1990 Fiscal Year Annual Research Report

環境要因の人体影響ー人体影響に関与する遺伝的要因

Research Project

Project/Area Number	02202134
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	阿部達生京都府立医科大学, 医学部, 教授 (60079746)
Co-Investigator(Kenkyū-buntansha)	杉山武敏京都大学, 医学部, 教授 (20030851) 西村泰治九州大学, 生体防衛医学研究所, 助教授 (10156119) 野村大成大阪大学, 医学部, 教授 (90089871) 島昭絋東京大学, 理学部, 教授 (60011590) 池永満生京都大学, 放射線生物研究センター, 教授 (70025378)
Keywords	環境変異原 / 優性致死 / 間期死反応 / 特定座位 / <crp>___ー遺伝子 / 染色体異常 / 珪肺症 / HLA
Research Abstract	環境要因を受けとめる個体の遺伝的異質性を評価する方法の確立に努めるとともに,染色体異常,HLAを指標にして遺伝毒性の個体差や特定ハプロタイプと疾病の関連を調べた。1)胸腺等の凍結切片をエリスロシンBで染色することで,微量環境変異原による間期死反応をin vivoで高感度に検出する方法を確立した.間期死反応は,0.01〜0.50Gyの微量X線で直線的に増加した.2)自家開発したメダカ生殖細胞突然変異実験系から,精原細胞の優性致死および生存突然変異は,マウスで得られている優性致死および特定座位突然変異に関する結果とおおむね同等であった.しかし,総突然変異は,メダカに特有の遺伝的指標で生存突然変異より約10倍感度がよかった.3)Xー線で誘発した大腸菌のcrp^ー遺伝子変化をシ-ケンシングによって直接解析したところ,G:C→A:Tへの塩基置換が大部分だった.放射線による突然変異は,遺伝子上でランダムに生じるものと考えられてきたが,今回の成績は突然変異のhot spotの存在を示唆するものであった.4)TopoisomeraseII阻害剤であるetoposideを作用させた正常人末梢血リンパ球では,濃度依存性の染色体異常が観察された.しかし,異常頻度は個体により,10^<ー7>M:0.08〜0.38;5x10^<ー7>M:0.22〜1.34;10^<ー6>M:0.25〜1.93(いずれも細胞当り)と大きく変動することが知られた.SCE誘発を指標にした場合にも同様な結果が得られた.5)珪肺症発症の宿主要因を解明するため,DNAタイピングでHLAーDPの多型解析を行った.珪症症患者55名および健常人につきPCRーSSO法によりDP対立遺伝子多型を同定した.用いたSSOはDPA4種,DPB25種で,日本人健常人315名を検討したところ,DPA2種,DPB13種の対立遺伝子が同定された.珪肺症患者群で有意な増加を示すDPB対立遺伝子は認められず,HLAーBw54ーC4A3B5ーDR4ーDQA10301ーDQB10401(DQw4)ハプロタイプ上に珪肺症の感受性を規定する遺伝子の存在が示唆された.

Research Products

(72 results)

All Other

All Publications (72 results)

