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1992 Fiscal Year Final Research Report Summary

Development of CD Method and Applications to Stereochemistry

Research Project

Project/Area Number 02044014
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionTohoku University

Principal Investigator

HARADA Nobuyuki  Tohoku University, Institute for Chemical Reacti, 反応化学研究所, 教授 (30006324)

Co-Investigator(Kenkyū-buntansha) BENJAMIN ROD  Spain国立研究所, 有機化学研究所(スペイン), 教授
JACEK GAWRON  Adam Mickiewicz大学, 化学教室(ポーランド), 教授
BLACK David St C.  New South Wales University Department of Chemistry (Australia), 化学教室(オーストラリア), 教授
KOREEDA Masato  University of Michigan Department of Chemistry (USA), 化学教室(アメリカ), 教授
NIZAM U.D. K  Aligarh Muslim大学, 化学教室(インド), 講師
NIKOLINA D.  Bulgria科学アカデミー, 有機化学研究所(ブルガリア), 研究員
DAVID A. LIG  Nevada大学, 化学教室(アメリカ), 教授
BEN L. FERIN  Groningen大学, 化学教室(オランダ), 教授
NAKANISHI Koji  Columbia University Department of Chemistry (USA), 化学教室(アメリカ), 教授
RODRIGUEZ Benjamin  CSIC,Institute of Organic Chemistry (Spain)
GAWRONSKI Jacek  Adam Mickiewicz University Department of Chemistry (Poland)
KHAN Nizam U.D.  Aligarh Muslim University Department of Chemistry (India)
LIGHTNER David A.  University of Nevada, Reno Department of Chemistry (USA)
BEROVA Nikolina D.  Bulgaria Academy of Science Institute of Organic Chemistry (Bulgaria)
FERINGA Ben L.  Groningen University Department of Chemistry (Netherlands)
Project Period (FY) 1990 – 1992
KeywordsCD Spectra / CD Exciton Chirality Method / Twisted pi-Electron Systems / Absolute Stereochemistry / Atropisomeric Biflavone / Biscyanine Dye / Absolute Stereostructures of Acyclic Polyols / Chiral Spiro Compounds
Research Abstract

The CD spectroscopic method, together with the X-ray crystallographic method, is useful for determination of the absolute stereostructure of chiral organic compounds. We have proposed, as an extension of the CD exciton chirality method, a new theoretical method for nonempirical determination of the absolute stereochemistry of twisted pi-electron systems. The CD spectra can be theoretically calculated by the pi-electron SCF-CI-DV molecular orbital method, and we have determined the absolute stereostructures of the following biologically active natural products and synthetic chiral organic compounds with theoretical interest.
1.The electronic structure of rho-methoxycinnamate chromophore suitable for application of the CD exciton chirality method to oligosaccharides was clarified.
2.absolute stereochemistry at C-12 in 12-hydroxylated neo-clerodane diterpenoids was determined by CD and X-ray methods.
3.Chiral olefins with molecular asymmetry were synthesized, and their absolute stereostructu … More res were determined by the CD method. the kinetics and mechanism of their photo and thermal racemization were also clarified.
4.CD and absolute stereochemistry of chiral bridged biphenyls were studied.
5.We found that a chiral biscyanine dye exhibits unusually strong exciton split in UV-VIS absorption and CD spectra, and the origin and nature of its unique exciton coupling behavior were clarified.
6.We developed a CD exciton method for determination of the absolute stereochemistry of acyclic 1,3-dibenzoate systems.d the origin and nature of its unique exciton coupling behavior were clarified.
7.Chiral spiroaromatic compounds with 9,9'-spirobifluorene skeleton including[6,6]-vespirene were synthesized and their absolute stereostructures were determined by the CD method.
8.We have succeeded in the first determination of the absolute stereochemistry of atropisomeric biflavone, (-)-4',4''',7,7''-tetra-O-methylcupressuflavone, by theoretical calculation of CD spectra.
9.A chiral probe useful for optical resolution and X-ray crystallographic determination of the absolute stereochemistry of chiral carboxylic acids was developed.
10.We revised, by X-ray crystallographic and CD spectral studies, the absolute stereochemistry of (8)-and(10)-paracyclophane carboxylic acids previously erroneously determined on the basis of chemical correlation. Less

  • Research Products

    (54 results)

All Other

All Publications (54 results)

