1991 Fiscal Year Final Research Report Summary
Clinical and fornsic medical application of genetic markers in recpients after BMT
| Project/Area Number |
01870117
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Department of Legal Medicine and Human Genetics Jichi Medical School |
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Principal Investigator |
IKEMOTO Shigenori Jichi Medical School M. D., Ph. D. Professor, 医学部, 教授 (90048942)
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| Co-Investigator(Kenkyū-buntansha) |
HUKUI emiko Jichi Medical School M. S. Assistant, 医学部, 助手 (20208341)
TSUCHIDA Shuichi Jichi Medical School M. D., Ph. D. Assistant, 医学部, 助手 (20217326)
IWAMOTO Sadahiko Jichi medical School M. D., Ph. D. Assistant, 医学部, 助手 (10232711)
KAJII Eiji Jichi Medical School M. D., Ph. D. Lecturer, 医学部, 講師 (40204391)
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| Project Period (FY) |
1989 – 1991
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| Keywords | BMT / Gene markers / Transformation / DNA polymrphism / GVHD / Red Cell markers / Forensic Science / Human genetics |
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| Research Abstract |
The outhers report studies on 16 pairs of donors and recipients in bone marrow transplantation(BMT). A broad range of gene markers at approximately 40 gene loci, and DNA polymorphisms(RFLPs and VNTR)were evaluated before and after BMT over 1 and 17 months. As a experimental results, 20 loci genetic markers in recipients were transformed into the donor types. BMT between family members may lead to transformation of gene markers, but within a oattern compatible with family inheritance patterns, and no genetic paradox will be found in later surveys of familial genetic relationships. However, in a personal identification system in legal medicin using genetic markers as an index, the appearance of a phenotype incompatoble with a blood relationship is possible after BMT with a non-blood relative donor. In this result is similar to inheritance pattern observed after artificial insemination by a donor's somen, a more complete out-of family corss. In conclusion, bone marrow transplantation is a treatment modality to which human, geneticists have contributed signifcantly by providing multiple valuable techniques for identification. of the source of. marrow in the transplant patient.
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