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1991 Fiscal Year Final Research Report Summary

Creation and analysis of the animal models with chronic compression myelopathy.

Research Project

Project/Area Number 01480366
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionNagoya University

Principal Investigator

MIMATSU Kentaro  Nagoya University School of Medicine, Lecturer, 医学部, 講師 (10126906)

Co-Investigator(Kenkyū-buntansha) SATO Kouji  Nagoya University School of Medicine, M. D., 医学部, 医員
KISHI Seiichi  Nagoya University School of Medicine, M. D., 医学部, 医員
SAITO Haruhiko  Nagoya University School of Medicine, M. D., 医学部, 医員
HASHIZUME Yoshio  Nagoya University School of Medicine, Associate profesor, 医学部, 助教授 (70106227)
Project Period (FY) 1989 – 1990
Keywordsspinal cord / chronic myelopathy / animal / SEP
Research Abstract

To determine the functional changes occurring in the early period after the development of chronic cord compression, we created an ossification of the yellow ligament(OYL)model, which is a model of chronic cord compression, in domestic rabbits using bone morphogenetic protein(BHP), and monitored evoked spinal cord potentials(ESCP). Sixty-seven rabbits were used for these experiments. Myelography, ESCP measurements, and histological examinations were performed in 16 of the OYL and 6 of the healthy control rabbits.
At an average of 40.6 weeks after creitio, of the OYL model, a mean cord compression ratio of 15.3% was found. When the sciatic nerve was stimulated, no significant differences were found in the latency of the ESCP first wave between the OYL and control rabbits, whereas with stimulation delivered to the motor area the first wave latency differed significantly(P<0.005)between the 2 groups when the cord compression ratio in the OYL rabbits was *10%. Histological changes consisting primarily of a reduction in the number of large fibers in the dorsal column were found in 3 of the 4 OYL rabbits showing a cord compression ratio of *20%.
Our results demonstrate that(1)mild degrees of cord compression produce greater ESCP alterations in chronic than in acute cord compression, (2)chronic cord compression from the dorsal side produces injury in the superficial layer of the dorsal column and dorso-lateral column, and(3)changes in ESCP precede the development of paralysis and histological changes.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 村上 英喜他: "黄色靭帯骨化モデルー脊財後縦靭帯、黄色靭帯、棘上靭帯とBMPとの反応からー" 臨床整形外科. 23. 397-402 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岸 精一 他: "家兎実験的慢性脊髄圧迫における大脳皮質刺激脊髄誘発電位について" 中部日本整形外科.災害外科学会誌. 32. 1179-1181 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 村上 英喜: "脊椎靭帯とBMPとの反応、ならびに黄色靭帯骨化モデルの作製ー脊椎靭帯骨化症の成因についてー" 日本整形外科学会雑誌. 62. 1211-1220 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Koi Sato et.al.: "Changes in the evoked spinal cord potentials associated with chronic experimental cord compression." Spine. 16. 1283-1289 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hideki Murakami et. al.: "A model of the ossification of the yellow ligament. -Tissue culture of spinal ligaments with bone morphogenetic protein and experimental intra-ligamentous ossification using bone morphogenetic protein-" Rinsyo Seikeigeka. 23. 397-402 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Seiichi Kishi et. al.: "Cortically evoked spinal potentials on experimental choronic spinal cord compression in rabbits." Cent. Jpn. J. Orthop. Traumat.32. 1179-1181 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hideki Murakami: "Experimental study on ossification of spinal ligaments in the rabbit under influence of bone morphogenetic protein." J. Jpn. Orthop. Assoc.62. 1211-1220 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koji Sato et. al.: "Changes in the evoked spinal cord potentials associated with choronic experimental cord compression." Spine. 16. 1283-1289 (1988)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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