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1990 Fiscal Year Final Research Report Summary

The Sensitivity Test for Human Urinary Tract Malignancies Making of use of the Chick Embryo Method using Chorioallantoic Membrane

Research Project

Project/Area Number 01570882
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionKanazawa university

Principal Investigator

UCHIBAYASHI Tadao  Kanazawa University Department of Urology, 医学部・附属病院, 講師 (90151894)

Co-Investigator(Kenkyū-buntansha) UEKI Osamu  Kanazawa University Department of Urology, 医学部附属病院, 助手 (10223447)
Project Period (FY) 1989 – 1990
KeywordsSensitivity test / Urinary tract malignancies / Chick embryo method / MTT method / Molecular biology
Research Abstract

In sensitivity tests of chemotherapy alone, hyperthermia alone, or a combination of the two against human urinary tract malignancies making use of the chick embryo method using chorioallantoic membrane, measurement of the weight of the tumor mass was considered to be an effective method of evaluating the antitumor effect. However, in cases in whicha a large part of the tumor is necrotic, this evaluation method did not provide reliable results. At present, using the the MTT method, more accurate quantitative results have been obtained. As a sensitivity test for metastatic tumors using continuously cultured cell lines, DNA is extracted from the metastatic organs of a fertilized chick embryo, specific DNA amplification and immuno-electro-phoresis are performed, and the DNA content is measured. By this method, it was shown that is possible to quantitatively evaluate the anti-tumor effect of various treatment methods.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 打林 忠雄,他: "鶏卵法による温熱と抗癌剤併用効果の検討" 日本泌尿器科学会雑誌. 80. 17-21 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 西野 昭夫,他: "進行性泌尿器悪性腫瘍の局所温熱療法におけるリンパ球サブセットの検討" 日本ハイパ-サ-ミア誌. 5. 27-36 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yamamoto,et al.: "8MHz radiofrequency hyperthermia for pain relief on advanced urological cancer" Hyperthermic Oncology. 1. 134-135 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中嶋 和喜,他: "浸潤性膀胱癌に対する8MHzーRF局所温熱療法の治療成績" 日本ハイパ-サ-ミア誌. 5. 181-185 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 李 秀雄,他: "電気分解式水素クリアランス法による腎腫瘍および周囲正常組織局所血流量の検討" 日本ハイパ-サ逝ア誌. 5. 375-379 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Uchibayashi,et al.: "Responses of tumor cell lines implanted onto the chorioallantoic membrane of chick embryo to anticancer agents in combination with hyperthermia" Urol.Res.(1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Amano et al: "A combined therapy of hyperthermia and tumor necrosis factor for nude mice bearing kkー47 bladder cancer" J.UroI.144. 370-374 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T. Uchibayashi et al.: "Responses of tumor cell lines and surgical specimens transplanted onto chorioallantoic membrane of chick embryo to anticancer agents in combination with/without hyperthermia" Jpn. J. Urol. 80. 17-21 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A. Nishino et al.: "A study of lymphocyte subsets in patients treated with regional hyperthermia for advanced urological malignancies" Jpn. J. Hyperthermic Oncol. 5. 27-36 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Yamamoto et al.: "8MHz radio frequency hyperthermia for pain relief on advanced urological cancer" Hyperthermic Oncoflogy. 1. 134-135 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Nakajima et al.: "A combined treatment of 8MHz radio-frequency hyperthermia, THP-adriamycin, CDDP or irradiation for invasive bladder carcinoma" Jpn. J. Hyperthermic oncol.5. 181-185 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Lee etal.: "A study of local blood flow in renal cancer and normal tissue using a hydrogen gas clearance method" Jpn. J. Hyperthermic Oncol.5. 375-379 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Amano et al.: "A combined therapy of hyperthermia and tumor necrosis factor for nude mice bearing KK-47 bladder cancer" J. Urol.144. 370-374 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Uchibayashi et al.: "Responses of tumor cell lines implanted onto the chorioallantoic membrane of chick embryo to anticancer agents in combination with hyperthermia" Urol. Res. 1991

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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