1989 Fiscal Year Annual Research Report

拡散集団の起源・系統(自然人類学)

Research Project

Project/Area Number	01643006
Research Institution	Sapporo Medical University
Principal Investigator	百々幸雄札幌医科大学, 医学部, 教授 (50000146)
Co-Investigator(Kenkyū-buntansha)	平井百樹東京大学, 理学部, 助教授 (60156635) 原田勝二筑波大学, 社会医学系, 助教授 (60086618) 徳永勝士東京大学, 医学部, 助手 (40163977) 十字猛夫東京大学, 医学部, 教授 (20009997) 尾本恵市東京大学, 理学部, 教授 (10011503)
Keywords	モンゴロイド / 日本人 / 形質人類学 / 形態小変異 / 人類遺伝学 / HLA / ALDH / DNA
Research Abstract	1.北中国人頭骨171例につき20項目の形態小変異の出現頻度を調査した。統計的分析により、北中国人は渡来系の弥生人以上に古墳時代以降の日本人に近いことが判明した。日本人の起源問題を解明するためには、弥生人の動向を詳細に研究する必要があるという結論を得た(百々)。 2.日本で発見された更新世人類化石である港川人頭骨の形態学的特徴を再検討して、それが数万年前の初原モンゴロイドの状態を留めている可能性を指摘した(馬場)。 3.中国福建省の少数民族ショアの血液160検体につき17種類の遺伝標識を調査した。遺伝距離分析により、ショアは海南島のフイ族に近いが、日本人とはそれほど近くないことを明らかにした(尾本)。 4.中国北京地方漢族100家系と東北地方日本人140家系より得た血液資料について、HLA型を検査しMHCハプロタイプを決定した。この結果と東アジア諸集団のデータに基づいてMHCのハプロタイプの分布を推定すると、祖先集団が日本列島に至る複数の移住ルートの依存が考えられた(十字・徳永)。 5.血液中より精製したDNAを用いて直接ALDHの遺伝子型を検出する方法を開発した。日本人、韓国人および中国人についてALDH遺伝子型検索を行なった結果、人種差を示すデータが得られた(原田・村松)。 6.アジアとアメリカのモンゴロイド諸集団について10標識の遺伝子頻度のデータベースを作成した。これらを画像表示ソフトにより世界地図上に円グラフで表示した(平井)。 7.ミトコンドリアDNAの遺伝的多型データを基に15集団間の遺伝的距離を推定した。その結果、広義のモンゴロイド集団は遺伝的にきわめて近縁であることが判明した(斉藤)。

Research Products
(23 results)

All Other

All Publications (23 results)