[Publications] Inazawa,J,<Abe T>___ー: "Carcinoembryonic antigen(CEA) family genes are located on human chromosome 19 at band q13.2." Acta Histochem Cytochem. 23. 411-422 (1990)
[Publications] Ohe T,Tsuda S,Sakata Y,Taniwaki M,<Misawa S,>___ー <Abe T>___ー: "Cisーdiamminedichloroplatinum(II)ーinduced sisterーchromatid exchanges and chromosome aberration formation in cultured human lymphocytes and their inhibition by sodium thiosulfate." Mutation Res. 244. 279-285 (1990)
[Publications] Taniwaki M,Horiike S,<Misawa S,>___ー <Abe T>___ー,et al.: "Chromosomal abnormalities define clonal proliferation in CD3ーlarge granular lymphocyte leukemia." Am J Hematol. 33. 32-38 (1990)
[Publications] Taniwaki M,Nakagawa H,<Misawa S,>___ー <Abe T>___ー,et al.: "Long arm deletion of chromosome 7 unrelated to original karyotype in recurrent t(8;21) acute myeloblastic leukemia." Acta Haematol. 83. 159-162 (1990)
[Publications] Taniwaki M,Miyagoe K,<Abe T>___ー,et al.: "DNase I seusitive regions on fixed chromosomes by nonradioactive in situ nick translation." J Kyoto Pref Univ Med. 99. 1299-1304 (1990)
[Publications] <Misawa S,>___ー Horiike S,<Abe T>___ー,et al.: "Chromosome abnormalities of gastric cancer detected in cancerous effusions." Jpn J Cancer Res. 81. 148-152 (1990)
[Publications] Fujii H,Yashige H,<Misawa S>___ー,et al: "Ph chromosome in a patient with nonーleukemic nonーHodgkin Bーcell lymphoma." Amer J Hematol. 35. 213-215 (1990)
[Publications] Fujie K,<Maeda S>___ー,<Sugiyama T>___ー,et al.: "Acute cytogenetic effects of tyramine and MTCAs on mouse bone marrow cells in vivo by the micronucleus test." Mutation Res. 240. 19-23 (1990)
[Publications] Fujie K,Nishi J,<Maeda S>___ー,et al.: "Acute cytogenetic effects of tyramine,MTCAs,NaCL and soy sauce on rat bone marrow cells in vivo." Mutation Research. 240. 281-288 (1990)
[Publications] Koizumi T,Nakao Y,<Maeda S>___ー,et al: "Suppression of cー<myc>___ー expression by steroid hormones in human lymphotropic virus typeーIーinduced Tーcell line,KHー2." Int J Cancer. 44. 701-706 (1990)
[Publications] Ishikawa J,<Maeda S>___ー,<Sugiyama T,>___ー et al: "Amplification and overexpression of the epidermal growth factor receptor gene in human renal cell carcinoma." Int J Cancer. 45. 1018-1021 (1990)
[Publications] Mineura K,Fushimi S,<Ikenaga M>___ー,et al: "Linkage between O^6ーmethylguanineーDNA methyltransferase (O^6ーMT) activity and cellular resistance to antitumor nitrosoureas in cultured rat brain tumor cell strains." Acta Neuroshir. 103. 62-66 (1990)
[Publications] Sonoda Y,Okuda T,<MisawaS,>___ー <Abe T>___ー,et al.: "Actions of human interleukinー4/Bーcell stimulatory factorー1 on proliferation and differentiation of enriched hematopoietic progenitor cells in culture." Blood. 75. 1615-1621 (1990)
[Publications] Horiike S,Taniwaki M,<Misawa S,>___ー <Abe T>___ー,et al.: "The unbalanced 1;7 translocation in de novo myelodysplastic syndrome and its clinical implication." Cancer. 65. 1350-1354 (1990)
[Publications] Tagawa S,Doi S,<Abe T>___ー,et al.: "Amylaseーproducing plasmacytoma cell lines,AD3 and FR4,with der(14)t (8__=;14) and dic(8)t(1;8__=) established from ascites." Leukemia. 4. 600-605 (1990)
[Publications] Tanaka S,Nishigaki H,<Abe T>___ー,et al.: "Lack of involvement of the GーCSF gene by chromosomal translocation t(15;17) in acute promyelocytic leukemia." Leukemia. 4. 494-496 (1990)
[Publications] Tanaka S,Nishigaki H,<Misawa S,>___ー <Abe T>___ー,et al: "Reciprocal t(14;19)(q32.3;q13.1)in a patient wity Bーcell lymphoma." Cancer Genet Cytogenet. 49. 219-224 (1990)
[Publications] Inazawa J,Nakagawa H,<Misawa S,>___ー <Abe T>___ー,et al.: "Assignment of the human calpastatin gene (CAST) to chromosome 5 at region q14→q22." Cytogenet and Cell Genet. 54. 156-158 (1990)
[Publications] Kato M,Toguchida J,<Ikenaga M>___ー,et al.: "Elevated frenquency of a specific allele of the Lーmyc gene in male patients with bone and softーtissue sarcomas." Int J Cancer. 45. 47-49 (1990)
[Publications] Ishizaki K,Kato M,<Ikenaga M>___ー,et al.: "Correlation of Lーmyc genotypes to metastasis of gastric cancer and breast cancer." J Natl Cancer Inst. 82. 238-239 (1990)
[Publications] Ishizaki K,Oshimura M,<Ikenaga M>___ー,et al: "Human chromosome 9 can complement UV sensitivity of xeroderma pigmentosum group A cells." Mutation Res. 235. 209-215 (1990)
[Publications] Takimoto K,Uchida K,Ishizaki K,<Ikenaga M>___ー: "Specificity of mutational DAN sequence changes induced by xーray in thecloned <Escherichia coli crp>___ー gene." Mutation Res.
[Publications] <Nomura T>___ー,Gotoh H,Namba T: "An examination of respiratory distress and chromosomal abnormalities in the offspring of male mice treated with ethylnitrosourea." Mutation Res. 229. 115-122 (1990)
[Publications] Yamamoto O,Yokoro K,<Nomura T>___ー,et al.: "HTO oral administration in mice (I) threshold dose rate of haematopoietic death." Int J Radiat Biol. 57. 543-549 (1990)
[Publications] <Nomura T>___ー,Nakajima H,Hatanaka T,et al.: "Embryonic mutation as a possible cause of <in>___ー <utero>___ー carcinogenesis in mice revealed by postnatal treatment with 12ー0ーtetradecanoyl phorbolー13ーacetate." Cancer Res. 50. 2135-2138 (1990)
[Publications] <Nomura T>___ー: "Of mice and men?" Nature. 345. 671 (1990)
[Publications] <Nomura T>___ー,Hayashi T,Matsuyam T,et al.: "Carcinogenicity of sublimed urethane in mice through respiratory tract" Jpn J Cancer Res. 81. 742-746 (1990)
[Publications] <Nomura T>___ー,Takahama Y,Hongyo T,et al.: "SCID(severe combined immunodeficiency) mice as a new system to investigate metastasis of human tumor." J Radiat Res. 31. 287-291 (1990)
[Publications] Ishii Y,Samejima Y,Saji F,<Nomura T>___ー: "Effect of alcohol sulfate,linear alkylbenzene subfonate and natural soap on the development of fertilized eggs of the mouse <in vitro.>___ー" Mutatation Res. 242. 151-155 (1990)
