1990 Fiscal Year Final Research Report Summary
Studies on Synthesis of Cyclic Conjugate Diynene Systems
| Project/Area Number |
01571165
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo College of Pharmacy |
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Principal Investigator |
YOKOMATSU Tsutomu Tokyo College of Pharmacy Lecture, 薬学部, 講師 (70158369)
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| Project Period (FY) |
1989 – 1990
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| Keywords | Cyclic conjugate diynene / Bicyclo[3, 3, 1]nonane / Cycloalkene oxide / Vinyl triflate / Alkynylation |
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| Research Abstract |
1) An attempt to synthesize bicyclo [3, 3, 1] nonane systems
Sulfoxide (2) was transformed to acid chloride (4) in several steps. Acylation of 1, 4-dimethoxybenzene by use of 4 in the presence of Lewis acid gave 5 in a miserable yield.
2) A synthesis of conjugate diynene systems (12)
Vinyl triflate (11) was synthesized from cycloalkene oxide (8) as shown in following scheme. Transformation of 11 to 12 is being under investigation.
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