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1990 Fiscal Year Final Research Report Summary

A new approach to the diagnosis of Endometrial Carcinoma - P-450HFLa and PP 4 -

Research Project

Project/Area Number 01570918
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Chiba

Principal Investigator

INABA Noriyuki  University of Chiba Faculty of Medicine, Assistant Prof, 医学部, 講師 (70114238)

Co-Investigator(Kenkyū-buntansha) OKAJIMA Yuko  University of Chida Faculty of Medicine, Instructor, 医学部, 助手 (10203978)
FUKAZAWA Ichio  University of Chiba Faculty of Medicine, Instructor, 医学部, 助手 (00189911)
IWSAKI Hideaki  University of Chiba Faculty of Medicine, Assistant Prof, 医学部, 講師 (60124244)
Project Period (FY) 1989 – 1990
KeywordsEndometrial carcinoma / Oncodevelopmental antigen / Fetal protein / Placental protein / Tumor marker
Research Abstract

Immunohistochemical (ABC method) and immunoserological (EIA) investigations of P-450HFLa and PP4 demonstrated the followings during the period of 1989-1991.1.P-450HFLa
(1) This enzyme was age-dependent immunohistochemically in the human fetal livers, and clearly localized in the human placental villi. P-450HFLa was also localized in 86% of endometrial carcinomas.
(2) Its normal serum upper level was 3 u/ml (mean+2 sigma) . Serum values were not related to menstrual cycles, while the concentrations were elevated in 93% of late pregnancies.
(3) Although its pretherapeutic serum positive rates (>3u/ml) remained 10% in benign gynecologic diseases, the rates were 100% in endometrial carcinomas. 2.PP4
(1) PP4 was demonstrated immunohistochemically in human and cynomolgus placental villi and decidua. This protein was localized clearly in the endometrial stromal cells, while PP4 was demonstrated in 20% of endometrial cancers.
(2) Its normal serum upper limit was 10.9 ng/ml ( mean+2 sigma). Serum concentrations were elevated in the luteal phase and amniotic fluids, and lowered markedly in the late pregnancy.
(3) Its serum positive rates remained 18% in benign gynecologic diseases, but elevated up to 47% even in the 1st stage (FIGO) of endometrial carcinomas.
The above-mentioned data suggest a certain possibility that these two fetoplacental proteins could serve as a tumor marker for endometrial carcinoma.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 深沢 一雄,稲葉 憲之,他: "胎児・胎盤蛋白ーP450HFLaとPP4についてー" Oncology &Chemotuherapy. 5. 324-329 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鎌滝 哲也,稲葉 憲之,他: "新しい標的と抗癌剤耐性しチトクロムPー450" 癌と化学療法. 16. 605-610 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ota Y.Inaba N et al: "Enzym ummunoassay for placental protein 4(PP4) and its possible cliagnostic significance in patients with genital tract cancar" Arch Gynecal Obstet. 247. 139-147 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okajima Y.Inada N.et al: "Immunohistochemical investigation of Pー450HFLa in human and Cynomolgusmonkey placentae" Areh Gynecal Pbstet.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okajima Y.Inaba N.et al: "Immunohistochemical Investigation of Pー450HFLa in gunecologic cliseases." Arch Gynecol Obstet.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okajma Y.Inaba N,et al: "Serum levels of Pー450HFLa in gynecologic diseases" Arch Gynecal Obstet.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukasawa I, Inaba N, et al: "Fetoplacental proteins-P450HFLa and PP4-" Oncology & Chemotherapy. 5. 324-329 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kamataki T, Inaba N, et al: "New chemotherapeutic targets and resistance to chemotherapeutic agents - In relation to cytochrome P-450" Cancer and Chemotherapy. 16. 605-610 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] "Enzyme immunoassay for placental protein 4 (PP4) and its possible diagnostic significance in patients with genital tract cancer" Arch Gynecol Obstet. 247. 139-147 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okajima Y, Inaba N, et al: "Immunohistochemical investigation of P-450HFLa in human and cynomolgus monkey placentae" Arch Gynecol Obstet.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okajima Y, Inaba N, et al: "Immunohistochemical investigation of P-450HFLa in gynecologic diseases" Arch Gynecol Obstet.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okajima Y, Inaba N, et al :"Serum levels of P-450HFLa in gynecologic diseases" Arch Gynecol Obstet.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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