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1990 Fiscal Year Final Research Report Summary

Control of Organ Specific Metastasis

Research Project

Project/Area Number 01570828
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionGunma University

Principal Investigator

UDAGAWA Eiichi  Gunma Univ., Orthopedic Surgery, Professor, 医学部, 教授 (70009976)

Co-Investigator(Kenkyū-buntansha) CHIGIRA Masaki  Gunma Univ., Orthopedic Surgery, Lecturer, 医学部, 講師 (70143196)
Project Period (FY) 1989 – 1990
KeywordsMetastasis / Organ Specificity / Autonomic Growth / Growth Control / Tumor Markers / Bone Metastasis / Screening Test
Research Abstract

Metastasis may be considered to be an no-stochastic process. Proliferation of malignant tumors is based on a internal autonomy of cells. Suppressor factors which are produced by host may not play so important roles in growth control of malignant tumors, since autonomic proliferation of tumor cells is programmed internally. Control mechanism in multicellular organisms is essentially to maintain cell society. Furthermore, tumor heterogeneity is induced by internal evolution of cells.
Tumor markers do not demonstrate prognosis in general, since prognostic factors are complicated. However, the diagnositc value of markers is practically high in screening test for carcinomas. Combination of independent markers is suitable for the diagnosis of them, since false positive results may be excluded using independent markers.

  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] Chigira,M.et al.: "No Correlation between Tumor Markers and Prognaosis under Polygenic Control Systems" Medical Hypotheses. 32. 245-248 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chigira,M.,et al.: "Autonomy in Tumor Cell Proliferation" Medical Hypotheses. 32. 249-254 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chigira,M.& Shinozaki,T.: "Diagnostic Value of Serum Tumor Markers in Skeletal Metastasis of Carcinomas" Arch.Orthop.Traumato.Surg.109. 247-251 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chigira,M.: "Freedom from Wholism in Multicellular Organisms: A Possible role of tumor suppressor genes" Medical Hypotheses.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chigira,M.: "Tumor Progression and Geneーdeletion in the ´neutral´ evolution of Clones" J.Theoretical Biol.

    • Description
      「研究成果報告書概要(和文)」より

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Published: 1993-08-12  

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