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1991 Fiscal Year Final Research Report Summary

Experimental and clinical studies on the damage of the brain parenchyma in the disturbance of the cerebrospinal fluid hydrodynamics.

Research Project

Project/Area Number 01570811
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKobe University

Principal Investigator

TAMAKI Norihiko  Kobe University School of Medicine Professor, 医学部, 教授 (10030941)

Co-Investigator(Kenkyū-buntansha) EHARA Kazumasa  Kobe University School of Medicine Research Associate, 医学部, 助手 (20151996)
Project Period (FY) 1989 – 1991
Keywordshydrocephalus / CSF dynamics / periventricular / edema / free water / found water / hemodynamics
Research Abstract

The influence of the disturbance of cerebrospinal fluid dynamics on the damage of the brain parenchyma and the mechanism of hydrocephalic symptoms were studied on the basis of the clinical findings and the experimental investigations. In experimental studies using hydrocephalic models produced by injection of kaolin into the cisterna magna of rabbits and dogs, content of the free water increased and that of the found water decreased in the periventricular white matter at the acute and subacute stages of hydrocephalus. At these stages content of both free and bound water did not change in the cortical gray matter. The ratio of the free to bound water content recovered near the control values. The energy metabolism was deranged in the periventricular white matter at both acute and subacute stages and recovered near the normal state at the chronic stage. In clinical studies the cerebral blood flow of the supratentorial structures decreased in all stages of hydrocephalus. There was also a disturbance of hemodynamics of the cerebellum as a remote effect. There was a recovery of hemodynamics of the cerebrum as well as the cerebellar structures after cerebrospinal fluid shunting. It is suggested from the result of experimental and clinical studies that increase in free water content in the periventricular white matter may produce disturbance of the cerebral energy metabolism and the cerebro-cerebellar blood flow. As a result of these morphological and functional disturbances the clinical symptoms and signs of hydrocephalus may occur.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Tamaki N,Yamashita H Kimura M,Ehara K,Asada M,Nagashima T,Matsumoto S: "Changes in the components and content of biological water in the brain of experimental hydrocephalic rabbits" Journal of Neurosurgery. 73(2). 274-278 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamaki N,Nagashima T,Ehara K,Kimura M,Matsumoto S,Iriguchi N: "Changes in free water content and energy metabolism of the brain in experimental hydrocephalus" Acta Neurochirurgica(Suppl). 51. 354-356 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamaki N,Nagashima T,Ehara K,Shirakuni T,Matsumoto S: "Hydrocephalic oedema in normal-pressure hydrocephalus" Acta Neurochirurgica(Suppl). 51. 348-350 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagashima T,Tada Y,Hamano S,Sakakura M,Masuoka K,Tamaki N,Matsumoto S: "The finite element analysis of brain oedema assosiated with intracranial meningiomas" Acta Neurochirurgica(Suppl). 51. 155-157 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamada H,Oi S,Tamaki N,Matsumoto S,Taomoto K: "Congenital hydrocephalus mimicking Dandy-Walker syndrome induced by 6 aminonicotinamide injection in pregnant rat" Neurologia Medico Chirurgia(Tokyo). 31(6). 326-329 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamada H,Oi S,Tamaki N,Matsumoto S,Sudo K: "Prenatal aqueductal stenosis as a cause of congenital hydrocephalus in the inbred rat LEW/Jms" Child's Nervous System. 7(4). 218-222 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玉木 紀彦: "水頭症 塙 嘉之,三河 春樹,重田 政信編集「今日の小児治療指針」" 医学書院, (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玉木 紀彦、松本 悟: "正常圧水頭症 関野 宏明、佐藤 潔、山浦 晶編集「脳神経外科Quick Referrence」" 文光堂, (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamaki N, Yamashita H, Kimura M, Ehara K, Asada M, Nagashima T, Matsumoto S: "Changes in the component of biological water in the brain of experimental hydrocephalic rabbits." Journal of Neurosurgery. 73. 274-278 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamaki N, Nagashima T, Ehara K, Kimura M, Matsumoto S, Lriguchi N: "Changes in free water content and energy metabolism of the brain in experimental hydrocephalus." Acta Neurochirurgica. (Suppl) 51. 354-356 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamaki N, Nagashima T, Ehara K, Shirakuni T, Matsumot S: "Hydrocephalic oedema in normal-pressure hydrocephalus" Acta Neurochirurgica. (Suppl) 51. 348-350 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagashima T, Tada Y, Hamano S, Sakakura M, Masuoka K, Tamaki N, matsumoto S: "The finite element analysis of brain oedema assosiated with intracranial meningiomas." Acta Neurochirurgica. (Suppl) 51. 155-157 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada H, Oi S, Tamaki N, Matsumoto S, Taomoto K: "Congenital hydrocephalus mimicking Dandy-Walker syndrome induced by 6 aminonicotinamide injection in pregnant rat." Neurologia Medico Chirurgia. 31. 326-329 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada H, Oi S, Tamaki N, Matsumoto S, Sudo K: "Prenatal aqueductal stenosis as a cause of congenital hydrocephalus in the inbred rat LEW/Jms." Child's Nervous System. 7. 218-222 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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