[Publications] <Nomura T>___ー,Hata S,Kusafuka T: "Suppression of developmental anomalies by maternal macrophages in mice" J Exp Med. 172. 1325-1330 (1990)
[Publications] Hayasaka K,Sato M,Mitani H,<Shima A>___ー: "Transfection of cultured fish cells RBCFー1 with exogenous and their resistance to malignant transformation." Comp Biochem Physiol. 96B. 349-354 (1990)
[Publications] Mitani H,Komura J,<Shima A>___ー: "The repair of UVーirradiated plasmids transfected into cultured fish cells." Mutation Res. 236. 77-84 (1990)
[Publications] Sato M,Mitani H,<Shima A>___ー: "Eurythermic growth and synthesis of heat shock proteins of primary cultured glodfish cells." Zool Sci. 7. 395-399 (1990)
[Publications] Chi H,Ishibashi Y,<Shima A>___ー,et al: "Use of DAPI cytofluorometric analysis of cellular DNA content to differentiate Spitz Nevus from malignant melanoma." J Invest Dermatol. 95. 154-157 (1990)
[Publications] Komura L,Mitani H,<Shima A>___ー,et al.: "Preferential excision repair and nonーpreferential photoreactivation of pyrimidine dimers in the cー<ras>___ー sequence of cultured goldfish cells." Mutation Res. (1991)
[Publications] Oda S,Mitani H,Naruse K,<Shima A>___ー: "Synthesis of heat shock proteins in the isolated fin of the Medaka,<Oryzias>___ー <latipes>___ー,acclimated to various temperatures." Comp Biochem Physiol. (1991)
[Publications] Kubota Y,<Shima A>___ー: "Comparative study of embryonic thermoresistance of two inbred strains of the Medaka(<Oryzias latipes>___ー)." J Comp Physiol B. (1991)
[Publications] <Shima A>___ー,Shimada A: "Development of a possible nonmammalian test system for radiationーinduced germーcell mutagenesis using a fish,the Japanese Medaka <Oryzias>___ー <latipes>___ー." Proc Natl Acad Sci USA. (1991)
[Publications] Sasazuki T,Iwanaga T,<Nishimura Y>___ー,et al.: "Expression and function of human major histocompatibility complex HLAーDQw6 genes in the C57BL/6 mouce." Cold Spring Habor Symposium on Quantitative Biology. 54. 513-520 (1990)
[Publications] <Nishimura Y>___ー,Iwanaga T,Sasazuki T,et al.: "Expression of human major histocompatibility complex,HLAーDQw6 genes alters the immune response in C57BL/6 mice." J Immunol. 145. 353-360 (1990)
[Publications] Ottenhoff THM,Walford C,<Nishimura Y>___ー,et al: "HLAーDQ molecules and the control of <Mycobacterium Leprae>___ー specific T cell nonresponsiveness in lepromatous leprosy patients." Eur J Immunol. (1991)
[Publications] Nagafuchi S,Kashiwagi S,<Nishimura Y>___ー,et al: "Reversal of nonーresponders and postexposure prophylaxis by intradermalh apatitis B vaccination in Japanese medical personnel." JAMA. (1991)
[Publications] Kamikawaji N,jujisawa K,<Nishimura Y>___ー,et al: "HLAーDQ restricted CD4+ T cells specific to streptococcal antigen existin low responders but not in high responders." J Immunol. (1991)
[Publications] <阿部達生>___ー: "遺伝子診断の現状." 臨床病理. 38. 1093-1100 (1990)
[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 19.Cystic fibrosis遺伝子(2)ーcDNAの全塩基配列決定と遺伝子診断." 中外医薬. 43. 10-15 (1990)
[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 19.伴性遺伝病(1)ーDMD遺伝子を中心に." 中外医薬. 43. 78-82 (1990)
[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 20.伴性遺伝病(2)ーDMD/BMDおよび他の2,3の疾患." 中外医薬. 43. 147-152 (1990)
[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 21.老化の分子機構(1)ーDown症候群とAlzheimer病." 中外医薬. 43. 221-225 (1990)
[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 22.老化の分子機構(2)ー家族性Alzheimer病." 中外医薬. 43. 291-296 (1990)
[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 23.老化の分子機構(3)ーWerner症候群を中心に." 中外医薬. 43. 350-355 (1990)
[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 24.進化(1)ー染色体進化." 中外医薬. 43. 402-406 (1990)
[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 25.進化(2)ー分子進化." 中外医薬. 43. 467-472 (1990)
[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 26.多型ー中立説の背景,HLAの疾病関連を中心にー." 中外医薬. 43. 538-543 (1990)
[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 27.PCRー診断における技術革命ー." 中外医薬. 43. 595-600 (1990)
[Publications] 横田昇平、<阿部達生>___ー: "Polymerase chain Reacting(PCR)悪性腫瘍診断への応用." 癌と化学療法. 17. 1395-1401 (1990)
[Publications] <阿部達生>___ー: "研究の周辺ー家族性ポリポージスで示された多段階発がん." いずみ. 37. 4-5 (1990)
[Publications] 今西仁、<阿部達生>___ー: "酸化還元系機構とヒト赤血球の加齢." Cytoprotection & Biology. 8. 431-436 (1990)
[Publications] 加納良男,<杉山武敏>___ー: "癌細胞の不死化." Oncologia. 24. 43-53 (1991)
[Publications] <前田盛>___ー,堀尾光三: "ヒトおよび実験白血病における染色体異常と遺伝子." 臨床病理. 38. 509-513 (1990)
[Publications] 藤盛孝博,<前田盛>___ー,他: "大腸腺腫,癌における癌遺伝子産物の免疫染色からみた重複発現について." 医学のあゆみ. 154. 729-730 (1990)
[Publications] <西村泰治>___ー: "HLAーDQトランスジェニックマウス." 医学のあゆみ. 154. 482 (1990)
[Publications] 稲光毅,<西村泰治>___ー: "MHCとself peptide免疫応答におけるself peptideの役割." 実験医学. 8. 77-80 (1990)
[Publications] <西村泰治>___ー: "免疫応答および疾患感受性を支配する遺伝要因." 日本体質学雑誌. 54. 45-47 (1990)
[Publications] 柴村和久,<西村泰治>___ー: "免疫遺伝学からみたスギ花粉症." 科学ー花粉症とその周辺. 61. 93-97 (1991)
[Publications] Inohara H,Nakajima H,<Nomura T>___ー,et al.: "Genetics and pathophysiology of esophageal dilatation developing in a mutant mouse 101/b.Recent advances in bronchoesophacology (Eds.T.Inoue,et al)" Elsevier Sci Publ(Amsterdam), 371-372 (1990)
[Publications] <阿部達生>___ー,谷脇雅史,津田昌一郎: "進行がんの化学療法." 金芳堂, 1-416 (1990)
[Publications] 三谷啓志,小村潤一郎,<嶋昭絋>___ー: "培養細胞を用いたDNA修復研究." メダカの生物学(東京大学出版会), 234-250 (1990)
[Publications] 島田敦子,<嶋昭絋>___ー: "メダカ生殖細胞突然変異.メダカの生物学" 東京大学出版会, 251-266 (1990)
[Publications] 成瀬清,<嶋昭絋>___ー: "人為雌性発生とその利用.メダカの生物学" 東京大学出版会, 281-295 (1990)
[Publications] 岡本安弘,<西村泰治>___ー,笹月健彦: "慢性関節リウマチの理解のために.慢性関節リウマチ" 南江堂, 237-242 (1990)
[Publications] <西村泰治>___ー,笹月健彦: "HLAーDQと免疫抑制.Annual Review" 免疫, 156-164 (1990)
[Publications] <池永満生>___ー: "21世紀中葉までの宇宙開発計画と放射線生物学." 京大原子炉テクニカルレポ-ト KURRI-TRー338, 68-78 (1990)

