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1990 Fiscal Year Final Research Report Summary

Basic Studies on Physiological Factors in Radiocurability

Research Project

Project/Area Number 01480270
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionUniversity of Tokyo

Principal Investigator

SUZUKI Norio  University of Tokyo, Faculty of Medicine, Professor, 医学部・医学科, 教授 (10010050)

Co-Investigator(Kenkyū-buntansha) ITOH Masamitsu  University of Tokyo, Faculty of Medicine, Research Associate, 医学部・医学科, 助手 (80176362)
Project Period (FY) 1989 – 1990
KeywordsTumor Radioresponse / Reoxygenation / Blood Flow / PO_2 / ^<31>P-MRS / Predictive Assay / Mouse Tumors
Research Abstract

Radiation energy directly reaches tissue cells within irradiated area, while drug delivery depends on blood circulation.
Even the same dose is absorbed, however, the response of the tissues depends on their intrinsic radiosensitivity and physiological factors such as oxygen tension. Oxygen tension, in turn, depends on the oxygen supply through blood flow and the oxygen consumption reflecting the metabolic activity of the tissue.
In radiation therapy of tumors what is essential is to kill tumor cells effectively without severe damage on normal tissues involved. The differential outcome of irradiation could be attained by fractionated irradiation utilizing biological/physiological difference between tumor tissues and normal ones.
The aim of the present project has been 1) to analyze oxygen tension, energy level, and blood flow in normal and tumor tissues, 2) to clarify the differential changes in these parameters between the two kinds of tissues after irradiation, and, through the results obtained above, 3) to establish a predictive assay system which would be applicable to human subjects.
The materials in the project were mouse fibrosarcoma NFSA2ALM1 and squamous cell carcinoma NRS1 transplanted in the legs of C3H/He mice.
Oxygen tension, energy level (revealed by ^<31>P-MRS), blood flow in normal and tumor tissues, and growth of tumors have been analyzed and basic data were collected. Furthermore, some information on changes in oxygen tension and energy level after irradiation was also obtained. The analysis of the process of "reoxygenation" after irradiation and the comparison of the results to the previous information based on clonogenic assay has been initiated. Further investigation should, however, be needed to obtain a final conclusion.

  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Suzuki,N.: "Predictive Characteristics of NMR Spectroscopy for Thermoーradio Responses of Murine Tumors." In:Hyperthermic Oncology 1988 Eds.Sugahara T.and Saito M.Taylor and Francis.2. 294-295 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Itoh,M.: " ^<31>P MRS Spectroscopy of NRーSI Tumors after Hyperthermic Treatment." In:Hyperthermic Oncology 1988 Eds.Sugahara T.and Saito M.Taylor and Francis.1. 139-140 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Itoh,M.: "NMR Spectroscopy of Neoplasm." Jpn.J.Cancer Chemother.16. 1167-1172 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Itoh,M.: "Responses of Bone' and Soft Tissue Sarcomas to Preーoperative Chemotherapy Monitored by Pー31 NMR Spectroscopy." Jpn.J.Nuclear Medicine.in press.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki,N.: " ^<31>P NMR Spectroscopy of Murine Tumors for Hyperthermia Treatment." In:Hyperthermic Oncology 1989 Ed.Saito M.(Proceeding of the 6th Annual Meeting). 74-79 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Itoh,M.: "Change of Energy Status on Murine NRーSI Tumor Using in Vivo Pー31 NMR Spectroscopy." In:Hyperthermic Oncology 1989 Ed.Saito M.(Proceedings of the 6th Annual Meeting). 314-319 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki,N.: "Determination of Oxygenation Status of Mouse Tissues using a Platinum Needle Type Sensor." in preparation.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki, N., Itoh, M., Mizukoshi, T and Saito, H.: "Predictive characteristics of NMP spectroscopy for thermo-radio-responses of murine tumors." Hyperthermic Oncology 1988. vo1.2.294-295, Eds. Sugahara, T. and Saito, M., Taylor and Francis, (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gerweck. L. E. and Suzuki, N. :"Magnetic resonance spectroscopy--prediction and detection of response to therapy" Hyperthermic Oncology 1988. vol. 1,. 278-281, Eds. Sngahara, T. and Saito, M., Taylor and Francis, (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Itoh. M., Takahashi, D., Suzuki. N., Iio. M. and Saito, H.: "31P-NMR spectroscopy of NR-S1 mouse tumors after hyperthermic treatment" Hyperthermic Oncology 1988. vol. 1. 139-140, Eds. Sugahara, T. and Saito, M., Taylor and Francis, (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Majima, H. and Suzuki, N.: "Effects of post treatment hypoxia on thermal and radiation sensitivity of CHO and HMV-I cell lines in vitro" Hyperthermic Oncology 1988. vol 1,. 263-265, Eds. Sugahara, T. and Saito, M. Taylor and Francis, (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeda, M., Majima, H., Suzuki, N. and Okada, S. :"Relationship between tumor control and cell survival following X-ray, heat and thermo-X-ray therapy in HMV-I spheroids." Hyperthermic Oncology 1988. vol 1,. 38-40, Eds. Sugahara, T. and Saito, M. Taylor and Francis, (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, N., Itoh, M., Saito, H. and Mizukoshi, T.: "31P NMR spectroscopy of murine tumors for hyperthermia treatment" Hyperthermic Oncology in Japan '89 (Proceedings of the 6th Annual Meeting. Japanese Society of Hyperthermic Oncology). 74-75, Ed. Saito, M., (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Itoh, M., Majima, H. and Suzuki, N. :"Change of energy status on murine NR-S1 tumor using in vivo P-31 NMR spectroscopy" Hyperthermic Oncology in Japan '89 (Proceedings of the 6th Annual Meeting, Japanese Society of Hyperthermic Oncology). 314-315, Ed. Saito, M., (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Itoh, M., Yoshikawa, K., Higaki, S., Yagi, K., Kojima, T., Suzuki, N. and Iio, M. :"Bone and soft tissue sarcomas respones to intensive chemotherapy by 31-P MR spectroscopy." Jpn. J. Nuclear Medicine.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, N., Mizukoshi, T., Majima, H. and Murakami, H: "Determination of oxygenation status of mouse tissues using a platinum needle type sensor"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, N. and Mizukoshi, T. :"Oxygenation status of mouse tumors and effect of local irradiation determined by a platinum needle sensor"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, N. and Kuperman, S.: "A new metastasis system derived from a mouse fibrosarcoma (NFSa) of spontaneous origin and its "clonogenic" tumor-cell-release rate"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, N. and Majima, H.: "Metastatic potential of transplantable SqIISlml carcinoma of WHT/Ht mouse."

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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