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1990 Fiscal Year Final Research Report Summary

Teh Effect of Combined Therapy with Hyperbaric Oxygenation and Calcium Antagonists on Postischemic Delayed Neurocellular Death

Research Project

Project/Area Number 01480374
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionTohoku University

Principal Investigator

IWATSUKI Naofumi  Tohoku Univ. School of Medicine, Associate Prof., 医学部, 助教授 (50004908)

Co-Investigator(Kenkyū-buntansha) YASUDA Akio  Tohoku Univ. School of Medicine, Associate, 医学部, 助手 (00166505)
SAISHU Toshio  Tohoku Univ. University Hospital, Associate, 医学部附属病院, 助手 (30201502)
Project Period (FY) 1989 – 1990
KeywordsComplete global cerebral ischemia / Postischemic brain damage / Delayed neurocellular death / Calcium antagonist / Thromboxine A_2 antagonist / Adenosyl methionine / Hyperbaric oxygen therapy
Research Abstract

Effects of several treatment for postischemic brain damage (PIBD) were evaluated on the canine model of 15 min complete cerebral ischemia which we established.
1. Effects of drugs given after ischemia :
Calcium antagonists (flunarizine, diltiazem, nicardipine) administered for 3 days effectively accelerated the recovery from PIBD expressed by neurologic recovery score (NRS) (58.7 vs 40.3 in the control at 7th day.) There were, however, no significant differences in the efficacy between the three dr
uugs.
A thromboxine A_2 antagonist was effective only to the recovery of electrophysiological function (EEG and evoked potential), but not to that of NRS. S-adenosy 1-L-methionine had no beneficial effect for the treatment of PIBD.
2. Effects of hyperbaric oxygen therapy (HBOT) :
Hbot under 3 ATP with 100 % oxygen for 1 hour was performed at 2, 24 and 30 hours after ischemia. NRS was significantly higher in Hbot group (68.6). The almost complete recovery (over 65 in NRS) was obtained in 6/9 of Hbot (two of which were complete recovery = over 90), while in 1/10 of the control. The obvious efficacy of Hbot for the treatment of Pibd was suggested.
The combined therapy with HBOT and nicardipine was completed on 3 dogs until now. NRS at 14 days after ischemia were 89.4, 74.3 and 100, respectively, suggesting the better recovery with the combined therapy.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 岩月 尚文: "虚血後脳障害に対するカルシウム拮抗薬の治療効果" 医学のあゆみ. 150. 261-261 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masahiko TAKAHASHI: "The Effects of a Thromboxane A_2 Receptor Antagonist on Neurologic Recovery after 15min Complete Global Brain Ischemia in Dogs." J.Anesth. 5. 73-78 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Katsuhiko ONO: "The Effects of Calcium Antagonists on EEG,Evoked Potential and Neurologic Recovery after Complete Global Brain Ischemia for 15 minutes in Dogs." J.Anesth.5. (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masahiko TAKAHASHI: "Hyperbaric Oxygenation Accelerated Neurologic Recovery after 15 min Complere Global Brain Ischemia in Dogs." Crit.Care Med.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Naofumi IWATSUKI: "Therapitic Effects of Calcium Antagonists on Postischemic Brain Damage" J. Clin. Ext. Med. 150. 261-261 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masahiko TAKHASHI: "The Effects of a Thromboxane A_2 Receptor Antagonist on Neurologic Recovery after 15 min Complete Global Brain Ischemia Dogs" J. Anesth.5. 73-78 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Katsuhiko ONO: "The effects of Calcium Antagonists on EEG, Eveked Potential and Neurologic Rcovery after Complete Global Brain Ischemia for 15 minutes in Dogs" J. Anesth.5. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masahiko TAKAHASHI: "Hyperbaric Oxygenation Accelerated Neurologic Recovery after 15 min Complete Global Brain Ischemia in Dogs" Crit. Care Med.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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