1990 Fiscal Year Final Research Report Summary
The study of molecular mechanism undergoing the development of thyroid cancer
| Project/Area Number |
01570647
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
内分泌・代謝学
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| Research Institution | Nagasaki University School of medicine |
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Principal Investigator |
IZUMI Motonori Nagasaki University School of Medicine I'Depart. Med associate Prof, 医学部・第一内科, 助教授 (80039552)
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| Co-Investigator(Kenkyū-buntansha) |
NAGATAKI Shigeki Nagasaki University School of Medicine I'Depart. Med. assistant, 医学・第一内科, 助手 (00220062)
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| Project Period (FY) |
1989 – 1990
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| Keywords | thyroid cancer / oncogene / PTC oncogene / retinoci acid / interleukin 1 / TSH receptor / thyroglobulin / thyroid peroxidase |
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| Research Abstract |
Recently a new oncogene PTC has been reported to cause human papillary thyroid carcinoma, therefor we investigated whether this PTC gene exist in thyroid carcinoma using four thyroid cancer cell lines and 22 patients with papillary thyroid carcinoma. PTC gene was detected in only one thyroid carcinoma cell line and was not detect in other three cell lines and the whole 22 patients suggesting that PTC oncogene does not at least in Japan cause thyroid carcinoma.
Thyroid cell line NPA and WRO were investigated to find that ^<125>I TSH could find specfically these cell but TSH could not stimulate CAMP production and that cholexa toxin, forskolin and isoprotenol could stimuilate CAMP productor suggesting some abnormality in Gprotein coupled with TSH receptor. NPA could be stimulated to increase in the uptake of ^3H thymidine by CAMP or forskolin and this increase uptake is inhibited by IL_1 in dore dependent manner, suggesting that IL_1 has antitumorgenecity in some thyroid cancer.
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Research Products
(18 results)
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[Publications] Nomber H,Yaneshitu S,Pei HC,Ishikewa N,Villadolid UC,Tominaga T,Kimue H,Tsuruta N Izumi M,Ishigaki J,Ito K,Nagatahi S: "Lack of PTC gene (ret proto oneogene rearayement)in human thyroid Tumor" Endocinol Japan. 38. 627-632 (1991)
Description
「研究成果報告書概要(和文)」より
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[Publications] Tominaga,T.,Yamashita,S.,Nagayama,Y.,Morita,S Yokoyama,N.,Izumi,M.Nagataki S.: "Interleukin 6 inhibits human thyroidase peroxidase gene expression" Acta Endocrinologca. 124. 290-294 (1991)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Namba, H.,Yamashita,S.,Pei,HC.,Ishikawa.N.,Villadolid,MC.,Tominaga,T.Kimura,H. Tsuruta;M.Yokoyama.N.Izumi,M., Ishigaki,J, Ito,K.Nagataki.S: "Lack of PTC gene (ret proto-oncogene rearrangement) in human thyroid tumors." Endocrinol Japan. 38. 627-632 (1991)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kimura,H.,Yamashita,S.Namba,H.,Usa.T.,Nishikawa,T.,Fujiyama,K.,Tsuruta,M.,Yokoyama N., Izumi,M.Nagataki,S: "Impairment of TSH signal transduction system in human thyroid carcinoma cells." Exp Cell Res.
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kimura,H.,Yamashita,S.,Namba,H.Tominaga,J.Tsuruta,M.,Yokoyama,N.,Izumi,M.,Nagataki,S: "Interleukin-1 inhibits human thyroid carcinoma cell growth." J.Clin Endocrinol Metab.
Description
「研究成果報告書概要(欧文)」より
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[Publications] Namba,H., Kondo,H., Yamashita,S.,Kimura,H.Yokoyama, N., Tsuruta,M., Sato,A.,Izumi,M.Kinoshita,H., Hakariya,S.,Hayashi,K.,Nagataki,S.: "Multiple endocrine neoplasia type 2 with malignant pheochromocytoma.-A Long term follow-up case by ^<131>I-metaiodobenzylguanidine scintigraphy-" Ann Nucl Med. 6. 111-115 (1992)
Description
「研究成果報告書概要(欧文)」より