  • [Publications] N.HARADA: "Total Syntheis and Absolute Stereochemistry of (+)-Xestoquinone and Xestoquinol." Journal of Organic Chemistry. 55. 3158-3163 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "A CD Method for Determination of the Absolute Stereochemistry of Acyclic Glycols.1.Application of the CD Exciton Chirality Method to Acyclic 1,3-Dibenzoate Systems." Journal of the American Chemical Society. 113. 3842-3850 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] D.GARGIULO: "Unique Ultraviolet-Visible and Circular Dichroism Begavior Due to Exciton Coupling in a Biscyanine Dye." Journal of the American Chemical Society. 113. 7046-7047 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.SUZUKI: "Enantioselective Synthesis of the AB Ring Fragment of Gambiertoxin 4B.Implication for the Absolute Configuration of Gambiertoxin 4 and Ciguatoxin." Tetrahedron Letters. 32. 4505-4508 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "Synthesis,Circular Dichroism,and Absolute Stereochemistry of Chiral Spiroaromaic Compounds. 9,9-Spirobifluorene Derivatives." Journal of the Chemical Society,Chemical Communication. 1753-1755 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "Revision of the Structure of Raphanusanins,Phototropism-Regulating Substances of Radish Hypocotyls." Tetrahedron Letters. 32. 6757-6760 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "Revision of the Structure of Raphanusamide,a Phototropism-Regulating Substances of Radish Hypocotyls." Tetrahedron Letters. 32. 6761-6762 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.LOURENCO: "The Absolute Stereochemistry at C-12 in 12-Hydroxylated Neo-Cleridane Diterpenoids." Tetralhedron. 48. 3925-3934 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "Absolute Stereochemistry of(-)-Wieland-Miescher Ketone as Established by the X-Ray Crystallographic and CD Exciton Chirarity Methods." Collection of Czechoslovak Chemical Communications. 57. 1459-1465 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "Atropisomerism in Natural Products. Absolute Stereochemisty of Biflavone,(-)-4′,4〓,7,″-Tetra-O-methylcupressflavone,as Determined by the Theoretical Calculation of CD Spectra." Journal of the American Chemical Cociety. 114. 7687-7692 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.SAKODA: "Structure-Activity Relationship of Raphanusanins and Their Analogues." Phytochemistry. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.BEROVA: "Unique UV-VIS Absorption and Circular Dichroic Exciton-split Spectra of a Chiral Biscyanine Dye. Origin and Nature." Journal of the American Chemical Society. 115. 7687-7692 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 原田 宣之: "化学における右と左" 学術月報. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.KUROKAWA: "Cyclophostin,Acetylcholinesterase Inhibitor from Streptomyces Lavendulae." (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 原田 宣之: "CDスペクトルによる非経験的絶対配置決定:励起子キラリティー法とねじれたパイ電子系法" 有機合成化学協会誌. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "A CD Method for Determination of the Absolute Stereochemistry of Acyclic Glycols. 2.Application of the CD Exciton Chirality Method to Acyclic 1,2-Dibenzoate Systems." (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "Synthesis,Absolute Stereochmistry,and Isolation of (+)-Prehalenaquinone,a Putative Biosynthetic Precursor Common to Halenaquinone and Xestoquinone Compounds." (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "Synthesis,Circular Dichroism,and Absolute Stereochemistry of Chiral Spiro[3.3]heptane Derivatives." (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "A Chiral Probe Useful for Optical Resolution by HPLC,Crytallization,and Determination of Absolute Configuration in X-ray Crystallographic Stracture Analysis." (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "Revision of the Absolute,Stereochemistry of[8]-and[10]-Paracyclophane Carboxylic Acids." (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "Revision of the Absolute Stereochemistry of 1-(9-Phenanthryl)-2-naphthoic Acid." (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "Absolute Stereochenistry of[12]-Naphthalenecyclophane Compounds." (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 原田 宣之: "日本化学会編「実験化学講座(1)-基本操作I」第3章4節,″屈折率と施光度″" 丸善, 14 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 原田 宣之: "日本化学会編「実験化学講座(1)-分光II」第4章6節,″円二色性と磁気円二色性″" 丸善, 22 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "″Circular Dichroism of Twisted π-Electron Systems. Theoretical Determination of the Absolute Stereochemistry of Natural Products and Chiral Synthetic Organic Compounds″." VCH Book, (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "″Studies in Natural Products Chemistry″,′Circular Dichroism,Absolute Stereochemistry,and Total Synthesis of Halenaquinol Compounds,Novel Marine Natural Products Isolated from Tropical Sea Sponges′" Elsevier Science Publishers,Amsterdam, (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.HARADA: "Circular Dichroism Spectroscopy-Exciton Coupling in Organic Stereochemistry-Second Edition" University Science Books,Calif.,and Oxford University Press,Oxford, (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Harada: "Total Syntheis and Absolute Stereochemistry of(+)-Xestoquinone and Xestoquinol." Journal of Organic Chemistry. 55. 