• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1990 Fiscal Year Final Research Report Summary

SOD and Catalase Activity in Oral Cancer Cell Line.

Research Project

Project/Area Number 01571101
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 外科・放射線系歯学
Research InstitutionShowa university

Principal Investigator

SAKURADA Shigeyo  Showa University, Dental School, Assistant Prof., 歯学部, 講師 (00112730)

Co-Investigator(Kenkyū-buntansha) IWASE Masayasu  Showa University, Dental School, Assistant Prof., 歯学部, 講師 (50193743)
Project Period (FY) 1989 – 1990
Keywordscancer cell line / anticancer drugs / superoxide dismutase / catalase / superoxide anion / bleomycin
Research Abstract

The effect of anticancer drugs on superoxide dismutase (SOD) was investigated. Two cancer cell lines were used in this experiment, they are HeLa S3 cells and NA cells which originated from a human squamous cell carcinoma of the tongue, were established as a cell line in our laboratory in 1981. Bleomycin, mitomycin C, cisplatin, and 5-fluorouracil were investigated as anticancer drugs. SOD activity in the cancer cells were found to be enhanced after administration of these drugs ; SOD activity increased in a dose-dependent menner at concentrations from 1.2 to 30 mug/ml of bleomycin, and reached maximam 6 hores after the administration of 2.0 mug/ml of the drug. NaF, a glycolysis inhibitor, enhanced SOD activity both in the presence and absence of bleomycin, while KCN decreased SOD activity significantly. NaF and bleomycin showed and additive effect. These results suggest that SOD activitymay be enhanced by anticancer drugs through several mechanism.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Yukari Gogun: "Enhancement of superoxide dismutase activity in cancer cell lines by anticancer drugs." Journal of Clinical Biochemistry and Nutrition. 8. 85-92 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yukari GOGUN: "Enhancement of superoxide dismutase activity in cancer cell lines by anticancer drugs." J. Clin. Biochem. Nutr.8. 85-92 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1993-08-12  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi