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1992 Fiscal Year Final Research Report Summary

Correlation between infection of Opisthorchis veverrini and the Development of hepatitis, liver cirrhosis and hepatic neoplasias.

Research Project

Project/Area Number 02042006
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionNAGOYA CITY UNIVERSITY

Principal Investigator

ITO Nobuyuki  Nagoya City University, 医学部, 教授 (00079956)

Co-Investigator(Kenkyū-buntansha) CHAWALIT PAI  Khon Kean大学, 医学部, 助教授
WITAYA THAMA  Mahidol大学, 医学部, 助教授
ITO Makoto  Nagoay City University, 医学部, 助手 (90137117)
SHIRAI Tomoyuki  Nagoya City University, 医学部, 助教授 (60080066)
THAMAVIT Witaya  Mahidol University
PAIROJKUL Chawalit  Khon Kaen University
Project Period (FY) 1990 – 1992
KeywordsOpisthorchis viverri / Cholangiocellular carcinoma / Thailand / Liver cancer / 発癌物質 / 胆管炎 / 抗タイ肝吸虫抗体
Research Abstract

The northeast area of Thailand where the liver fluke parasite Opisthorchis viverrini (OV) is endemic and economically disadvantaged people eat law fish harboring parasite matacercariae has a high incidence of cholangiocellular cancer. The present investigation was performed to clarify the histopathological characteristics of cholangiocellular carcinomas associated with OV infection, to determine natural carcinogen contamination in foodstuffs, to assess any association with hepatitis virus and to examine predictive value of anti-OV antibodies for early detection of cancer development.
(1) No obvious aflatoxin B1, B2, G1 and G2, sterigmatocystin, ochratoxin, dimethylnitrosamine, or diethylnitrosamine contamination was found by high pressure liquid chromatography or the mass fragment method in the Pla-ra fish sauce prepared in the northeast Thailand.
(2) No association of HVB infection with bile duct carcinoma development in northeastern Thailand was evident from HBs antigen analysis of 93 … More patients with cholangiocellular carcinomas.
(3) Anti-OV antibody was detected in all patients with cholecystitis and/or cholangiocellular carcinomas, higher titers suggesting a higher risk of cancer development.
(4) Proportions of different cholangiocellular tumor types in northeast Thailand were similar to those in Japanese cases except that the medullary type of poorly differentiated tubular adenocarcinoma was only found in Thai patients. Inflammatory reaction in the bile ducts and earlier development of tumors were apparent in association with parasites.
(5) Bile duct ligation enhanced the development of dimethylnitrosamine-initiated hamster cholangiocellular carcinomas, mimicking bile duct obstruction by heavy OV infestation and regenerative epithelial proliferation in man.
(6) Praziquantel, an anthelminthic agent was found to enhance diethylnitrosamine-initiated rat liver carcinogenesis. However, since the effective dose for promotion was extremely high, no adverse effect in man is expected.
In conclusion, prolonged inflammation and regenerative epithelial hyperplasia appear to play important roles in development of cholangiocellular carcinomas in northeast Thailand. Less

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Shirai,T.,et al.: "Promotion of rat hepatocarcinogenesis by praziquantel." Jpn.J.Cancer Res.82. 1085-1088 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shifai,T.et al.: "Histomorphological characteristics of cholangiocellular carcinomas in northeast thailand where a region infection with the liver fluke,opisthorchis viverrini is endemic." Acta Pathologica Japonica. 42. 734-739 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shirai, T., et al.: "Promotion of rat hepatocarcinogenesis by praziquantel." Jpn. J. Cancer Res.82. 1085-1088 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shirai, T., et al.: "Histomorphological characteristics of cholangiocellular carcinomas in northeast thailand where a region infection with the liver fluke, opisthorchis viverrini is endemic." Acta Pathologica Japonica. 42. 734-739 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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