1990 Fiscal Year Annual Research Report

環境要因の人体影響ー人体影響に関与する遺伝的要因

Principal Investigator

阿部 達生 京都府立医科大学, 医学部, 教授 (60079746)

Research Products

[Publications] Inazawa,J,<Abe T>___ー: "Carcinoembryonic antigen(CEA) family genes are located on human chromosome 19 at band q13.2." Acta Histochem Cytochem. 23. 411-422 (1990)

[Publications] Taniwaki M,Horiike S,<Misawa S,>___ー <Abe T>___ー,et al.: "Chromosomal abnormalities define clonal proliferation in CD3ーlarge granular lymphocyte leukemia." Am J Hematol. 33. 32-38 (1990)

[Publications] Taniwaki M,Nakagawa H,<Misawa S,>___ー <Abe T>___ー,et al.: "Long arm deletion of chromosome 7 unrelated to original karyotype in recurrent t(8;21) acute myeloblastic leukemia." Acta Haematol. 83. 159-162 (1990)

[Publications] Taniwaki M,Miyagoe K,<Abe T>___ー,et al.: "DNase I seusitive regions on fixed chromosomes by nonradioactive in situ nick translation." J Kyoto Pref Univ Med. 99. 1299-1304 (1990)

[Publications] <Misawa S,>___ー Horiike S,<Abe T>___ー,et al.: "Chromosome abnormalities of gastric cancer detected in cancerous effusions." Jpn J Cancer Res. 81. 148-152 (1990)

[Publications] Fujii H,Yashige H,<Misawa S>___ー,et al: "Ph chromosome in a patient with nonーleukemic nonーHodgkin Bーcell lymphoma." Amer J Hematol. 35. 213-215 (1990)

[Publications] Fujie K,<Maeda S>___ー,<Sugiyama T>___ー,et al.: "Acute cytogenetic effects of tyramine and MTCAs on mouse bone marrow cells in vivo by the micronucleus test." Mutation Res. 240. 19-23 (1990)

[Publications] Fujie K,Nishi J,<Maeda S>___ー,et al.: "Acute cytogenetic effects of tyramine,MTCAs,NaCL and soy sauce on rat bone marrow cells in vivo." Mutation Research. 240. 281-288 (1990)

[Publications] Koizumi T,Nakao Y,<Maeda S>___ー,et al: "Suppression of cー<myc>___ー expression by steroid hormones in human lymphotropic virus typeーIーinduced Tーcell line,KHー2." Int J Cancer. 44. 701-706 (1990)

[Publications] Ishikawa J,<Maeda S>___ー,<Sugiyama T,>___ー et al: "Amplification and overexpression of the epidermal growth factor receptor gene in human renal cell carcinoma." Int J Cancer. 45. 1018-1021 (1990)

[Publications] Mineura K,Fushimi S,<Ikenaga M>___ー,et al: "Linkage between O^6ーmethylguanineーDNA methyltransferase (O^6ーMT) activity and cellular resistance to antitumor nitrosoureas in cultured rat brain tumor cell strains." Acta Neuroshir. 103. 62-66 (1990)

[Publications] Sonoda Y,Okuda T,<MisawaS,>___ー <Abe T>___ー,et al.: "Actions of human interleukinー4/Bーcell stimulatory factorー1 on proliferation and differentiation of enriched hematopoietic progenitor cells in culture." Blood. 75. 1615-1621 (1990)

