1991 Fiscal Year Final Research Report Summary
Effects of low-powered He-Ne laser irradiation on biological membranes and nerve transmission.
| Project/Area Number |
01570858
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | Chiba University |
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Principal Investigator |
IIJIMA Kazuhiko Chiba Univ., Sch. of Med., Dept. of Anesthesiology, Associate Professor, 医学部・麻酔学教室, 助教授 (70009596)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA Yasuichirou Chiba Univ., Sch. of Med., Dept. of Physiology 2nd, Associate Professor, 医学部・第2生理学教室, 助教授 (10009649)
SHIMOYAMA Naohito Chiba Univ., Sch. of Anesthesiology, Staff, 医学部・麻酔学教室, 助手 (40196572)
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| Project Period (FY) |
1989 – 1991
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| Keywords | low power laser / hypotonic hemolysis / membrane stability / red cell deformability / membrane potential / synaptic transmission / threshold of pain / cutaneous blood flow |
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| Research Abstract |
1)The hypotonic hemolysis in human red cells was investigated before and during 30 minute irradiation of low power He-Ne lasers(8.5mW in power). Low power laser beams have a protective effect on damaged red cell membranes from hypotonic hemolysis and stabilize the red cell membrane.
2)The deformability of human red cells was researched using a filter-filtration method with and without irradiation of the lasers. The laser beams improve the function of cytoskeltal proteins in damaged human red cells.
3)Postsynaptic compound action potentials and firing rates in rat cervical ganglions decreased after irradiation of the lasers.
4)Postsynaptic resting membrane potentials were hyperpolarized and electrically stabilized with irradiation of the lasers.
5)Thresholds of electrical stimulation on presynaptic neurons to make firings on postsynaptic neurons were elevated after irradiation of the lasers on sympathetic ganglions.
6)The laser beams recover jaw blood flow during presynaptic stimulations on cervical sympathetic ganglion and depress in sympathetic ganglion transmission.
These results suggest that low power laser beams weaken painful stimulation and suppress firings in peripheral area and normalize the sympathetic tone and biophysical conditions.
Biophotostimulations of low power laser beams appear to maintain homeostasis in living things.
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