[Publications] Ishida H.and Y.Dodo: "Cranial Thickness of the Modern and Neolithic Populations in Japan" Human Biology. 62. (1990)
[Publications] Dodo Y.and H.Ishida: "Population History of Japan as Viewed from Cranial Nonmetric Variation" J.Anthrop.Soc.Nippon. 98. (1990)
[Publications] 尾本恵市,他: "中国少数民族の集団遺伝学的研究 1.海南東のリー,ミャオおよびフイ族" 人類学雑誌.
[Publications] 尾本恵市,他: "中国少数民族の集団遺伝学的研究 2.福建省ショア族" 人類学雑誌.
[Publications] Baba H.,H.Sakura and S.Narasaki: "Human Skeletal Remains of Jomon Period from Minamitsubo ShellーMound Site in Ibaraki Prefecture,East Japan." Bull.Natn.Sci.Mus.,Tokyo,Ser.D. 15. 1-40 (1989)
[Publications] Tokunaga K.et al.: "Comparative Mapping of the Human Major Histocompatibibity Complex in Different Racial Groups by Pulsed Field Gel Electrophoresis." Human Immunology. 26. 99-106 (1989)
[Publications] Tokunaga K.et al.: "Two Ancestral Major Histocompatibibity Complex Haplotypes Carrying Duplicated C4A Genes." Complement and Inflammation. 6. 302 (1989)
[Publications] Tokunaga K.,T.Juji et al.: "Family Study on MHC(HLA)Haplotypes in Chinese and Multiple Migration Routes to Japan." J.Anthrop,Soc.Nippon. 98. (1990)
[Publications] Watanabe Y.,K.Tokunaga,M.Yoshimura,K.Omoto,T.Juji and T.Akazawa: "DNA Analysis on Prehistoric Japanese by PCR:A Preliminary Report" J.Anthrop,Soc.Nippon.98. (1990)
[Publications] Watanabe Y.,K.Tokunaga,K.Matsuki,K.Omoto and T.Juji: "Direct Seguencing of a HLAーDRB Gene by Polymerase Chain Reaction:Seguence Variation in DRW8 Specificity" Japanese J.Human Genetics. 35. (1990)
[Publications] Watanabe Y.,M.Yoshimura,Y.Suzuki,K.Omoto,T.Juji and K.Tokunaga: "DNA Typing for HLAーDR Using Polymerase Chain Reaction:Application to Frozen Blood." J.Anthrop.Soc.Nippon. 98. (1990)
[Publications] Yoshimura M.,Y.Watababe,K.Omoto,K.Tokunaga,and T.Juji: "NonーRadioactive Typing for HLA Genes Using PCR Method." J.Anthrop.Soc.Nippon. 98. (1990)
[Publications] Harada S.: "Polymorphism of Aldehyde Dehydrogenase and its Application to Alcoholism." Int.J.Electrophoresis. 10. 309-318 (1989)
[Publications] Harada S: "Genetic Polymorphism of Aldehyde Dehydrogenase and its Physiological Significance to Alocohol Metabolism." Isozyme. 22. 47-48 (1989)
[Publications] Singh S.,S.Harada et al.: "Inheritance for Mitochondrial Aldehyde Dehydrogenase:Genotyping in Chinese,Japanese and South Korean Families Reveals Deminance of the Mutant Allele." Hum.Genet.83. 119-121 (1989)
[Publications] Muramatsu T.et al.: "Ethanol Patch TestーA Simple and Sensitive Method for Identifying ALDH Phenotype." Alocoholism:Clin.Exp.Res.13. 229-231 (1989)
[Publications] Hirai M.: "Chromosome Studies of the Philippine Negritos." J.Fac:Sci.Univ.Tokyo. 5. 1-54 (1989)
[Publications] Saitou N.and T.Imanishi: "Relative Efficiencise of the FitchーMargoliasch,MaximumーParsimony,MaximumーLikelihood,MinimumーEvolution and NeighborーJoining Methods of Phylogenetic Tree Construction." Molecular Biology and Evolution. 6. 514-525 (1989)
[Publications] Saitou N.and S.Harihara: "Gene Phylogeny and Population Phylogeny Reconstructed from Human Mitochondrial DNA Data." Proceedings of the Circum Pacific Prehistory Congress,Seattle.(1990)
[Publications] Harihara S.and N.Saitou: "A Phylogenetic Analysis of Human Mitochondrial DNA Data." J.Anthrop.Soc.Nippon.97. 483-492 (1989)
[Publications] Saitou N.: "Maximum Likelihood Method." Methods in Enzymology. 183. 584-598 (1990)
[Publications] Saitou N.: "Statistical Methods for Phylogenetic Tree Reconstruction." Hanadbook of Statistics,Volume 8.Rao,C.R.and R.Chakraborty ed.North Holland,New York.(1990)
[Publications] Watanabe T.,N.Miyashita,M.Nishimura,N.Saitou,Y.Hayashi and K.Moriwaki: "Evolutionary Relationships between Laboratory Mice and Subspecies of Mus musculus Based on the Ristriction Fragment Length Variiants of the Chymotrypsin Gene at the Prtー2 Locus." Biochemical Genetics. 27. 119-130 (1989)

1989 Fiscal Year Annual Research Report

拡散集団の起源・系統(自然人類学)

Principal Investigator

百々 幸雄 札幌医科大学, 医学部, 教授 (50000146)

Research Products

[Publications] Ishida H.and Y.Dodo: "Cranial Thickness of the Modern and Neolithic Populations in Japan" Human Biology. 62. (1990)

[Publications] Dodo Y.and H.Ishida: "Population History of Japan as Viewed from Cranial Nonmetric Variation" J.Anthrop.Soc.Nippon. 98. (1990)

[Publications] 尾本恵市,他: "中国少数民族の集団遺伝学的研究 1.海南東のリー,ミャオおよびフイ族" 人類学雑誌.

[Publications] 尾本恵市,他: "中国少数民族の集団遺伝学的研究 2.福建省ショア族" 人類学雑誌.

