1990 Fiscal Year Final Research Report Summary
Molecular Design of Specialty Polymers Carrying Oligosaccharide Chains as Cell Recognition Signals
| Project/Area Number |
01550715
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
高分子合成
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| Research Institution | Nagoya University |
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Principal Investigator |
KOBAYASHI Kazukiyo Nagoya University, Faculty of Agriculture, Associate Professor, 農学部, 助教授 (10023483)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Masahiko Nagoya University, Faculty of Agriculture, Professor, 農学部, 教授 (20023103)
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| Project Period (FY) |
1989 – 1990
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| Keywords | Biomedical Meterials / Glyco Engineering / Molecular Recognition / Ringーopening Polymerization / Synthetic Polysaccharides / Oligosaccharide / Carbohydrate-Carrying Polymers / Cell-Specific Materials |
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| Research Abstract |
We have given attention to oligosaccharide chains as the key parti,cipants in cell-cell recognitions of various biological events. Well-defined polymers having oligossaccharide chains should serve as cellーspecific biomedical materials. Following six types of polymers having galactose, mannose, N-aceylglucosamine, and glucose residues as recognition markers have been synthesized.
(1) Oligomers of lactose-substituted styrene monomer. Via radical telomerization.
(2) Homopolymer of N-acetylchito-oligosaccharide substituted styrene. Via redical polymerizaton of macromonomer.
(3) Star-type graft copolymers. Via radical polymerization of macromer from sugar-carrying methyl=methacrylate monomer.
(4) Comb-shaped branched polysaccharides, 4-O-(alpha-D-mannopyranosyl)-(1->6)-alpha-D-mannopyranan. Via ring-opening polymerization of anhydro disaccharide derivatives.
(5) (1->6)-beta-D-Galactopyranan. Via steric control by neighboring-group participation in ring-opening polymerization.
(6) Oligosaccharide-carrying polypeptides. Via polymeric reaction of poly (L-glutamic acid).
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