1990 Fiscal Year Final Research Report Summary
Synthetic Study of Heteroaromatic Amides as an Agricultural Drug...
| Project/Area Number |
01850194
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
SUZUKI Hitomi Kyoto University, Department of Chemistry, Professor, 理学部, 教授 (50025342)
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| Co-Investigator(Kenkyū-buntansha) |
KITAHARA Katsuhiko Daikin Industries, LTD., No. 1 Research Department, Senior Research Associate, 主任研究員
UNO Hidemitsu Ehime University, Department of Chemistry, Associate Professor, 助教授 (20168735)
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| Project Period (FY) |
1989 – 1990
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| Keywords | Herbicide / Heteroaromatic Amides / Perfluoroalkyl Group / Three-Component Condensation / Growth-Inhibiting Activity |
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| Research Abstract |
A variety of heteroaromatic amides having a general formula [1] Have been synthesized and their herbicidal activities examined.
After extensive screening for paddy field herbicide, N-[alpha-(2-thienyl)-ethyl]-4-isopropylbenzamide [2] Was found to exhibit a high growth-inhibiting activity toward green and blue algae.
A concise and economical four-step route to amide [2] has been developed starting from cumene and thiophene. A key step involves the direct three-component condensation of 4-isopropylbenzamide, thiophene and paraaldehyde in the presence of formic acid/phosphoric acid.
A novel methodology for introducing perfluoroalkyl group directly into a variety of molecular frames has been developed and successfully employed to the synthesis of fluorine-containing heteroaromatic amides.
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Research Products
(12 results)
