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1991 Fiscal Year Final Research Report Summary

A study on the development of fetal behavior and central nervous system

Research Project

Project/Area Number 01480389
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Tokyo

Principal Investigator

KUWABARA Yoshinori  Univ.of Tokyo, Facul.of Med. (Hosp.), Associate Professor, 医学部(病), 助教授 (20010324)

Co-Investigator(Kenkyū-buntansha) UNNO Nobuya  Univ.of Tokyo, Facul.of Med. (Hosp.), Registrar, 医学部(病), 助手 (90193979)
KOZUMA Shiro  Univ.of Tokyo, Facul.of Med. (Hosp.), Registrar, 医学部(病), 助手 (30143457)
OKAI Takasi  Univ.of Tokyo, Facul.of Med. (Hosp.), Assistant Professor, 医学部(病), 講師 (40126016)
Project Period (FY) 1989 – 1991
Keywordsartificial placent / ECMO / fetal goat / fetal behavior / eye movements / central vervous system
Research Abstract

We developed a system of extrauterine incubation of a goat fetus, in which the fetus in surrounded by artificial amniotic fluid and connected to the circuit with an ECMO (extracorporeal membrane oxygenator) by the umbilical arteries and veins.
The mean duration of the incubation was 83 hours and 48 minutes with a recent improvement. Tne longest one was 143 h.and 48 min.in this series. Slowly progress of circulatory depression and systemic body edema were thought to be the main cause of fetal death.
EEG,EOG,intratracheal presuure, EMG of nucal and thigh muscle were monitored continuously. Four categories of behavioral states were defined on the basis of the findings of these monitoring and the fetal movements observed with naked eyes.
The effects of PGE_2, and PGD_2, which are known as regulators of sleep-wakefulness cycle, on behavioral states defined above were investigated to clarify the meanings of these behavioral states. As a result of these experiments, it was suggested that four categories of behavioral states in extra-uterine fetal goats were deep Non-REM sleep, shallow Non-REM sleep, REM sleep and wakefulness.
The detail is shown in the text of the report.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 海野信也、桑原慶紀他: "人工子宮の開発:A-V ECMOによる子宮外胎仔保育における最適臍帯血流量に関する検討" 今日の人工臓器. 2(3). 197-204 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 海野信也、桑原慶紀他: "臍帯を用いたA-V ECMOによる子宮外胎仔保育" 人工臓器. 14(Suppl 3). 268-269 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 海野信也、桑原慶紀他: "人工子宮の開発:A-V ECMOによる子宮外胎仔保育における酸素消費に関する検討" 胎児診断と治療. 5(3-4). 189-195 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Unno, Y.Kuwabara, et al.: "Development of an Artificial Placenta : Optimal Extracorporeal Flow Blood Flow in Goat Fetuses during Extrauterine Incubation with Umbilical Arterio-venous Extracorporeal Membrane Oxygenation." Artificial Organs Today. 2 (3). 197-204 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Unno, Y.Kuwabara, et al.: "THE EXTRAUTERINE INCUBATION OF GOAT FETUSES USING UMBLICAI,ARTERIO-VENOUS ECMO." Artificial Organs. 14 (Suppl 3). 268-269 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Unno, Y.Kuwabara, et al.: "Development of artificial Placenta : Oxygen metabolism of isolated goat fetuses with umbilical arterio-venous estracorporeal membrane oxygenation." Fetal Diagnosis and Therapy. 5 (3-4). 189-195 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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