1990 Fiscal Year Final Research Report Summary
New Regulatory Mechanism of Liver Gluconeogenesis and its Abnormality.
| Project/Area Number |
01570639
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
内分泌・代謝学
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| Research Institution | Osaka University |
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Principal Investigator |
KUWAJIMA Masamichi Osaka University Medical School, Department of Internal Medicine, Assistant Professor, 医学部, 助手 (00205262)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Takao Osaka University Medical School, Department of Internal Medicine, Assistant Prof, 医学部, 助手 (40206199)
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| Project Period (FY) |
1989 – 1990
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| Keywords | Gluconeogenesis / Etomoxir / Fructose 2, 6-Bisphosphate / carnitine / fatty acid oxidation / carnitine palmitoyltransferase |
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| Research Abstract |
Because gluconeogenesis plays a key role on glucose homeostasis, it is important to analyse the regulatory mechanism of gluconeogenesis in liver. Our results were as follows :
1. We analyzed the levels of fructose 2, 6-bisphosphate (F2, 6P_2) in liver of rats after refeeding of carbohydiates. F2, 6P_2 levels depend on 1) ratio of 2 kinase activity to F2, 6P_2 phosphatase activity in liver and 2) ratio of insulin level to glucagon level in serum.
2. Juvenile visceral steatosis (jvs) mouse was associated with systemic carnitine deficiency. Administration of carnitine to jvs could cure hypoglycemia. This results show that the importance of fatty acids metabolism on gluconeogenesis.
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[Publications] I.Mineo,N.Kono,Y.Yamada,N.Hara,H.Kiyokawa,T.Hamaguchi,M.Kawachi,T.Yamasaki,H.Nakajima,M.Kuwajima,S.Tarui: "Glucose infusion afolishes the excessive ATP degradation in working muscles of a patient with Mcardle's disease" Muscle Nerve. 13. 618-620 (1990)
Description
「研究成果報告書概要(和文)」より
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[Publications] M.Kuwajima,N.Kono,M.Horiuchi,Y.Imamura,A.Ono,Y.Inui,S.Kawata,T.Koizumi,J.Hayakawa,I.Siheki,S.Tarui: "Animal model of syotemic carnitine deficiency:Analysis in C3HーHー2ﾟ strain of mouse associated with juvenile visceral steatosis." Biochem.Biophys.Res.Commun.
Description
「研究成果報告書概要(和文)」より
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[Publications] Y.Yamada,N.Kono,H.Nakajima,T.Shimizu,H.Kiyokawa,M.Kawachi,A.Ono,T.Nishimura,M.Kuwajima,S.Tarui: "Low glucoseー1,6・bisphosphate and high fructoseー2,6ーBisphosphate concentrations in muscles of patients with glycogenosis types VII and V." Biochem.Biophys.Res.Commun.
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「研究成果報告書概要(和文)」より
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[Publications] M. Kuwajima, N. Kono, M. Horiuchi, Y. Imamura, A. Ono, Y. Inui, S. Kawata, T. Koizumi, J. Hayakawa, T. Saheki, S. Tarui: "Animal model of systemic carnitine deficiency : Analysis in C3H-H-2^ﾟ strain of mouse associated with juvenile visceral steatolysis." Biochem. Biophys. Res. Commun.
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[Publications] Y. Yamada, N. Kono, H. Nakajima, T. Shimizu, H. Kiyokawa, M. Kawachi A. Ono, T. Nishimura, M. Kuwajima, S, Tarui: "Low glucose-1, 6-bisphosphate and high fructose-2, 6-bisphosphate concentrations in muscles of patients with glycogenosis types VII and V." Biochem. Biophsy. Res. Commun.
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「研究成果報告書概要(欧文)」より
