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1990 Fiscal Year Final Research Report Summary

Molecular Design of Specialty Polymers Carrying Oligosaccharide Chains as Cell Recognition Signals

Research Project

Project/Area Number 01550715
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 高分子合成
Research InstitutionNagoya University

Principal Investigator

KOBAYASHI Kazukiyo  Nagoya University, Faculty of Agriculture, Associate Professor, 農学部, 助教授 (10023483)

Co-Investigator(Kenkyū-buntansha) OKADA Masahiko  Nagoya University, Faculty of Agriculture, Professor, 農学部, 教授 (20023103)
Project Period (FY) 1989 – 1990
KeywordsBiomedical Meterials / Glyco Engineering / Molecular Recognition / Ringーopening Polymerization / Synthetic Polysaccharides / Oligosaccharide / Carbohydrate-Carrying Polymers / Cell-Specific Materials
Research Abstract

We have given attention to oligosaccharide chains as the key parti,cipants in cell-cell recognitions of various biological events. Well-defined polymers having oligossaccharide chains should serve as cellーspecific biomedical materials. Following six types of polymers having galactose, mannose, N-aceylglucosamine, and glucose residues as recognition markers have been synthesized.
(1) Oligomers of lactose-substituted styrene monomer. Via radical telomerization.
(2) Homopolymer of N-acetylchito-oligosaccharide substituted styrene. Via redical polymerizaton of macromonomer.
(3) Star-type graft copolymers. Via radical polymerization of macromer from sugar-carrying methyl=methacrylate monomer.
(4) Comb-shaped branched polysaccharides, 4-O-(alpha-D-mannopyranosyl)-(1->6)-alpha-D-mannopyranan. Via ring-opening polymerization of anhydro disaccharide derivatives.
(5) (1->6)-beta-D-Galactopyranan. Via steric control by neighboring-group participation in ring-opening polymerization.
(6) Oligosaccharide-carrying polypeptides. Via polymeric reaction of poly (L-glutamic acid).

  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 赤池 敏宏: "オリゴ糖置換ポリスチレンへの肝細胞の接着" 日本農芸化学会誌. 64. 145-150 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林 一清: "新しい血小板粘着阻止材料の分子設計" 化学工業. 41. 312-315 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林 一清: "糖質工学と生体機能材料" 化学と生物. 28. 258-266 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林 一清: "糖質高分子を基質材料に用いる肝細胞接着と糖鎖高密度効果の発現" Trends in Glycoscience&Clycotechnology. 2. 26-32 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Hirai: "CP/MAS 13C NMR Study of Linear Dextran Crystallized from Poly(ethylene Glycol)ーWater Solution at a High Temperature" Macromolecules. 23. 1837-1841 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Ichikawa: "Synthesis of a Combーshaped Branched Polysaccharide via RingーOpening Polymerization of a Reactive Anhydro Disaccharide Derivative" Macromolecules. 23. 1884-1886 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kobayashi: "StructureーControlled Synthesis of Specialty Polysaccharides" Preceedings of the ACS division. 62. 477-481 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高山 崇: "糖側鎖を有するポリスチレン誘導体の抗血小板粘着作用" 生体材料. 8. 122-128 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kobayashi: "Regioselectively Modified Stereoregular Polysaccharides.I. Synthesis and Functions of (1→6)ーαーDーGlucopyranans Having One Long Hydrocarbon Chains in Position 3 in Each Repeating Unit" Macromolecules. 23. 3808-3710 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kobayashi: "Synthesis of an NーAcetylchito OligosaccharideーCarrying StyreneーType Macromer and Its Homopolymer" Makromol.Chem.,Rapid Commun.11. (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林 一清: "ラクト-ス誘導体を側鎖にもつポリペプチド" 高分子論文集(生体機能材料特集号). (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林 一清: "長鎖アルキル基をもつ多糖の合成と機能" 油化学(「糖脂質」小特集). (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kobayashi: "Polymer Year Book" Gordon and Breach Science Publishers,Inc., 6 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kobayashi: "Polymer Year Book" Gordon and Breach Science Publishers,Inc., (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kobayashi: "Polymer Year Book" Gordon and Breach Science Publishers,Inc., (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kobayashi: "Polymers from Biotechnology" Plenum,

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林 一清: "「接着剤の分子設計」" 日本接着学会,

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A. Hirai: "CP/MAS 13C NMR Study of Linear Dextran Crystallized from Poly(ethylene Glycol)-water Solution at a High Temperature" Macromolecules. 23. 1837-1841 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Ichikawa: "Synthesis of a Comb-shaped Branched Polysaccharide via Ring-Opening Polymerization of a Reactive Anhydro Disaccharide Derivative" Macromolecules. 23. 1884-1886 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Kobayashi: "Structure-Controlled Synthesis of Specialty Polysaccharides" Preceedings of the ACS division. 62. 477-481 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Kobayashi: "Regioselectively Modified Stereoregular Polysaccharides. II. Synthesis and Functions of (1->)-alpha-D-Glucopyranans Having One Long Hydrocarbon Chain in Position 3 in Each Repeating Unit" Macromolecules. 23. 3808-3810 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Kobayashi: "Synthesis of an N-Acetylchito Oligosaccharide Carrying Styrene-Type Macromer and Its Homopolymer" Makromol. Chem., Rapid Commun.11. (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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