1990 Fiscal Year Final Research Report Summary
Development of the Shrew (Suncus Murinus) Lines with Robertsonean Fusions Originating from a Wild Population in Sri Lanka
Project/Area Number |
01580042
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Research Category |
Grant-in-Aid for General Scientific Research (C)
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Allocation Type | Single-year Grants |
Research Field |
Laboratory animal science
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Research Institution | The Research Institute of Environmental Medicine, Nagoya University |
Principal Investigator |
ODA Senーichi The Research Institute of Environmental Medicine, Nagoya University, Assistant Professor, 環境医学研究所, 助手 (60023660)
|
Co-Investigator(Kenkyū-buntansha) |
NAMIKAWA Takao School of Agriculture, Nagoya University, Associate Professor, 農学部, 助教授 (70111838)
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Project Period (FY) |
1989 – 1990
|
Keywords | Suncus murinus / Chromosome / Robertsonean fusion / Development of line / Laboratory animal / Insectivore |
Research Abstract |
The results of chromosomal analysis in this study indicate that the laboratory shrew lines can be divided into two types on the basis of chromosome number : the 2N=30 type and the 2N=40 type, representing the smallest and largest respectively, of numbers of chromosomes reported in this species thus far. The 2N=30 type is only found in the SRI line originating from a wild population on the west coast of Sri Lanka. However, the wild shrews caught on the east coast of Sri Lanka have been reported to have 2N=32. These facts provide evidence of chromosomal polymorphism within the wild population of shrews in Sri Lanka. On the other hand, the 2N=40 type is composed of the NAGand OKI lines originating from wild populations in Japan as well as the BAN line from Bangladesh. Matings between SRI (2N=30) and Japanese (2N=40) shrews demonstrated that their Fl, F2 and reciprocal backcross progeny were readily produced. The following chromosome numbers were observed in the hybrids : 2N=35 in Fl shrews, 2N=33 to 2N=38 in F2 shrews and 2N=30 to 2N=38 in reciprocal backcrosses. All the hybrids had the same total of 48 autosomearms. Those Robertsonean lines were developed from them. 9 pairs of metacentric chromosomes, one pair of submetacentric chromosomes and 4 pairs of small acrocentric chromosomes. Furthermore, the metacentric chromosomes could be easily subdivided in to 2 groups : 5 pairsof large metacentric chromosomes and 4 pairs of small metacentric chromosomes. The large metacentric chromosomes which were not found in the 2N=40 type, are believed to have been formed via Robertsonean fusions among 10 pairs of large acrocentric chromosomes seen in the 2N=40 karyotype. We believe that the SRI shrew, as well as the Robertsonean fusion strain mouse, is a useful laboratory animal for chromosome studies.
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[Publications] ISHIKAWA, A., HIRUNAGI, K., ODA, S., NAMIKAWA, T. and TOMITA, T.: "Kinky coat, a new autosomal recessive mutation in the house musk shrew (Suncus murinus, Insectivora)" J. hered.(1991)
Description
「研究成果報告書概要(欧文)」より
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[Publications] ODA, S., ISHIKAWA, A. and NAMIKAWA, T: "Development of unique strains of the house musk shrew, Suncus murinus" The Biology of the Soricidae (Merritt, J., ed.), The Carnegie Museum of National History, Rector, Pennsylvania, USA, 1991.
Description
「研究成果報告書概要(欧文)」より
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[Publications] YOSHIKI, A., HANAZONO, M., ODA, S., WAKASUGI, N., SAKAKURA, T. and KUSAKABE, M.: "Developmental analysis of the eye lens obsolescence (Elo) gene in the mouse : Cell proliferation and Eloーgane expression in the aggregation chimera." Development. (1991)
Description
「研究成果報告書概要(欧文)」より