1991 Fiscal Year Final Research Report Summary
Anti-tumor activity in regional lymph nodes of the patients with urogenital cancer
| Project/Area Number |
01570895
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Kochi Medical School |
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Principal Investigator |
FUJITA Yukitoshi Kochi Medical School, Urology, Professor, 医学部, 教授 (10033060)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Motoyuki Kochi Medical School, Urology, Assistant, 医学部, 助手 (50220348)
YAMASHITA Akemi Kochi Medical School, Urology, Assistant, 医学部, 助手 (70230414)
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| Project Period (FY) |
1989 – 1991
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| Keywords | Malignant tumor / Regional lymph node / LAK cell / CTL cell |
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| Research Abstract |
1) Although the average of NK activity of regional lymph nodes was 10%, cytotoxicity of LAK cells induced by interleukin-2 from lymph nodes was 20-30%. The cytotoxicity of LAK cells induced from one of them who had lymph node metastasis was the strongest at the condition of less than 20 units/ml of interleukin density and the culture time is from 3 till 5 days.
2) On the subsets of peripheral blood lymphocyte, the number of anti-Leu4(+), antiLeul9(+) cells was not correlated to stage, but decreased at terminal stage. As stage is higher, the cell number of anti-Leu2a(+), HLA-DR(+) was more than that of anti-Leu3a(+), HLA-DR(+) and anti-Leu2a(+) anti-Leul5(+) cells were more than anti-Leu2a(+), anti-Leul5(-) cells.
3) On the subsets of regional lymph node lymphocyte by ABC stain, anti-Leu3a(+) cells were more than. anti-Leu2a(+) cells. Since few anti-Leu7(+), anti-Leull(+) cells were there, its cytotoxicity may be little.
4) On the subsets of 1-lymphocyte around the tumor, anti-Leu7(+), anti-Leull(+) cells were rare and anti-Leu2a(+), anti-Leul5(-) cells were internal and anti-Leu3a(+) cells external.
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