1991 Fiscal Year Final Research Report Summary
Establishment of an animal model for the study of tumor-dormancy.
| Project/Area Number |
01480510
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Niigata University |
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Principal Investigator |
SATO Norimitsu Niigata Univ. Sch. Med. Assoc. Prot., 医学部, 助教授 (00111716)
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| Co-Investigator(Kenkyū-buntansha) |
FUJISAWA Nobuyoshi Niigata Univ. Sch. Med. Assist., 医学部, 助手 (50199311)
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| Project Period (FY) |
1989 – 1991
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| Keywords | tumor-dormancy / animal model / ddY mouse / mouse substrain / Ehrlich ascites tumor / solid tumor / tumor progression / research model for cancer therapy |
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| Research Abstract |
1. Using ddY mice and Ehrlich ascites tumor cells (E cell), an animal model for the study of tumor-dormancy has been established by selective breeding. In the dormant mice (drm-mice), Ehrlich ascites tumor cells are dormant for about 100 ds in the dermal tissue but progressive in the peritoneal cavity.
2. Dormant effect of drm-mice can be transferred by E cell-activated spleen cells to the progressive I : Ine of mice (prg-mice).
3. From the lymphocyte surface antigens test, H-2 haplotype of drm-mice (F-15) and prg-mice (F-10) were determined as s and q respectively. Mixed lymphocytes are activated reciprocally between the two sublines, and the skin grafts are also rejected.
4. In another inbred strains of mice, E cell in the dermal tissue was progressive in mice of H-2 haplotype k, q and v, ; dormant in d and r, ; regressive or dormant in p and s, ; regressive in b. In their peritoneal cavity, however, E cell was all progressive.
5. From the above results, the present animal model involves cellular immune response in the tumor-dormancy mechanism and makes E cell dormant for long periods -in the dermal tissue. In the mechanism, histo-compatibility genes other than H-2 loci-seems to be important for the dermal-lymphocytes recognition system against E cell.
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