1990 Fiscal Year Final Research Report Summary
A trial to Develop a System for Animal Maintenance Free from Trace Element Contamination
| Project/Area Number |
01870029
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kyoto University |
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Principal Investigator |
ITOKAWA Y. Professor, Dept. of Hygiene, Fac. of Medicine, 医学部, 教授 (80025593)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO H. Instructor. Dept. of Hygiene. Fac. of Medicine, 医学部, 助手 (20205561)
YOKOI K. Instructor, Dept. of Hygiene, Fac. of Medicine, 医学部, 助手 (10200883)
KIMURA M. Asso., Prof. Dept. of Hygiene. Fac. of Medicine, 医学部, 助教授 (60025658)
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| Project Period (FY) |
1989 – 1990
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| Keywords | Trace element / Essentiality / Animal maintenance system |
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| Research Abstract |
Recently use of total parenteral nutrition and synthetic diets leading to essential trace element deficiencies. Lithium, germanium & rubidium are the possible essential trace element with poor documentation. On the other hand although the essentiality of tin & arsenic has been recognized, their specific physiological effect & deficiency symptom are not clear yet. In conventional animal facilities, contamination of these elements has been unavoidable, and therefore the assessment of such unknown essential trace element is impossible. Although recently in United States and Europe controlled animal facilities avoiding such contamination is available, in Japan there is none. Last year we developed such a system introducing special animal cage and food & water container. This year, using this system, we maintained rats with tin, manganese and rubidium deficient diets. Their blood and other tissues were analyzed for essential trace element, and the data were compared with those obtained from rats maintained in conventional facilities. We confirmed the essentiality of tin, produced manganese deficient rats in shorter period, and shed light on the possibility of essentiality of rubidium.
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