1989 Fiscal Year Final Research Report Summary
Computational Fluid Mechanical Study of the Effects of the Blood Flow in Atherogenesis
| Project/Area Number |
01571243
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
医学一般
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
YAMAGUCHI Takami National Cardiovascular Center, Research Institute, Dept. Vascular Physiology, Chief Scientist, Vascular Pathophysiology Laboratory, 脈管生理部, 室長 (30101843)
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| Co-Investigator(Kenkyū-buntansha) |
HANAI Sotaro National Cardiovascular Center, Research Institute, Dept. Vascular Physiology, S, 脈管生理部, 室員 (20142185)
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| Project Period (FY) |
1989
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| Keywords | Atherosclerosis / Hemodynamic Factor / Wall Shear Stress / Computational Fluid Mechanics Model / Supercomputer |
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| Research Abstract |
Results of a numerical model study of the flow field and the wall shear stress distribution patterns in the vicinity of early atherosclerotic plaques were examined using a computational fluid mechanics method. It was shown from the computation that unsteadiness significantly affected the wall shear stress distribution in the neighborhood of minimal deformations of the arterial wall particularly under unsteady flow conditions. It was also shown that upstream condition did not severely influence the downstream flow structure. In other words, local flow structure was mainly determined by the local geometry. Complexity of flow field invoked by the irregularity of vascular walls was stressed and the necessity of fluid mechanical studies of the blood flow under three dimensional unsteady flow conditions was pointed out. The computational fluid dynamical method incorporating supercomputers was shown to be very useful to understand the fine structure of those flow fields.
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