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1990 Fiscal Year Final Research Report Summary

Study on Regulatory Mechanism of Liver Regeneration

Research Project

Project/Area Number 01570400
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionYamaguchi University School of Medicine Grant-in-Aid for Scientific Research (C)

Principal Investigator

OKITA Kiwamu  Yamaguchi University School of Medicine, Prof., 医学部, 教授 (70107738)

Co-Investigator(Kenkyū-buntansha) YASUNAGA Mitsuru  Yamaguchi Univ. School of Med., Assis. Prof, 医学部附属病院, 助手 (90230234)
KONISHI Tomomi  Yamaguchi Univ. School of Med., Assist. Prof, 医学部附属病院, 助手 (30195755)
FUKUMOTO Yohei  Yamaguchi Univ. School of Med., Assoc. Prof., 医学部, 助教授 (90136193)
Project Period (FY) 1989 – 1990
KeywordsLiver Regeneration / Fulminant hepatitis / Epidermal Growth Factor (EGF) / EGF receptor / Acute-on-Chronic / Impaired Liver Regeneration
Research Abstract

It is well-known that fulminant hepatitis is based upon severe hepatic cell necrosis. In this sense, this applicant has got the idea that promotion of liver regeneration might improve the mortality in this pathologic condition.
For these two years, we have mainly studied on how much Epidermal Growth Factor (EGF) can cause liver regeneration in this disease. First of all, we administered EGF into the rats carrying acute liver failure developed with CCl_4. Surprisingly, remarkable DNA synthesis could be induced in the liver after administration of EGF. Number of DNA synthesizing hepatocytes reached at maximum in case of its intra-portal administration, as compared with intra-peritoneal and intra-venous routes. On the other hand, we also investigated that EGF could stimulate DNA synthesis in the liver carrying acute liver failure on chronic liver injury (AOC) which has been known to be higher mortality than fulminant hepatitis. We developed animal model for AOC by means of administration of d-galactosamine into the animals with chronic liver injury induced with chronic treatment with CCl_4.
In conclusion, exogenously administered EGF never caused the increase of DNA synthesizing hepatocytes in this condition. Therefore, we can understand AOC is a condition of impaired liver regeneration.

  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Oka H.,Fujiwara K.,Okita K.,et al: "A multiーcentre doubleーblind controlled trial of glucagon and insulin therapy for severe hepatitis." GASTROENTEROLOGIA JAPONICA. 24(3). 332-336 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐々木 功典,村上 知之,沖田 極,ほか: "ヒト肝細胞癌HuHー7の増殖ならびにαーフェトプロティン産生に及ぼすグリチルリチンの影響" BIOTHERAPY. 3(6). 1515-1518 (1989)

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      「研究成果報告書概要(和文)」より
  • [Publications] 山下 智省,安永 満,沖田 極,ほか: "各種肝疾患における血中Thromibinーantithrombin III複合体の測定の意義" 肝胆膵. 19(4). 841-846 (1989)

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      「研究成果報告書概要(和文)」より
  • [Publications] 沖田 極,渡辺 明治,赤松 興一: "劇症肝患の救命率の向上のために" THEAPEUTIC RESEARCH. 10(3). 751-765 (1989)

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      「研究成果報告書概要(和文)」より
  • [Publications] 安永 満,沖田 極: "急性肝不全の特殊療法の評価" 治療学. 24(3). 305-308 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] 山下 智省,沖田 極: "劇症肝炎" 臨床と研究. 67(4). 1039-1043 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] Okita K.,Mizumachi S.,Takemoto T.: "Role of epidermal growth factor in protection,repair and healing of gastroduodenal mucosal injury" DRUG INVESTIGATION. 2(Supple). 13-17 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] 沖田 極,黒川 典枝 山崎 隆浩: "小柴胡湯による肝発癌予防の可能性" 消化器科. 12(2). 152-156 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] 沖田 極,安永 満: "肝再生調節ペプチドとしてのインスリン・グルカゴン" 肝胆膵. 21(1). 25-29 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] 村上 不二夫: "急性肝障害におけるEpidermal Growth Factorによる肝再生促進効果についての検討" 肝臓. 31(8). 921-927 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] 白澤 宏幸: "ラットAcuteーonーChronicモデルにおける肝再生とEGH receptorの比較" 肝臓. 31(10). 1152-1158 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] 李 千,沖田 極: "小柴胡湯に含まれる薬効成分バイカレンの培養ヒト肝癌細胞(HuHー7)に対する増殖抑制効果" BIOTHERAPY. 4. 1664-1670 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] 沖田 極,安永 満: "劇症肝炎" 臨床成人病. 20(5). 1010-1013 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] 沖田 極,田中 祐子,李 千: "肝再生の基礎と臨床癌増殖との関連" 肝胆膵. 21(6). 1095-1100 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] Okita K.,Karita M.,Nakanishi N.,et al: "Role of epidermal growth factor in Protection and repair of gastric muscosal injury" J CLINICAL GASTROENTEROLOGY. (1991)

