1991 Fiscal Year Final Research Report Summary
Studies on the Inhibitory Effect of Blood Transfusion Against Anti-Tumor Immunity
| Project/Area Number |
01480312
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
KODAMA Masashi Shiga University of Medical Science, Professor, 医学部, 教授 (50079836)
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| Co-Investigator(Kenkyū-buntansha) |
SANO Haruo Shiga Univirsity of Medical Science, Medical Staff, 医学部, 医員
TERADA Nobukuni Shiga Univirsity of Medical Science, Lecturer, 医学部, 講師 (50167756)
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| Project Period (FY) |
1989 – 1991
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| Keywords | Blood transfusion / Immunological suppression / CTL / NK / TNP-CTL / Suppressor cell |
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| Research Abstract |
To analyze the mechanism on the effect of blood transfusion, we studied on survival rate in mice in vivo experiments. Mice that received allogenic blood had significantly worse survival rate than either syngenic-transfuued or saline-infused control groups (C57BL/10 : p<0.05, BALB/C : p<0.01). A transfusion of lymphocytes reduced survival rate in comparison with a transfusion of plasma or RBC (P<0.05). On the other hand, in vitro experiments, the responses of the greop transfused with allogenic donors were significantly lower than responses of control or syngenic transfused group, in either anti-X5563 CTL (P<0.05), TNP-CTL (p<0.01), or NK (p<0.05). Furthermore, we demonstrated that the suppression of CTL activity was mediated by suppressor cells.
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