[Publications] Horiike S,Taniwaki M,<Misawa S,>___ー <Abe T>___ー,et al.: "The unbalanced 1;7 translocation in de novo myelodysplastic syndrome and its clinical implication." Cancer. 65. 1350-1354 (1990)

[Publications] Tagawa S,Doi S,<Abe T>___ー,et al.: "Amylaseーproducing plasmacytoma cell lines,AD3 and FR4,with der(14)t (8__=;14) and dic(8)t(1;8__=) established from ascites." Leukemia. 4. 600-605 (1990)

[Publications] Tanaka S,Nishigaki H,<Abe T>___ー,et al.: "Lack of involvement of the GーCSF gene by chromosomal translocation t(15;17) in acute promyelocytic leukemia." Leukemia. 4. 494-496 (1990)

[Publications] Tanaka S,Nishigaki H,<Misawa S,>___ー <Abe T>___ー,et al: "Reciprocal t(14;19)(q32.3;q13.1)in a patient wity Bーcell lymphoma." Cancer Genet Cytogenet. 49. 219-224 (1990)

[Publications] Inazawa J,Nakagawa H,<Misawa S,>___ー <Abe T>___ー,et al.: "Assignment of the human calpastatin gene (CAST) to chromosome 5 at region q14→q22." Cytogenet and Cell Genet. 54. 156-158 (1990)

[Publications] Kato M,Toguchida J,<Ikenaga M>___ー,et al.: "Elevated frenquency of a specific allele of the Lーmyc gene in male patients with bone and softーtissue sarcomas." Int J Cancer. 45. 47-49 (1990)

[Publications] Ishizaki K,Kato M,<Ikenaga M>___ー,et al.: "Correlation of Lーmyc genotypes to metastasis of gastric cancer and breast cancer." J Natl Cancer Inst. 82. 238-239 (1990)

[Publications] Ishizaki K,Oshimura M,<Ikenaga M>___ー,et al: "Human chromosome 9 can complement UV sensitivity of xeroderma pigmentosum group A cells." Mutation Res. 235. 209-215 (1990)

[Publications] Takimoto K,Uchida K,Ishizaki K,<Ikenaga M>___ー: "Specificity of mutational DAN sequence changes induced by xーray in thecloned <Escherichia coli crp>___ー gene." Mutation Res.

[Publications] <Nomura T>___ー,Gotoh H,Namba T: "An examination of respiratory distress and chromosomal abnormalities in the offspring of male mice treated with ethylnitrosourea." Mutation Res. 229. 115-122 (1990)

[Publications] Yamamoto O,Yokoro K,<Nomura T>___ー,et al.: "HTO oral administration in mice (I) threshold dose rate of haematopoietic death." Int J Radiat Biol. 57. 543-549 (1990)

[Publications] <Nomura T>___ー,Nakajima H,Hatanaka T,et al.: "Embryonic mutation as a possible cause of <in>___ー <utero>___ー carcinogenesis in mice revealed by postnatal treatment with 12ー0ーtetradecanoyl phorbolー13ーacetate." Cancer Res. 50. 2135-2138 (1990)

[Publications] <Nomura T>___ー: "Of mice and men?" Nature. 345. 671 (1990)

[Publications] <Nomura T>___ー,Hayashi T,Matsuyam T,et al.: "Carcinogenicity of sublimed urethane in mice through respiratory tract" Jpn J Cancer Res. 81. 742-746 (1990)

[Publications] <Nomura T>___ー,Takahama Y,Hongyo T,et al.: "SCID(severe combined immunodeficiency) mice as a new system to investigate metastasis of human tumor." J Radiat Res. 31. 287-291 (1990)

[Publications] Ishii Y,Samejima Y,Saji F,<Nomura T>___ー: "Effect of alcohol sulfate,linear alkylbenzene subfonate and natural soap on the development of fertilized eggs of the mouse <in vitro.>___ー" Mutatation Res. 242. 151-155 (1990)

[Publications] <Nomura T>___ー,Hata S,Kusafuka T: "Suppression of developmental anomalies by maternal macrophages in mice" J Exp Med. 172. 1325-1330 (1990)

[Publications] Hayasaka K,Sato M,Mitani H,<Shima A>___ー: "Transfection of cultured fish cells RBCFー1 with exogenous and their resistance to malignant transformation." Comp Biochem Physiol. 96B. 349-354 (1990)

[Publications] Mitani H,Komura J,<Shima A>___ー: "The repair of UVーirradiated plasmids transfected into cultured fish cells." Mutation Res. 236. 77-84 (1990)

[Publications] Sato M,Mitani H,<Shima A>___ー: "Eurythermic growth and synthesis of heat shock proteins of primary cultured glodfish cells." Zool Sci. 7. 395-399 (1990)

[Publications] Chi H,Ishibashi Y,<Shima A>___ー,et al: "Use of DAPI cytofluorometric analysis of cellular DNA content to differentiate Spitz Nevus from malignant melanoma." J Invest Dermatol. 95. 154-157 (1990)

[Publications] Komura L,Mitani H,<Shima A>___ー,et al.: "Preferential excision repair and nonーpreferential photoreactivation of pyrimidine dimers in the cー<ras>___ー sequence of cultured goldfish cells." Mutation Res. (1991)

[Publications] Oda S,Mitani H,Naruse K,<Shima A>___ー: "Synthesis of heat shock proteins in the isolated fin of the Medaka,<Oryzias>___ー <latipes>___ー,acclimated to various temperatures." Comp Biochem Physiol. (1991)

[Publications] Kubota Y,<Shima A>___ー: "Comparative study of embryonic thermoresistance of two inbred strains of the Medaka(<Oryzias latipes>___ー)." J Comp Physiol B. (1991)

[Publications] <Shima A>___ー,Shimada A: "Development of a possible nonmammalian test system for radiationーinduced germーcell mutagenesis using a fish,the Japanese Medaka <Oryzias>___ー <latipes>___ー." Proc Natl Acad Sci USA. (1991)

[Publications] Sasazuki T,Iwanaga T,<Nishimura Y>___ー,et al.: "Expression and function of human major histocompatibility complex HLAーDQw6 genes in the C57BL/6 mouce." Cold Spring Habor Symposium on Quantitative Biology. 54. 513-520 (1990)

[Publications] <Nishimura Y>___ー,Iwanaga T,Sasazuki T,et al.: "Expression of human major histocompatibility complex,HLAーDQw6 genes alters the immune response in C57BL/6 mice." J Immunol. 145. 353-360 (1990)

[Publications] Ottenhoff THM,Walford C,<Nishimura Y>___ー,et al: "HLAーDQ molecules and the control of <Mycobacterium Leprae>___ー specific T cell nonresponsiveness in lepromatous leprosy patients." Eur J Immunol. (1991)

[Publications] Nagafuchi S,Kashiwagi S,<Nishimura Y>___ー,et al: "Reversal of nonーresponders and postexposure prophylaxis by intradermalh apatitis B vaccination in Japanese medical personnel." JAMA. (1991)

[Publications] Kamikawaji N,jujisawa K,<Nishimura Y>___ー,et al: "HLAーDQ restricted CD4+ T cells specific to streptococcal antigen existin low responders but not in high responders." J Immunol. (1991)

[Publications] <阿部 達生>___ー: "遺伝子診断の現状." 臨床病理. 38. 1093-1100 (1990)

[Publications] <阿部 達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 19.Cystic fibrosis遺伝子(2)ーcDNAの全塩基配列決定と遺伝子診断." 中外医薬. 43. 10-15 (1990)

[Publications] <阿部 達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 19.伴性遺伝病(1)ーDMD遺伝子を中心に." 中外医薬. 43. 78-82 (1990)

[Publications] <阿部 達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 20.伴性遺伝病(2)ーDMD/BMDおよび他の2,3の疾患." 中外医薬. 43. 147-152 (1990)

[Publications] <阿部 達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 21.老化の分子機構(1)ーDown症候群とAlzheimer病." 中外医薬. 43. 221-225 (1990)

[Publications] <阿部 達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 22.老化の分子機構(2)ー家族性Alzheimer病." 中外医薬. 43. 291-296 (1990)

[Publications] <阿部 達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 23.老化の分子機構(3)ーWerner症候群を中心に." 中外医薬. 43. 350-355 (1990)

[Publications] <阿部 達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 24.進化(1)ー染色体進化." 中外医薬. 43. 402-406 (1990)

[Publications] <阿部 達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 25.進化(2)ー分子進化." 中外医薬. 43. 467-472 (1990)

[Publications] <阿部 達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 26.多型ー中立説の背景,HLAの疾病関連を中心にー." 中外医薬. 43. 538-543 (1990)

[Publications] <阿部 達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 27.PCRー診断における技術革命ー." 中外医薬. 43. 595-600 (1990)

[Publications] 横田 昇平、<阿部 達生>___ー: "Polymerase chain Reacting(PCR)悪性腫瘍診断への応用." 癌と化学療法. 17. 1395-1401 (1990)

[Publications] <阿部 達生>___ー: "研究の周辺ー家族性ポリポージスで示された多段階発がん." いずみ. 37. 4-5 (1990)

[Publications] 今西 仁、<阿部 達生>___ー: "酸化還元系機構とヒト赤血球の加齢." Cytoprotection & Biology. 8. 431-436 (1990)

[Publications] 加納 良男,<杉山 武敏>___ー: "癌細胞の不死化." Oncologia. 24. 43-53 (1991)

[Publications] <前田 盛>___ー,堀尾 光三: "ヒトおよび実験白血病における染色体異常と遺伝子." 臨床病理. 38. 509-513 (1990)

[Publications] 藤盛 孝博,<前田 盛>___ー,他: "大腸腺腫,癌における癌遺伝子産物の免疫染色からみた重複発現について." 医学のあゆみ. 154. 729-730 (1990)

[Publications] <西村 泰治>___ー: "HLAーDQトランスジェニックマウス." 医学のあゆみ. 154. 482 (1990)

[Publications] 稲光 毅,<西村 泰治>___ー: "MHCとself peptide免疫応答におけるself peptideの役割." 実験医学. 8. 77-80 (1990)

[Publications] <西村 泰治>___ー: "免疫応答および疾患感受性を支配する遺伝要因." 日本体質学雑誌. 54. 45-47 (1990)

[Publications] 柴村 和久,<西村 泰治>___ー: "免疫遺伝学からみたスギ花粉症." 科学ー花粉症とその周辺. 61. 93-97 (1991)

[Publications] Inohara H,Nakajima H,<Nomura T>___ー,et al.: "Genetics and pathophysiology of esophageal dilatation developing in a mutant mouse 101/b.Recent advances in bronchoesophacology (Eds.T.Inoue,et al)" Elsevier Sci Publ(Amsterdam), 371-372 (1990)

[Publications] <阿部 達生>___ー,谷脇 雅史,津田 昌一郎: "進行がんの化学療法." 金芳堂, 1-416 (1990)

[Publications] 三谷 啓志,小村 潤一郎,<嶋 昭絋>___ー: "培養細胞を用いたDNA修復研究." メダカの生物学(東京大学出版会), 234-250 (1990)

[Publications] 島田 敦子,<嶋 昭絋>___ー: "メダカ生殖細胞突然変異.メダカの生物学" 東京大学出版会, 251-266 (1990)

[Publications] 成瀬 清,<嶋 昭絋>___ー: "人為雌性発生とその利用.メダカの生物学" 東京大学出版会, 281-295 (1990)

[Publications] 岡本 安弘,<西村 泰治>___ー,笹月 健彦: "慢性関節リウマチの理解のために.慢性関節リウマチ" 南江堂, 237-242 (1990)

[Publications] <西村 泰治>___ー,笹月 健彦: "HLAーDQと免疫抑制.Annual Review" 免疫, 156-164 (1990)

[Publications] <池永 満生>___ー: "21世紀中葉までの宇宙開発計画と放射線生物学." 京大原子炉テクニカルレポ-ト KURRI-TRー338, 68-78 (1990)

阿部達生京都府立医科大学, 医学部, 教授 (60079746)

[Publications] Taniwaki M,Horiike S,<Misawa S,>_ー <Abe T>_ー,et al.: "Chromosomal abnormalities define clonal proliferation in CD3ーlarge granular lymphocyte leukemia." Am J Hematol. 33. 32-38 (1990)

[Publications] Taniwaki M,Nakagawa H,<Misawa S,>_ー <Abe T>_ー,et al.: "Long arm deletion of chromosome 7 unrelated to original karyotype in recurrent t(8;21) acute myeloblastic leukemia." Acta Haematol. 83. 159-162 (1990)

[Publications] <Misawa S,>_ー Horiike S,<Abe T>_ー,et al.: "Chromosome abnormalities of gastric cancer detected in cancerous effusions." Jpn J Cancer Res. 81. 148-152 (1990)

[Publications] Fujie K,<Maeda S>_ー,<Sugiyama T>_ー,et al.: "Acute cytogenetic effects of tyramine and MTCAs on mouse bone marrow cells in vivo by the micronucleus test." Mutation Res. 240. 19-23 (1990)

[Publications] Koizumi T,Nakao Y,<Maeda S>_ー,et al: "Suppression of cー<myc>_ー expression by steroid hormones in human lymphotropic virus typeーIーinduced Tーcell line,KHー2." Int J Cancer. 44. 701-706 (1990)

[Publications] Ishikawa J,<Maeda S>_ー,<Sugiyama T,>_ー et al: "Amplification and overexpression of the epidermal growth factor receptor gene in human renal cell carcinoma." Int J Cancer. 45. 1018-1021 (1990)

[Publications] Sonoda Y,Okuda T,<MisawaS,>_ー <Abe T>_ー,et al.: "Actions of human interleukinー4/Bーcell stimulatory factorー1 on proliferation and differentiation of enriched hematopoietic progenitor cells in culture." Blood. 75. 1615-1621 (1990)

[Publications] Horiike S,Taniwaki M,<Misawa S,>_ー <Abe T>_ー,et al.: "The unbalanced 1;7 translocation in de novo myelodysplastic syndrome and its clinical implication." Cancer. 65. 1350-1354 (1990)

[Publications] Tagawa S,Doi S,<Abe T>_ー,et al.: "Amylaseーproducing plasmacytoma cell lines,AD3 and FR4,with der(14)t (8=;14) and dic(8)t(1;8__=) established from ascites." Leukemia. 4. 600-605 (1990)

[Publications] Tanaka S,Nishigaki H,<Misawa S,>_ー <Abe T>_ー,et al: "Reciprocal t(14;19)(q32.3;q13.1)in a patient wity Bーcell lymphoma." Cancer Genet Cytogenet. 49. 219-224 (1990)

[Publications] Inazawa J,Nakagawa H,<Misawa S,>_ー <Abe T>_ー,et al.: "Assignment of the human calpastatin gene (CAST) to chromosome 5 at region q14→q22." Cytogenet and Cell Genet. 54. 156-158 (1990)

[Publications] Takimoto K,Uchida K,Ishizaki K,<Ikenaga M>_ー: "Specificity of mutational DAN sequence changes induced by xーray in thecloned <Escherichia coli crp>_ー gene." Mutation Res.

[Publications] <Nomura T>_ー,Nakajima H,Hatanaka T,et al.: "Embryonic mutation as a possible cause of <in>_ー <utero>___ー carcinogenesis in mice revealed by postnatal treatment with 12ー0ーtetradecanoyl phorbolー13ーacetate." Cancer Res. 50. 2135-2138 (1990)

[Publications] Ishii Y,Samejima Y,Saji F,<Nomura T>_ー: "Effect of alcohol sulfate,linear alkylbenzene subfonate and natural soap on the development of fertilized eggs of the mouse <in vitro.>_ー" Mutatation Res. 242. 151-155 (1990)

[Publications] Komura L,Mitani H,<Shima A>_ー,et al.: "Preferential excision repair and nonーpreferential photoreactivation of pyrimidine dimers in the cー<ras>_ー sequence of cultured goldfish cells." Mutation Res. (1991)

[Publications] Oda S,Mitani H,Naruse K,<Shima A>_ー: "Synthesis of heat shock proteins in the isolated fin of the Medaka,<Oryzias>_ー <latipes>___ー,acclimated to various temperatures." Comp Biochem Physiol. (1991)

[Publications] Kubota Y,<Shima A>_ー: "Comparative study of embryonic thermoresistance of two inbred strains of the Medaka(<Oryzias latipes>_ー)." J Comp Physiol B. (1991)

[Publications] <Shima A>_ー,Shimada A: "Development of a possible nonmammalian test system for radiationーinduced germーcell mutagenesis using a fish,the Japanese Medaka <Oryzias>_ー <latipes>___ー." Proc Natl Acad Sci USA. (1991)

[Publications] Ottenhoff THM,Walford C,<Nishimura Y>_ー,et al: "HLAーDQ molecules and the control of <Mycobacterium Leprae>_ー specific T cell nonresponsiveness in lepromatous leprosy patients." Eur J Immunol. (1991)

[Publications] <阿部達生>___ー: "遺伝子診断の現状." 臨床病理. 38. 1093-1100 (1990)

[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 19.Cystic fibrosis遺伝子(2)ーcDNAの全塩基配列決定と遺伝子診断." 中外医薬. 43. 10-15 (1990)

[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 19.伴性遺伝病(1)ーDMD遺伝子を中心に." 中外医薬. 43. 78-82 (1990)

[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 20.伴性遺伝病(2)ーDMD/BMDおよび他の2,3の疾患." 中外医薬. 43. 147-152 (1990)

[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 21.老化の分子機構(1)ーDown症候群とAlzheimer病." 中外医薬. 43. 221-225 (1990)

[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 22.老化の分子機構(2)ー家族性Alzheimer病." 中外医薬. 43. 291-296 (1990)

[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 23.老化の分子機構(3)ーWerner症候群を中心に." 中外医薬. 43. 350-355 (1990)

[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 24.進化(1)ー染色体進化." 中外医薬. 43. 402-406 (1990)

[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 25.進化(2)ー分子進化." 中外医薬. 43. 467-472 (1990)

[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 26.多型ー中立説の背景,HLAの疾病関連を中心にー." 中外医薬. 43. 538-543 (1990)

[Publications] <阿部達生>___ー: "細胞遺伝学,分子遺伝学と日常の臨床 27.PCRー診断における技術革命ー." 中外医薬. 43. 595-600 (1990)

[Publications] 横田昇平、<阿部達生>___ー: "Polymerase chain Reacting(PCR)悪性腫瘍診断への応用." 癌と化学療法. 17. 1395-1401 (1990)

[Publications] <阿部達生>___ー: "研究の周辺ー家族性ポリポージスで示された多段階発がん." いずみ. 37. 4-5 (1990)

[Publications] 今西仁、<阿部達生>___ー: "酸化還元系機構とヒト赤血球の加齢." Cytoprotection & Biology. 8. 431-436 (1990)

[Publications] 加納良男,<杉山武敏>___ー: "癌細胞の不死化." Oncologia. 24. 43-53 (1991)

[Publications] <前田盛>___ー,堀尾光三: "ヒトおよび実験白血病における染色体異常と遺伝子." 臨床病理. 38. 509-513 (1990)

[Publications] 藤盛孝博,<前田盛>___ー,他: "大腸腺腫,癌における癌遺伝子産物の免疫染色からみた重複発現について." 医学のあゆみ. 154. 729-730 (1990)

[Publications] <西村泰治>___ー: "HLAーDQトランスジェニックマウス." 医学のあゆみ. 154. 482 (1990)

[Publications] 稲光毅,<西村泰治>___ー: "MHCとself peptide免疫応答におけるself peptideの役割." 実験医学. 8. 77-80 (1990)

[Publications] <西村泰治>___ー: "免疫応答および疾患感受性を支配する遺伝要因." 日本体質学雑誌. 54. 45-47 (1990)

[Publications] 柴村和久,<西村泰治>___ー: "免疫遺伝学からみたスギ花粉症." 科学ー花粉症とその周辺. 61. 93-97 (1991)

[Publications] <阿部達生>___ー,谷脇雅史,津田昌一郎: "進行がんの化学療法." 金芳堂, 1-416 (1990)

[Publications] 三谷啓志,小村潤一郎,<嶋昭絋>___ー: "培養細胞を用いたDNA修復研究." メダカの生物学(東京大学出版会), 234-250 (1990)

[Publications] 島田敦子,<嶋昭絋>___ー: "メダカ生殖細胞突然変異.メダカの生物学" 東京大学出版会, 251-266 (1990)

[Publications] 成瀬清,<嶋昭絋>___ー: "人為雌性発生とその利用.メダカの生物学" 東京大学出版会, 281-295 (1990)

[Publications] 岡本安弘,<西村泰治>___ー,笹月健彦: "慢性関節リウマチの理解のために.慢性関節リウマチ" 南江堂, 237-242 (1990)

[Publications] <西村泰治>___ー,笹月健彦: "HLAーDQと免疫抑制.Annual Review" 免疫, 156-164 (1990)

[Publications] <池永満生>___ー: "21世紀中葉までの宇宙開発計画と放射線生物学." 京大原子炉テクニカルレポ-ト KURRI-TRー338, 68-78 (1990)