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1990 Fiscal Year Final Research Report Summary

Establishment of Pig Family of Congenital Diaphragmatic Hernia, and Studies on its Embryological Basis.

Research Project

Project/Area Number 01480304
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionInstitute of Clinical Medicine, Tsukuda University

Principal Investigator

OHKAWA Haruo  Univ. of Tsukuba, Inst. Clin. Med. Sci., Prof., 臨床医学系, 教授 (30009667)

Co-Investigator(Kenkyū-buntansha) YAGAMI Ken-ichi  Univ. of Tsukuba, Inst. Basic Med. Sci., Associate Prof., 基礎医学系, 助教授 (40166476)
OCHI Gohei  Univ. of Tsukuba, Inst Clin. Med. Sci., Assist. Prof., 臨床医学系, 講師 (20185614)
Project Period (FY) 1989 – 1990
KeywordsPig model / Congenital diaphragmatic hernia / Anorectal malformations / Autosomal gene / Double recessive gene
Research Abstract

Neonatal diaphragmatic hernia is one of the most improtant emergency diseases, with great difficulty of treatment and poor prognosis even in the present stage of pediatric Surgery. This study was performed with a final goal of improvement of the clinical results. Substantially this consists of a part of our research of a pig model with anorectal malformations, which has been established in our Unit.
The main purpose of this study is to establish a pig family of congenital diaphragmatic hernia, from our pig Family with anorectal malformations. So the proper maintenance of our pig Family with anorectal malformations itself will be proven to be a great fruit of the present study.
Unfortunately we did not obtain any new abnormal piglets after the first 13 pigs with congenital diaphragmatic hernia, and the operatively rescued female pig did not give any birth of anomalous piglets in the three normal deliveries. We have not succeeded in the production of Pig Family of congenital diaphragmatic hernia so far.
Detailed anatomical and pathological studies on the 13 anomalous pigs with late onset were performed and were reported precisely in the J. Jpn. Soc. Pediatr. Surg. 1990. The heredity in the pig Family was analyzed by the statistical calculation and the autosomal double recessive genes were proven to exist. This results will be presented in the International Meeting of Pediatric Surgery this year, and will be pressed in the J. Pediatr. Surg.
As without any fetus material with diaphragmatic hernia in this experiment up to the present, we have not been successful in the embryological analysis with anomalous materials so far.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 大川 昭央: "新性児外科の治療成績" 日本外科学会雑誌. 9(9). 1314-1316 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松本 正智: "ブタ家族性横隔膜ヘルニアの病理学的遺伝学的検討" 日本小児外科孝雑誌. 26. 1118-1124 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大川 治夫: "直腸肚門奇形〜ブタモデル" 小児外科. 22(6). 499-505 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大川 治夫: "ブタ鎖肚モデルさ用いた研究" 外科. 53(1). 93-97 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大川 治夫: "肺の低形成自体が先天性横隔膜ヘルニアの発性原因か" Mebio. 7(2). 9 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Ohkawa: "Familialcongenitaldiaphragmaficherniaofp:g;PathologyandGenetics" J.Pediatr.Surg. (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大川 治夫: "産婦人科治療の実際" 永井書店, 5 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M. Matsumoto, H. Ohkawa, G. Ochi, T. Hori, K. Ueoka and S. Sawaguchi ;: "Pathological and genetical studies on familial congenital diaphragamatic hernia in pig." J. Jpn. Soc. Pediatric Surgeons. 26(6). 1118 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Ohkawa, M. Kaneko, M. Sakaniwa, G. Ochi, T. Hori, M. Matsumoto ;: "Treatment results of neonatal surgical cases." J. Jpn. Surgical Society. 9(9). 1314 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Ohkawa and M. Matsumoto ;: "Research on the pig model of anorectal malformations" Surgery (Tokyo). 53(1). 93 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Ohkawa, M. Matsumoto, K. Ikebukuro and G. Ochi: "Establishment of a pig animal model for anorectal malformations and its application to embryological studies." Jpn. J. Pediatr. Surg.22(6). 499 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Ohkawa ;: "Is the dysplastic lung itself the embryological csuse for genesis of diaphragamtic hernia." Mebio. 7(2). 9 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Sawaguchi and H. Ohkawa ;: "Review on the new aspect of Clinical Medicine : Pediatric Surgery." Japan Medical Journal. 3435. 43 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Ohkawa, M. Matsumoto ;: "Familial congenial diaphragmatic hernia of pig ; Pathology and genetics." J. Pediatr. Surg.(1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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