1991 Fiscal Year Final Research Report Summary
The catalact and microphalmia Rats onset of animal model Breeding and genetical analys with inherited retinal dystrophy
| Project/Area Number |
01580047
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Fujita Health University |
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Principal Investigator |
YAGYU Sigeru Institute for Comprehensive medical science Assistant, 総合医科学研究所, 助手 (10200479)
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| Project Period (FY) |
1989 – 1991
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| Keywords | Retial Dystrophy / Catalact / microphalmia / Congenic strain / RCS / ガラクト-ス |
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| Research Abstract |
The Retinal Dystrophy Rats(RCS/N-rdy/rdy-p/p, RCS/N-rdy/rdy-p/+) were tested for fluorescent fundus angiography.
This test result in retinal caplallary blood vessel were very thin and not crossing. The Retinal caplallary blood vessel dye-leakage and thin appeared in Black Hooded Retinal Dystrophy Rats(RCS/N-rdy/rdy-p/+). The outer nuclear layer is completely lost, but the inner nuclear layer isn't well preserved at 20 Weeks Retinal Dystrophy Rats(RCS/N-rdy/rdy-p/p, RCS/N-rdy/rdy -P/+). A higher incidence of mature cataract in pinkeye(RCS/N-rdy/rdy-p/p) Rats (23%) as compared with black-eyed(RCS/N-rdy/rdy-p/+) Rats (3%). We breeding high incidence of mature cataract in pinkeye Rats (50%) as compared with black-eyed Rats (o%).
Genetical studies revealed that the trait was transmitted recessively by simple facter.
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