[Publications] Baba H.,H.Sakura and S.Narasaki: "Human Skeletal Remains of Jomon Period from Minamitsubo ShellーMound Site in Ibaraki Prefecture,East Japan." Bull.Natn.Sci.Mus.,Tokyo,Ser.D. 15. 1-40 (1989)

[Publications] Tokunaga K.et al.: "Comparative Mapping of the Human Major Histocompatibibity Complex in Different Racial Groups by Pulsed Field Gel Electrophoresis." Human Immunology. 26. 99-106 (1989)

[Publications] Tokunaga K.et al.: "Two Ancestral Major Histocompatibibity Complex Haplotypes Carrying Duplicated C4A Genes." Complement and Inflammation. 6. 302 (1989)

[Publications] Tokunaga K.,T.Juji et al.: "Family Study on MHC(HLA)Haplotypes in Chinese and Multiple Migration Routes to Japan." J.Anthrop,Soc.Nippon. 98. (1990)

[Publications] Watanabe Y.,K.Tokunaga,M.Yoshimura,K.Omoto,T.Juji and T.Akazawa: "DNA Analysis on Prehistoric Japanese by PCR:A Preliminary Report" J.Anthrop,Soc.Nippon.98. (1990)

[Publications] Watanabe Y.,K.Tokunaga,K.Matsuki,K.Omoto and T.Juji: "Direct Seguencing of a HLAーDRB Gene by Polymerase Chain Reaction:Seguence Variation in DRW8 Specificity" Japanese J.Human Genetics. 35. (1990)

[Publications] Watanabe Y.,M.Yoshimura,Y.Suzuki,K.Omoto,T.Juji and K.Tokunaga: "DNA Typing for HLAーDR Using Polymerase Chain Reaction:Application to Frozen Blood." J.Anthrop.Soc.Nippon. 98. (1990)

[Publications] Yoshimura M.,Y.Watababe,K.Omoto,K.Tokunaga,and T.Juji: "NonーRadioactive Typing for HLA Genes Using PCR Method." J.Anthrop.Soc.Nippon. 98. (1990)

[Publications] Harada S.: "Polymorphism of Aldehyde Dehydrogenase and its Application to Alcoholism." Int.J.Electrophoresis. 10. 309-318 (1989)

[Publications] Harada S: "Genetic Polymorphism of Aldehyde Dehydrogenase and its Physiological Significance to Alocohol Metabolism." Isozyme. 22. 47-48 (1989)

[Publications] Singh S.,S.Harada et al.: "Inheritance for Mitochondrial Aldehyde Dehydrogenase:Genotyping in Chinese,Japanese and South Korean Families Reveals Deminance of the Mutant Allele." Hum.Genet.83. 119-121 (1989)

[Publications] Muramatsu T.et al.: "Ethanol Patch TestーA Simple and Sensitive Method for Identifying ALDH Phenotype." Alocoholism:Clin.Exp.Res.13. 229-231 (1989)

[Publications] Hirai M.: "Chromosome Studies of the Philippine Negritos." J.Fac:Sci.Univ.Tokyo. 5. 1-54 (1989)

[Publications] Saitou N.and T.Imanishi: "Relative Efficiencise of the FitchーMargoliasch,MaximumーParsimony,MaximumーLikelihood,MinimumーEvolution and NeighborーJoining Methods of Phylogenetic Tree Construction." Molecular Biology and Evolution. 6. 514-525 (1989)

[Publications] Saitou N.and S.Harihara: "Gene Phylogeny and Population Phylogeny Reconstructed from Human Mitochondrial DNA Data." Proceedings of the Circum Pacific Prehistory Congress,Seattle.(1990)

[Publications] Harihara S.and N.Saitou: "A Phylogenetic Analysis of Human Mitochondrial DNA Data." J.Anthrop.Soc.Nippon.97. 483-492 (1989)

[Publications] Saitou N.: "Maximum Likelihood Method." Methods in Enzymology. 183. 584-598 (1990)

[Publications] Saitou N.: "Statistical Methods for Phylogenetic Tree Reconstruction." Hanadbook of Statistics,Volume 8.Rao,C.R.and R.Chakraborty ed.North Holland,New York.(1990)

百々幸雄札幌医科大学, 医学部, 教授 (50000146)