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1990 Fiscal Year Final Research Report Summary

The study of molecular mechanism undergoing the development of thyroid cancer

Research Project

Project/Area Number 01570647
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内分泌・代謝学
Research InstitutionNagasaki University School of medicine

Principal Investigator

IZUMI Motonori  Nagasaki University School of Medicine I'Depart. Med associate Prof, 医学部・第一内科, 助教授 (80039552)

Co-Investigator(Kenkyū-buntansha) NAGATAKI Shigeki  Nagasaki University School of Medicine I'Depart. Med. assistant, 医学・第一内科, 助手 (00220062)
Project Period (FY) 1989 – 1990
Keywordsthyroid cancer / oncogene / PTC oncogene / retinoci acid / interleukin 1 / TSH receptor / thyroglobulin / thyroid peroxidase
Research Abstract

Recently a new oncogene PTC has been reported to cause human papillary thyroid carcinoma, therefor we investigated whether this PTC gene exist in thyroid carcinoma using four thyroid cancer cell lines and 22 patients with papillary thyroid carcinoma. PTC gene was detected in only one thyroid carcinoma cell line and was not detect in other three cell lines and the whole 22 patients suggesting that PTC oncogene does not at least in Japan cause thyroid carcinoma.
Thyroid cell line NPA and WRO were investigated to find that ^<125>I TSH could find specfically these cell but TSH could not stimulate CAMP production and that cholexa toxin, forskolin and isoprotenol could stimuilate CAMP productor suggesting some abnormality in Gprotein coupled with TSH receptor. NPA could be stimulated to increase in the uptake of ^3H thymidine by CAMP or forskolin and this increase uptake is inhibited by IL_1 in dore dependent manner, suggesting that IL_1 has antitumorgenecity in some thyroid cancer.

  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] MoRitas,Matsro.K,Tsurutam,Lay,S,Yameshita S.Izumi M.Nagatoki S.: "Stimulotoy effect of retinoei acid on GH gene expresscioni the interation of ratinoie acid and Tri.iodotyronane in rax situitay cells." Jouronul z Endocrinology. 125. 251-256 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Haukewa S,Yamestia S,Tobinagu T,Matso K,Hiragu H,Izumi M,Nagatoki S,Melmeds: "In viho regulation of hepotie inonlin like grouth factor Messenger ibonucleic acids with thyroid homore" Endoeuinsl Japan. 37. 205-211 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Moita S,Yokoyama N,Yamashita S Izumi M.Kanda T.Nagatoki S: "Tradeopathia Osteochoedigloslica Conylicated with thyroidcancer a cose report and review of the litercture in Japan" Japanese Journal of Medicine. 29. 637-641 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagatoki,S Izumi M.Hiraga H: "Radioimmaging of thyroid Tumors" Lbapnolin Orcology. 1. 172-176 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tominaga T,Yamashitu S,Nagayama Y,Morita S,Yokoyan N Izumi M,Nagataki S.: "Interleakin 6 inhibits human tayroid peroxidose gene expressior" Aeth Gndocuinologica. 124. 290-294 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nomber H,Yaneshitu S,Pei HC,Ishikewa N,Villadolid UC,Tominaga T,Kimue H,Tsuruta N Izumi M,Ishigaki J,Ito K,Nagatahi S: "Lack of PTC gene (ret proto oneogene rearayement)in human thyroid Tumor" Endocinol Japan. 38. 627-632 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura H,Yamashita S,Nanba H,Use T,Nishihama T,Fujyama K,Tsuruto M,Yokoyama N,Izumi M Nagataki S,: "Imyaiment of TSH signal transduction system in human Thyoid carcinoma cells" Exp Cell Des in press.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamura H,Yamashita S,Namba H,Tominaga T,Tsuruta M,Yokogawa N Izumi M,Nagaloki S.: "Interleuber 1 inhibils human thyroid ca,cinoma all growth" J clin Endocinol Metab in press.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Namba H.Korda H Yamashi S Kemuro H.Yokagam N.Tsuruta M Sato A Izumi M.Kinoshita H Hekawu S,Hayashi K Nagatoki S.: "Mulyu cndocuine reoplcoua tyyre 2 witl mabgnant Heocbsomoaylona a loy term fallow up case by 131_<-2> metaisdsbenzyl guanidni scuntigrapby" Ann Nud Med. 6. 111-115 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morita,S.Matsuo,K.Tsuruta,M.Leng,S.,Yamahita,S.Izumi,M.Nagataki,S: "Stimulatory effect of retinoic acid on GH gene expression; the interaction of retinoic acid tri-iodthyronine in rat pituitary cells." Journal of Endocrinology. 125. 251-256 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Harakawa,S.Yamashita,S.Tobinaga,T.Matsuo,K.Hirayu,H.Izumi,M.Nagataki,S.,Melmed,S.: "In vivo regulation of hepatic insulin-like grown factor-1 messenger ribonucleic acids with thyroid hormone." Endocrinol Japan. 37. 205-211 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morita,S.Yokoyama,N.Yamashita,S.Izumi,M.Kanda,T.Nagataki,S: "Tracheopathia osteochondroplastis complicated with thyroid, cancer; a case report and review of the literature in Japan." Japanese Journal of Medicine. 29. 637-641 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagataki,S., Izumi,M, Hirayu,H: "Radiommoimaging of thyroid tumors." Diagnostis oncology. 1. 172-176 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tominaga,T.,Yamashita,S.,Nagayama,Y.,Morita,S Yokoyama,N.,Izumi,M.Nagataki S.: "Interleukin 6 inhibits human thyroidase peroxidase gene expression" Acta Endocrinologca. 124. 290-294 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Namba, H.,Yamashita,S.,Pei,HC.,Ishikawa.N.,Villadolid,MC.,Tominaga,T.Kimura,H. Tsuruta;M.Yokoyama.N.Izumi,M., Ishigaki,J, Ito,K.Nagataki.S: "Lack of PTC gene (ret proto-oncogene rearrangement) in human thyroid tumors." Endocrinol Japan. 38. 627-632 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura,H.,Yamashita,S.Namba,H.,Usa.T.,Nishikawa,T.,Fujiyama,K.,Tsuruta,M.,Yokoyama N., Izumi,M.Nagataki,S: "Impairment of TSH signal transduction system in human thyroid carcinoma cells." Exp Cell Res.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura,H.,Yamashita,S.,Namba,H.Tominaga,J.Tsuruta,M.,Yokoyama,N.,Izumi,M.,Nagataki,S: "Interleukin-1 inhibits human thyroid carcinoma cell growth." J.Clin Endocrinol Metab.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Namba,H., Kondo,H., Yamashita,S.,Kimura,H.Yokoyama, N., Tsuruta,M., Sato,A.,Izumi,M.Kinoshita,H., Hakariya,S.,Hayashi,K.,Nagataki,S.: "Multiple endocrine neoplasia type 2 with malignant pheochromocytoma.-A Long term follow-up case by ^<131>I-metaiodobenzylguanidine scintigraphy-" Ann Nucl Med. 6. 111-115 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-03  

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