1990 Fiscal Year Final Research Report Summary
Studies on the Immune Function of Patients with Endometriosis
| Project/Area Number |
01570928
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
KANZAKI Hideharu Associate Professor, Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, 医学部, 講師 (80135566)
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| Project Period (FY) |
1989 – 1990
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| Keywords | Endometriosis / Cellular immunity / Subset of lymphocytes / NK activity / Autoantibodies / Cell ELISA |
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| Research Abstract |
Endometriosis has been suggested to be a kind of autoimmune disease, on the basis of recent reports demonstrating that antibodies against the endometrium were detected in patients with endometriosis and that endometriosis may be associated with abnormalities in immune function. To clarify the relationship of endometriosis to the immune dysfunction and presence of antibodies against the surface antigens of endometrial stromal cells, autoantibodies including antiendometrial antibodies, lymphocyte subsets, and levels of immunoglobulins and compliments in peripheral blood of endometriosis patients were investigated. In addition, the effect of patients' sera on natural killer (NK) activity of lymphocytes of healthy male volunteers were examined. The cell ELISA to detect antiendometrial antibodies was established using endometrial stromal cells as antigens which were obtained from hysterectomized uterus. There was no significant difference between the patients with endometriosis and the female controls except for antiendometrial antibodies, indicating that patients with endometriosis are not accompanied with apparent abnormalities in the immune function. However, the NK activity of lymphocytes obtained from volunteers was significantly decreased after 18 hours incubation with sera of endometriosis patients as compared with sera of control women, suggesting the induction of some suppressive factor (s) in sera of endometriosis patients. Present study revealed that some of the endometriosis patients develop antiendometrial antibodies and some serum factor (s) inhibiting NK activity of third party's lymphocytes, however, no obvious immunological deviation detectable by peripheral blood is present in endometriosis.
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[Publications] Kanzaki.H,Sato.S,Mori,T,: "Maternal T bymphoeytes in human olecidualized eudometrium Inc:Deuelopment op proimploutation embry os aud their ekvironment(eds).Yoshinaga,K.E Mori.T).PP,447ー457" Alan R.Liss,Inc.,NY,USA, (474)
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「研究成果報告書概要(和文)」より
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[Publications] Fukuda, A., Mori, Ts., Mori, E., Tatsumi, K., Kanzaki, H. Mori, T.: "Effects of the supernatants of mixed limphocyte cultur and decidual cell line culture on mouse embryo development in vitro." Journal of In Vitro Fertilization and Embryo Transfer. 6. 59-64 (1989)
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「研究成果報告書概要(欧文)」より
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[Publications] Yosida, M., Kanzaki, H., Sato. S., Kriya,. M., Uchida,. A., Kasakura,. S., Mori,. T.: "Detection of immunoregulatory factors in retroplacental serum in human pregnancy" Am. J. Reprod. Immunol.19. 141-145 (1989)
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「研究成果報告書概要(欧文)」より
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[Publications] Yshida, M., Kanzaki, H., Sato, S., Tokushige, M., Mori, T.: "tady on the function of maternal lymphocytes at feto-natermal interface." First Lake Shirakaba Placenta S Conference, ed. Nakayama, T. & Makino, T.106-116 (1989)
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[Publications] Yoshida, M., Kanzaki, H., Kariya, M. Emi, N., Imai, K. Okamoto, N., Uchida, A., Kasakura, S., Mori, T.: "Reduction of interleukin-2-rescptor expression on retroplacental blood lymphocytes in human pregnancy." Am. J. Reprod. Immunol. 22. 1-3 (1990)
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「研究成果報告書概要(欧文)」より
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[Publications] Sato, S., Kanzaki, H., Yohida, M., Tokushige, M., Wang, H. S, Kriya, M., Okamoto, N., Kriya, Y., Uchida, A., Kasakura, S., Mori, T.: "Studies on T-lineage cells in human decidual of first trimester pregnancies." Am. J. Reprod. Immunol.
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[Publications] Kanzaki, H., Crainie, M., Lin, H., Yui, J., Guilbert, L. J., Mori, T., Wegmann T. G.: "The in situ expression of GM-CSF mRNA at the maternal-fatal interface." Growth Factors.
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[Publications] Kriya, M., Kanzaki, H., Tkakura, K., Imai, K., Okamoto, N., Emi, N., Kariya, Y., Mori, T.: "Interleukin-1 inhibits in vitro decidualization of human end metrial stromal cells" J. clin Endocl. Metab.
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[Publications] Okamoto, N., Uchida, A., Takakura, K., Kariya, Y., Kanzaki, H., Riittinen, L., Koistinen, R., Seppala, M., Mori, T.: "Suppression by human placental protein 14 of natural killer cell activaty and T cell proliferative response." J. Clin. Invest.
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[Publications] Imai, K., Maeda, M., Fujiwara, H., Okamoto, N., Kariya, M., Emi, N., Takakura, K., Kanzaki, H., Mori, T.: "Human endometrial stromal cells and decidual cells express aminopeptidase N(CD13 antigen) and neutral endopeptidase (CD 10antigen)" Am. J. Obstet. Gynecol.
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[Publications] Emi, N., Kanzaki, H., Yoshida, M., Takakura, K., Kariya, M., Okamoto, N., Imai, K., Mori, T.: "Lymphocytes stimulates progesterone production by human granulosa luteal cells" Am. J. Obstet. Gynecol.
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