3158-3163 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "A CD Method for Determination of the Absolute Stereochemistry of Acyclic Glycosl.1. Application of the CD Exciton Chirality Method to Acyclic 1,3-Dibenzoate Systems." Journal of the American Chemical Society. 113. 3842-3850 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] D.Gargiulo: "Unique Ultraviolet-Visible and Circular Dichroism Behavior Due to Exciton Coupling in a Biscyanine Dye." Journal of the American Chemical Society. 113. 7046-7047 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Suzuki: "Enantioselective Synthesis of the AB Ring Fragment of Gambiertoxin 4B. Implication for the Absolute Configuration of Gambiertoxin 4 and Ciguatoxin." Tetrahedron Letters. 32. 4505-4508 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "Synthesis, Circular Dichoism, and Absolute Stereochemistry of Chiral Spiroaromaic Compounds. 9,9'-spirobifluorene Derivatives." Journal of the Chemical Society, Chemical Communication. 1753-1755 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "Revision of the Structure of Raphanusanins, Phototropism-Regulating Substances of Radish Hypocotyls." Tetrahedron Letters. 32. 6757-6760 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "Revision of the Structure of Raphanusamide, a Phototropism-Regulating Substance of Radish Hypocotyls." Tetrahedron Letters. 32. 6761-6762 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Lourenco: "The Absolute Stereochemistry at C-12 in 12-Hydroxylated Neo-Cleridane Diterpenoids." Tetrahedron. 48. 3925-3934 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "Absolute Stereochemistry of (-)-Wieland-Miescher Ketone as Established by the X-Ray Crystallographic and CD Exciton Chirarity Methods." Collection of Czechoslovak Chemical Communications. 57. 1459-1465 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "Atropisomerism in Natural Products. Absolute Stereochemistry of Biflavone, (-)-4',4111,7,''-Tetra-OMICRON-methylcupressflavone, as Determined by the Theoretical Calculation of CD Spectra." Journal of the American Chemical Society. 114. 7687-7692 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Sakoda: "Structure-Activity Relationship of Raphanusanins and Their Analogues." Phytochemistry. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Berova: "Unique UV-VIS Absorption and Circular Dichroic EXciton-split Spectra of a Chiral Biscyanine Dye. Origin and Nature." Journal of the American Chemical Society. 115. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "Right and Left in Chemistry" Japanese Scientific Monthly. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Kurokawa: "Cyclophostin,Acetylcholinesterase Inhibitor from Streptomyces Lavendulae." (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "Nonempirical Determination of Absolute Stereochemistry by CD Spectroscopy : Methods for Exciton Coupling and Twisted pi-Electron Systems.." (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "A CD Method for Determination of the Absolute Stereochemistry of Acyclic Glycols.2. Application of the CD Exciton Chirality Method to Acyclic 1,2-Dibenzoate Systems." (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "Synthesis, Absolute Stereochemistry, and Isolation of(+)-Prehalenaquinone, a Putative Biosynthetic Precursor Common to Halenaquinone and Xestoquinone Compounds." (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "Synthesis, Circular Dichroism, and Absolute Stereochemistry of Chiral Spiro(3.3)heptane Derivatives." (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "A Chiral Probe Useful for Optical Resolution by HPLC,Crystallization,and Determination of Absolute Coufiguration in X-ray Crystallographic Stracture Analysis." (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "Revision of the Absolute Stereochemistry of[8]- and[10]-Paracyclophane Carboxylic Acids." (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "Revision of the Absolute Stereochemistry of 1-(9-Phenanthryl)-2-naphthoic Acid." (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: "Absolute Stereochemistry of[12]-Naphthalenecyclophane Compounds." (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: Maruzen. Chemical Society of Japan, Ed, "Jikken-Kagaku-Koza", (1), Fundamental Operation I, Chapter 3, Section 4, 'Refractive Index and Optical Rotation', 91-104 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: Maruzen. Chemical Society of Japan, Ed, "Jikken-Kagaku-Koza", (1), Spectroscopy II, Chapter 4, Section 6, 'Circular Dichroism and Magnetic Circular Dichroism', 254-275 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: VCH Book. "Circular Dichroism of Twisted pi-Electron Systems. Theoretical Determination of the Absolute Streochemistry of Natural Products and Chiral Synthetic Organic Compounds"., (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: Elsevier Science Publishers, Amsterdam. "Studies in Natural Products Chemistry", 'Circular Dichroism, Absolute Stereochemistry, and Total Synthesis of Halenaquinol Compounds, Novel Marine Natural Products Isolated from Tropical Sea Sponges', (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Harada: University Science Books, Calif., and Oxford University Press, Oxford. Circular Dichroism Spectroscopy-Exciton Coupling in Organic Stereochemistry-Second Edition, (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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