayashi, N. Sayo, Y. Hori, T. Ishizaki, S. Akutagawa, and H. Takaya: "Highly Stereoselective Asymmetric Hydrogenation of 2-Benzamidomethyl-3-oxobutanoate Catalyzed by Cationic BINAP-Ruthenium(II) Complexes" J. Chem. Soc., Chem. Commun.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Mashima, T. Hino, and H. Takaya: "Synthesis and Characterization of Cationic Trinuclear Binap-Ru (II) Complexes : Crystal Structure of [Ru_3Cl_5((S)-binap)_3]BF_4" Tetrahedron Lett.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Takaya, T. Ohta, S. Inoue, and R. Noyori: "Asymmetric Hydrogenation of Allylic Alcohols Using BINAP-Ruthenium Complexes" Org. Synth.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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