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      「研究成果報告書概要(和文)」より
  • [Publications] 沖田 極: "「劇症肝炎」(Common Disease Series 9ー肝炎)" 南江堂(鈴木宏編), 4 (1989)

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      「研究成果報告書概要(和文)」より
  • [Publications] 沖田 極: "「亜急性肝炎」(内科学)" 朝倉出版, (1991)

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      「研究成果報告書概要(和文)」より
  • [Publications] 沖田 極: "「肝不全の臨床ー急性肝不全」(最新内科学大系)" 中山書店, (1991)

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      「研究成果報告書概要(和文)」より
  • [Publications] 沖田 極: "「劇症肝炎を早期に診断するコツー劇症化の予知」(モダン・クリニカルポイント内科)" 金原出版, (1991)

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      「研究成果報告書概要(和文)」より
  • [Publications] 沖田 極,安永 満: "「EGFと肝再生」(第4回 肝の生化学ー箱根シンポジウム記録)" 中外出版, (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oka H., Fujiwara K., Okita K., et al: "A multi-center double-blind controlled trial of glucagon and insulin therapy for severe hepatitis" Gastroenterologia Japonica. 24(3). 332-336 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki K., Murakami T., Okita K., et al: "Influence of glycyrrhizine on proliferation and alpha-fetoprotein production in HuH-7 hepatoma cells" Biotherapy. 3(6). 1515-1518 (1989)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Yamashita S., Yasunaga M., Okita K.: "Significance of thrombin-antithrombin complex in miscellaneous liver diseases." Kan-Tan-Sui. 19(4). 841-846 (1989)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Okita K., Watanabe A., Akamatsu K.: "For improvement of mortality in fulminant hepatitis." Therapeutic Research. 10(3). 751-765 (1989)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Yasunaga M., Okita K.: "Evaluation of specific therapies for acute liver failure." Chiryougaku. 24(3). 305-308 (1990)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Yamashita S., Okita K.: "Fulminant Hepatitis." Rinsho-to-Kenkyu. 67(4). 1039-1043 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okita K., Mizumachi S., Takemoto T.: "Role of epidermal growth factor in protection, repair and healing of gastroduodenal mucosal injury" Drug Investigation. 2(suppl). 13-17 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okita K., Kurokawa F., Yamasaki T.: "Possible chemoprevention of chemical hepatocarcinogenesis with Shosaiko-to." Shokakika. 12(2). 152-156 (1990)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Okita K., Yasunaga M.: "Insulin and glucagon to be regulatory peptides for liver regeneration." Kan-Tan-Sui. 21(1). 25-29 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murakami F.: "Biochemical analysis of accelerated liver regeneration with epidermal growth factor in rat with acute liver injury." Kanzo. 31(8). 921-927 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shirasawa H.: "Impaired liver regeneration and EGF receptor in experimentally induced "acuteon-chronic" type liver failure." Kanzo. 31(10). 1152-1158 (1990)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Li Qain, Okita K., Murakami T., et al: "Inhibitory effect of baicalein on the growth of cultured hetoma cells (HuH-7)." Biotherapy. 4(10). 1664-1670 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okita K., Yasunaga M.: "Fulminant hepatitis." J Adult Diseases. 20(5). 1010-1013 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okita K., Tanaka H., Li Quain: "Liver regeneration - in association with tumor growth" Kan-Tan-Sui. 21(6). 1095-1100 (1990)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Okita K., Karita M., Nakanishi N., et al: "Role of epidermal growth factor in protection and repair of gastric mucosal injury" J Clinical Gastroenterology.

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      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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