• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1991 Fiscal Year Final Research Report Summary

Development of a new cancer therapy using photoexcited semiconductor particles

Research Project

Project/Area Number 01870069
Research Category

Grant-in-Aid for Developmental Scientific Research (B).

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionYokohama City University

Principal Investigator

KUBOTA Yoshinobu  Yokohama City Univ. School of Medicine Associate Professor, 医学部, 助教授 (10106312)

Co-Investigator(Kenkyū-buntansha) FUJISHIMA Akira  The University of Tokyo, Dept. Synthetic Chemistry, Professor, 工学部, 教授 (30078307)
HOSAKA Masahiko  Yokohama City Univ. School of Medicine Professor, 医学部, 教授 (30106330)
Project Period (FY) 1989 – 1991
KeywordsPhoto-chemical reaction / Photoexcited Ti02 / Human cancer cells / Semi-conductor Particles / Human Bladder cancer / Cancer treatment
Research Abstract

Photo-excited Ti02 semiconductor particles can drive various chemical reactions due to their strong oxidizing and reducing ability. To investigate the possible use of this effect for cancer treatment, the anti-tumor activity of photo-excited Ti02 particles were studied in vitro and in vivo. Human cancer cells, like T-24 human bladder cancer cells and HeLa cells, cultured in vitro were completely killed in the presence of Ti02 with photo-irradiation by a 500 W Hg lamp. In cotrast, very little cell death was observed by Ti02 treatment without photo-irradiation. Photoexcited Ti02 particles also suppressed growth of human cancer cells implanted in nude mice significantly, compared with those receiving Ti02 alone or photo-irradiation alone. The cell death caused by photo-excited Ti02 particles was significantly protected in the presence of L-tryptophan and catalase. These molecules are quenchers of hydroxyl radicals(OH^.) and scavengers of hydrogen peroxide (H_2O_2), respectively, suggesting that the cells were killed by the OH^. and H_2O_2 produced from photo-excited Ti02 particles. On the basis of these experimental observation, it can concluded that the cell killing effect of Ti02 under UV light irradiation could be adopted as one of anti-cancer modality.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Cai,R.,Hashimoto,K,Kubota,Y,Fujishima A: "Increment of photocatalytic killing of cancer cells using TiO_2 with the and of superoxide dismutase" Chemistry Letter. 1992. 427-430 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Cai,R.,Kubota,Y.,Shuin,T.,Sakai,H.,Hashimoto.K,and Fujishima,A,: "Induction of cytotoxicity by Photoexcited TiO_2 Particle" Cavcer Research. 52. 2346-2348 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Cai,R.,Hashimoto,K,Kubota,Y,Fujishima.A.: "Conversion of photogenerated superoxide anion into bydrogen peroxide in TiO_2 suspension system" J,Electroanal.,Chem.326. 345-350 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Cai,R.,Hashimoto,K,Ito,K,Kubota,Y,Fujishima,A,: "Photokilling of malignant cells with TiO_2 powder" Bull,Chem,SoC,Japn.64. 1268-1273 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Cai.R.,Sakai,H.Hashimoto,K.,Kubota,Y.,Fujishima,A.: "Phagocytosis of titanium dioxide particles and titanium dioxide particles chemically modified by hematoporphylin" Denki Kagaku. 60. 314-321 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Cai,R., Kubota, Y., Shuin, T., Sakai,H., Hashimoto,K., and Fujishima, A.: "Induction of cytotoxicity by photoexcited Ti02 particles" Cancer Research. 52. 2346-2348 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Cai,R., Hashimoto, K., Kubota, Y., and Fujishima, A.: "Conversion of photogenerated superoxide anion into hydrogen peroxide in Ti02 suspension system" J. Electroanal., Chem.326. 345-350 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Cai,R., Hashimoto, K., Kubota, Y., and Fujishima, A.: "Increment of photocatalytic killing of cancer cells using Ti02 with the aid of superoxide dismutase" Chemistry Letter. 1992. 427-430 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Cai,R., Hashimoto,K.,Ito,K., Kubota, Y., Fujishima, A.: "Photokilling of malignant cells with Ti02 powder" Bull.,Chem.,Sco.,Jpn.64. 1268-1273 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Cai.R., Sakai,H.,Hashimoto, K., Kubota, Y., Fujishima, A.: "Phagocytosis of titanium dioxide particles and titanium dioxide particles chemically modified by hematoporphyrin" Denki Kagaku. 60. 314-319

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1994-03-18  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi