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1992 Fiscal Year Final Research Report Summary

Quantitative Evaluation of Reaction Paths and Its Application for the Prediction and the Design of Reactions.

Research Project

Project/Area Number 02303004
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 有機化学一般
Research InstitutionFaculty of Engineering, Yokohama National University

Principal Investigator

HIROTA Minoru  Professor, Department of Synthetic Chemistry Yokohama National University, 工学部, 教授 (00017881)

Co-Investigator(Kenkyū-buntansha) OKAZAKI Renji  Professor, Department of Chemistry University of Tokyo, 教授 (70011567)
ANDO Wataru  Professor, Department of Chemistry University of Tsukuba, 化学系, 教授 (30008429)
TAKEUCHI Kenichi  Professor, Department of Petroleum Chemistry Kyoto University, 工学部, 教授 (50026358)
TSUNO Yuho  Professor, Department of Chemistry Faculty of Science, Kyushu University, 理学部, 教授 (10029845)
MOROKUMA Keiji  Professor, Institute for Molecular Sciences, 教授 (40111083)
Project Period (FY) 1990 – 1992
KeywordsReaction Mechanism / Reaction Design / Transition State / Reactive Intermediate / Reaction Kinetics / Steric Effect / Molecular Interaction / Heteroatom Compound
Research Abstract

This co-operative research has been carried out by organizing four subbgroups. (1)Electronic Aspects of Reaction mechanism and Path The reaction paths of the cyclization of penta-1,4-dienes and the additions to fullerene were elucidated theoretically by ab initio MO calculations. On the other hand, the resonance demands in the solvolysis of benzyl derivatives were analyzed very exactly and correlated to its mechanism. Molecular interactions involved in the organic reaction mechanism were studied both from theoretical and kinetical points of view.
(2)Steric Course and Stereoselectivity of Reactions By use of molecular mechanics, steric hindrance was evaluated quantitatively and the steric course of the reactions of trishomocubanes was estimated. The sterically congested reaction field was desigened in STECAR concept and in the BINAP-RU hydrogenation.
(3)Structures and Interactions in Reaction Intermediates The structures and properties of stable cations, such as alpha-arylvinyl cation and bicyclic alpha-keto-cations, and polyradicals were elucidated. In contrast, very fast electron transfer rection and very short-lived photo-excited states were identified by laser photolysis and other new techniques. Sonochemical method was applied to the switching of reactions.
(4)Reactions of Heteroatom-Cntaining and Biological Molecules Silicenium ions, polysilacyclo- alkynes, hypervalent compounds, chiral bismuthines, [3,3]metacylophanes, and other novel compounds were designed and their applications were pursued. On the other hand, reaction mechanisms of model enzymes were studied kinetically.

  • Research Products

    (47 results)

All Other

All Publications (47 results)

  • [Publications] T.Komatsuzaki,I.Akai,K.Sakakibara,M.Hirota: "A New Steric Substituent Constant Ωs.Characteristic Feature and Comparison with Some Other Steric Constants." Tetrahedron. 48. 1539-1556 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] I.Akai,K.Sakakibara,M.Hirota: "The Ωs Constant for Polar Substituents.Reinvestigation on the Separation of the Steric and the Polar Effects." Chemistry Letters. 1992. 1317-1320 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Nakamura,Y.Miyachi,N.Koga,K.Morokuma: "Theoretical Studies of Heteroatom-Directed Carbometallation.Addition of MeCu,Me2cu-and Meli to Acetylenes." Journal of American Chemical Society. 114. 6686-6694 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Nagase,K.Kobayashi,M.Nagashima: "The Heavier Group 14 Analogues of the Bicyclo[l.l.O]butane Radical Cations.A Theoretical Study." Journal of Physical Chemistry. 96. 9189-9194 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] O.S.Lee,Osawa: "An Explanation for the Contrasting Reactivities of meso- and d,l--D_3-Trishomocubylidene-D_3-trishomocubane towards Electrophiles" Bulletin of the Korean Chemical Society. 13. 59-64 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Honda,K.Kitaura,K.Nishimoto: "Theoretical Study of Structure and thermodynamic Properties of Liquid Hydrogen Fluoride." Bulletin of the Chemical Society of Japan. 65. 3122-3134 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Fujio,K.Nakashima,E.Tokunage,Y.Tsuji,Y.Tsuno: "The Unexalted Resonance Scale of Substituent Effect in the Benzylic Solvolysis" Tetrahedron Letters. 33. 345-348 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yamataka,K.Nagareda K.Ando,T.Hanafusa: "Relative Reactivity and Stereoselectivity in the wittig Reactions of Substitued Benzaldehydes with Benzylidenetriphenylphosphorane." Journal of Organic Chemistry. 57. 2865-2870 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Kawamoto,M.Tomishima,F.Yoneda,J.Hayami: "Synthesis and Reaction of Novel 5-Deazaflavins with Axial chirarity at Pyrimidine Ring Moiety." Tetrahedron Letters. 33. 3169-3172 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Cosstick,T.Asano,N.Ohno: "Pressure-Induced Retardation of Steric Isomerizations in Highly Viscous Media" Proceedings of XIII AIRAPT Interantional Conference on High Pressure Science and Technology. 556-558 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Okuyama,T.Fueno: "Dual Rcactivity of Methoxymethyl Benzenesulfenate in Nucleophilic Substitution." Bulletin of the Chemical Society Japan. 65. 2672-2683 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Kitamura,M.Tokunaga,R.Noyori: "Practical Synthesis of BINAP-Ruthenium(II)." Journal of Organic Chemistry. 57. 4053-4054 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Tezuka,Y.Isahaya: "The STECAR (Steric Compression-assisted Reaction) Concept.Ionic Deoxygenation Reaction via Intramolecular Proton Shift in Bornyl α-azo-hydroperoxide to give Camphor Hydrazone." Tetrahedron Letters. 32. 4955-4958 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Nishida,N.Asanuma,T.Tsuji,T.Imai,M.Murakami: "Reactions of Spiro[2.4]hept-4-ene Dreivatives with tetracyano-ethylene.Occurrence of the Type II reaction in Some Disubsti-tuted Substrates." Journal of Organic Chemistry. 57. 4658-4663 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Kitamura,T.Takachi,H.Kawamoto,H.Taniguchi: "Electrophile-Induced Intramolecular Cyclization of ortho-(Aryloxy)-phenylalkynes to Dibenzo[b,f]oxedines." Journal of Chemical Society,Perkin Trans.1. 1992. 1969-1975 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Takeuchi,Y.Ohga,T.Kitagawa,M.Yoshida,A.Tsugeno: "Solvolysis of 2-Methylene Bridgehead Derivatives:A Model for Gradual Variation of π-Conjugation in Carbocation." Journal of Organic Chemistry. 57. 280-289 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toshi Nagata: "Synthesis and Characterization of Doubly-Strapped porphyrins." Bulletin of the Chemical Society of Japan. 65. 385-391 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] I.K.Ledney,M.V.Alfimov,Y.Kuriyama,T.Arai,H.Sakuragi,K.Tokumaru: "Photosensitized cis-trans Isomerization of Stilbene via Cation Radical Mechanism in Micellar Solution." Journal of Photochemistry & Photobiology A:Chem.63. 201-209 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] G.Yamamoto,H.Higuchi,H.Yamamoto,J.Ojima: "1H and 13C Spectral Behavior and Isomerism in bisdehydro[15] annulenones." Bulletin of the Chemical Society of Japan. 65. 2388-2394 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] W.Ando,F.Hojo,S.Sekigawa,N.Nakajima,T.Shimizu: "First Isolation of Six-Membered Cyclic Acetylene:Synthesis and Reaction of Tetrasilacyclonexynes." Organometallics. 11. 1009-1020 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Ohkata,M.Ohnishi,K.Yoshinaga,K.Akiba,J.C.Rongipne,J.C.Martin: "Apical and Equatorial Methoxy Ligands on Sulfuranes:Effect on Rates of Pyridine Methylation" Journal of American Chemical Society. 113. 9270-9276 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Matano,M.Kinoshita,H.Suzuki: "Synthesis and Reactions of Some Crowded Triorganyl Bismuthies." Bulletin of the Chemical Society of Japan. 65. 3504-3511 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Takemura,T.Shinmyozu,T.Inazu: "Syntheses and Properties of Highly Symmetrical Cage Compounds:Pyridine Analogues of Hexa-m-xylyleneteramine" Journal of American Chemical Society. 113. 1323-1331 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Ohno,M.Okamura,T.Kashiwagi,Y.Mikata,N.Yamazaki: "Stereospecific Electrochemical Oxidation of NAD(P)H Analogs Mediated by Radical Cation of Anilines." Chemistry Letters. 1992. 1247-1250 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T. Komatsuzaki, I. Akai, K. Sakakibara, M. Hirota: "A New Steric Substituent Constant OMEGAs. Characteristic Feature and Comparison with Some Other Steric Constants." Tetrahedron. Vol.48. 1539-56 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I. Akai, K. Sakakibara M. Hirota: "The OMEGAs Constant for Polar Substituents. Reinvestigation on the Separation of the Steric and the Polar Effects." Chemistry Letters. Vol.1992. 1317-1320

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E. Nakamyra, Y. Miyachi N. Koga, K. Morokuma: "Theoretical Studies of Heteroatom-Directed Carbometallation. Addition of MeCu, Me2Cu- and MeLi to Acetylenes." Journal of American Chemical Society. Vol.114. 6686-6694 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Nagase, K. Kobayashi M. Nagashima: "The Heeavier Group 14 Analogues of the Bicycle[1.1.0]butane Radical Cations. A Theoretical Study." Journal of Physical Chemistry. Vol.96. 9189-9194 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] O. S. Lee, E. Osawa: "An Explanation for the Contrasting Reactivities of meso- and d,1--D_3-Trishomocubylidene-D_3-trishomocubane towards Electrophiles" Bulletin of the Korean Chemical Society. Vol.13. 59-64 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Honda, K. Kitaura, K. Nishimoto: "Theoretical Study of Structure and thermodynamic Properties of Liquid Hydrogen Fluoride." Bulletin of the Chemical Society of Japan. Vol.65. 3122-3134 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Fujio, K. Nakashima, E. Tokunaga, Y. Tsuji, Y. Tsuno: "The Unexalted Resonance Scale of Substituent Effect in the Benzylic Solvolysis" Tetrahedron Letters. Vol.33. 345-348 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Yamataka, K. Nagareda K. Ando, T. Hanafusa: "Relative Reactivity and Stereoselectivity in the Wittig Reactions of Substitued Benzaldehydes with Benzylidenetriphenylphosphorane." Journal of Organic Chemistry. Vol.57. 2865-2870 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Kawamoto, M.Tomishima F. Yoneda, J. Hayami: "Synthesis and Reaction of Novel 5-Deazaflavins with Axial chirarity at Pyrimidine Ring Moiety." Tetrahedron Letters. Vol.33. 3169-3172 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Okuyama, T. Fueno: "Dual Reactivity of Methoxymethyl Benzenesulfenate in Nucleophilic Substitution." Bulletin of the Chemical Society Japan. Vol.65. 2672-2673 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Kitamura, M. Tokunaga, R. Noyori: "Practical Synthesis of BINAP-Ruthenium(II)." Journal of Organic Chemistry. Vol.57. 4053-4054 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Tezuka, Y. Isahaya: "The STECAR (Steric Compression-assisted Reaction) Concept. Ionic Deoxygenation Reaction via Intramolecular Proton Shift in Bornyl alpha-azo-hydroperoxide to give Camphor Hydrazone." Tetrahedron Letters. Vol.32. 4955-4958 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Nishida, N. Asanuma T. Tsuji, T. Imal M. Murakami: "Reactions of Spiro[2.4]hept-4-ene Dreivatives with tetracyano-ethylene. Occurrence of the Type II reaction in Some Disubsti-tuted Substrates." Journal of Organic Chemistry. Vol.57. 4658-4663 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Kitamura,T. Takachi, H. kawamoto H. Taniguchi: "Electrophile-Induced Intramolecular Cyclization of ortho-(Aryloxy)-phenylalkynes to Dibenzo[b,f]oxepines." Journal of Chemical Society, Perkin Trans.1. Vol.1992. 1969-1975

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Takeuchi, Y. Ohga, T. Kitagawa, M. Yoshida, A. Tsugeno: "Solvolysis of 2-Methylene Bridgehead Derivatives: A Model for Gradual Variation of pi-Conjugation in Carbocation." Journal of Organic Chemistry. Vol.57. 280-289 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toshi Nagata: "Synthesis and Characterization of Doubly-Strapped porphyrins." Bulletin of the Chemical Society of Japan. Vol.65. 385-391 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I. K. Lednev, M. V. Aifimov Y. Kuriyama, T. Arai, H. Sakuragi, K. Tokumaru: "Photosensitized cis-trans Isomerization of Stilbene via Cation Radical Mechanism in Micellar Solution." Journal of Photochemistry & Photobiology A: Chem.Vol.63. 201-209 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] G. Yamamoto, H. Higuchi, H. Yamamoto, J. Oijma: "1H and 13C Spectral Behavior and Isomerism in bisdehydro[15] annulenones." Bulletin of the Chemical Society of Japan. Vol.65. 2388-2394 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] W. Ando, F. Hoji, S. Sekigawa, N. Nakajima, T. Shimizu: "First Isolation of Six-Membered Cyclic Acetylene: Synthesis and Reaction of Tetrasilacyclohexynes." Organometallics. Vol.11. 1009-1220 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Ohkata, M. Ohnishi, K. Yoshinaga, K. Akiba J. C. Rongipne, J. C. MArtin: "Apical and Equatorial Methoxy Ligands on Sulfuranes: Effect on Rates of Pyridine Methylation" Journal of American Chemical Society. Vol.113. 9270-9276 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Matano, M. Kinoshita H. Suzuki: "Synthesis and Reactions of Some Crowded Triorganyl Bismuthines." Bulletin of the Chemical Society of Japan. Vol.65. 3504-3511 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Takemura, T. Shinmyozu, T. Inazu: "Syntheses and Properties of Highly Symmetrical Cage Compounds: Pyridine Analogues of Hexa-m-xylylenetetramine" Journal of American Chemical Society. Vol.113. 1323-1331 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A. Ohno, M. Okamura, T. Kashiwagi, Y. Mikata, N. Yamazaki: "Stereospecific Electrochemical Oxidation of NAD(P)H Analogs Mediated by Radical Cation of Anilines." Chemistry Letters. Vol.1992. 1247-1250

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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