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1991 Fiscal Year Final Research Report Summary

Clinical application of ultra high field magnetic resonance imaging and spectroscopy

Research Project

Project/Area Number 02044124
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

NARUSE Shoji  Kyoto Prefectural University of Medicine, Lecturer, 医学部, 講師 (50106407)

Co-Investigator(Kenkyū-buntansha) UEDA Satoshi  Kyoto Prefectural University of Medicine, Professor, 医学部, 教授 (40094411)
WEINER Michael W.  University of California, San Francisco ; Professor, サンフランシスコ校.医学部, 教授
UMEDA Masahiro  Meiji College of Oriental Medicine ; Lecturer, 鍼灸学部, 講師 (60223608)
TANAKA Chuzo  Meiji College of Oriental Medicine ; Professor, 鍼灸学部, 教授 (80163541)
Project Period (FY) 1990 – 1991
KeywordsMagnetic resonance imaging (MRI) / Magnetic resonance spectrum (MRS) / Ultra-high field / Chemical shift imaging (CSI) / Diffusion weighted image / Cerebral infarction / Brain edema / Lactate
Research Abstract

The possibility and problems of-obtaining VRI and MRS using a high field system were examined from the basic and technical point of view. The first subject was to design the most appropriate method for localized spectra by using an experimental machine for Animal use (4.7 T and 7.0 T). As the result, the chemical shift imaging (CSI) method is best both for ^1H- and ^<31>P-MRS. According to this result, the second was decided to develop. the ^1H-CSI by resolving various problems as follows. The pulse sequence was designed to get good spectra from small voxels with good localization and with good water suppression The eddy current artifact was compensated by adjusting the dephasing and rephasing gradients. The software for data processing were designed to be that the baseline and phase distortions were corrected automatically and the metabolite mapping was carried out by using the curve-fitted data for each peak. Thus, spectra of 256 voxels with a size of 2.5x2.5x2.5 mm each were obtaine … More d within 50 minutes in the experimental system. In the spectrum of experimentally induced brain ischemia, a N-acetyl aspartate (NAA) peak decreased and a lactate peak increased. The metabolite mapping clearly visualized the changes of the distribution of metabolites in the brain. Since there is still problems in the gradient, system and RF amplifier of the clinical ultra-highs field system, the CSI method was examined by applying to the clinical system now available (1.5 T). As the result, spectra could be obtained from 256 voxels with a sue of lxlx2 cm in the normal and patient brains within 25 minutes. In conclusion, the CSI method is essential for clinical use and it is necessary to continue the research of applying and developing this method for clinical use both in the high-field and ultra-high field systems.
The second suiects is to develop a diffusion weighted imaging method on a high field experimental MRI/S sytem. As an experimental brain edema models, cytotoxic and vasogenic brain edema models were examined using a 4.7 T experimental MR machine. The pulse sequence used was a spin echo method with additional motion-probing gradient (MPG) Pulses. Faster diffusion was detected in the white matter parallel to the direction of MPGS. Slower diffusion was detected perpendicular to MPGS. This indicated that the diffusion anisotropy of myelinated axonal fibers was defined in white matter. A Diffusion weighted image is useful to analyse the various brain disorders. By using the ultra-high field MRI/S system, it is supposed to be possible to obtain the spectroscopic diffusion weighted image which will clarifythe diffusion of various metabolites in the tissue. Less

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 成瀬 昭二: "臨床医のための医用画像診断、MRS。" 臨床画像. 7. 23-34 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 成瀬 昭二: "癌画像診断のトピックス、MRS。" KARKINOS. 4. 1360-1369 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 成瀬 昭二: "MRSによる組織代謝の解析。" 臨床科学. 27. 597-608 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 恵飛須 俊彦: "分子拡散強調MRI画像の脳神経疾患への応用。" 脳と神経. 43. 677-684 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 成瀬 昭二: "脳MRSと代謝情報:正常と病態、 ^1HーMRSと ^1HーCSI" 日本臨床. 49. 1645-1655 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 成瀬 昭二: " ^1HーChemical Shift imaging(CSI)法の臨床応用。" Pharma Medica. 10. 165-172 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shoji NARUSE, Chuzo TANAKA: "Metabolism studied by magnetic resonance spectroscopy in brain : Normal and Abnormal ; ^1H-MRS and ^1H-CSI" Nihon Rinshou. 49. 1645-1655 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shoji NARUSE, Chuzo TANAKA: "Tissue metabolism studied by magnetic resonance spectroscopy" Rinshou Kagaku. 27. 597-608 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shoji NARUSE, Chuzo TANAKA, Seiichi FURUYA: "Topics of diagnostic imaging of cancer ; MRS" KARIKINOS. 4. 1360-1369 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toshihiko EBISU, Shoji NARUSE, Yoshiharu HORIKAWA, et al.: "Application of diffusion weighted images to neurological diseases" No to Shinkei. 43. 677-684 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shoji NARUSE, Seiichi FURUYA: "Clinical application of ^1H-Chemical Shift Imaging (CSI)" Pharma Medica. 10. 165-172 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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