1990 Fiscal Year Annual Research Report

生物進化の分子集団遺伝学的研究

Research Project

Project/Area Number	02304001
Research Institution	Kyushu University
Principal Investigator	山崎常行九州大学, 理学部, 助教授 (10108649)
Co-Investigator(Kenkyū-buntansha)	石和貞夫お茶の水女子大学, 理学部, 教授 (20017205) 戸張よし子東京都立大学, 理学部, 教授 (20087125) 高畑尚之国立遺伝学研究所, 集団遺伝系, 助教授 (30124217) 太田朋子国立遺伝学研究所, 集団遺伝系, 教授 (80000256) 木村資生国立遺伝学研究所, 名誉教授 (20000226)
Keywords	分子進化 / 集団遺伝学 / DNA多型 / トランスポゾン / ミトコンドリアDNA / 多重遺伝子 / MHC遺伝子
Research Abstract	〈実験的研究〉 (1)ショウジョウバエを用いてAmy、リボソ-ム、Xdh、Adh、Gpdn遺伝子座及びその近傍の分子多型の調査を行った。(山崎・戸張・日下部・高野)。アミラ-ゼおよびGpdn遺伝子には重複多型が存在し、重複遺伝子間に共調進化が起こっている証拠を得た。小麦のRDCL遺伝子についても分子多型の解析を行った。(宮下)。 (2)形質転換法を用いてアミラ-ゼ遺伝子の上流約1000kbにわたって調節に重要な領域が存在することを明らかにした。またグルコ-ルコ-スリプレッションに関する研究も行った(山崎)。 (3)ショウジョウバエトランスポゾンの集団における動態を特にP因子の活性と遺伝的荷重との関連において調査した(原田)。 (4)イエバエの性決定機構の分子機構とその適応進化についての研究を行った(広吉)。 (5)キイロショウジョウバエの近縁種3種についてミトコンドリアDNAの変異を調査し、これから種間の類縁関係を推定した(石和)。〈理論的研究〉 (1)新たに解析した遺伝子をもとに分子進化の中立説の妥当性について検証を行った(木村)。 (2)DNA多型の保育に関する統計的検証法を調査した(田嶋)。 (3)弱有害遺伝子の種内多型を進化速度の解析を行った。また量的形質における瓶首効果の解析を行った(舘田)。 (4)多重遺伝子族の多型と自然淘汰に関して、コンピュ-タシュミレ-ションを行って重複遺伝子の進化理論を研究した(太田)。 (5)哺乳類MHC遺伝子の多型の維持機構と進化について解析した。(高畑)

Research Products
(7 results)

All Other

All Publications (7 results)

[Publications] Mukai,T.,Harada,Kusakabe and T.Yamazaki: "Estimation of Spontaneous mutation rates at enzyme loci in <Drosophila>___ー <melanogaster>___ー" Proc.Natl.Acad.Sci.USA. 66. 29-32 (1990)
[Publications] Tanaka,T.,and T.Yamazaki: "Fitness and its components in <Drosophila>___ー <melanogaster>___ー." Jpn.J.Genet.65. 417-426 (1990)
[Publications] Nitasaka,E.and T.Yamazaki: "A novel eye morphology induced by P element in somatic tissue of <Drosophila>___ー <melanogaster.>___ー" Molecular and General Genetics. (1991)
[Publications] Nitasaka,E.,and T.Yamazaki: "The relationship between DNA structural variations and activities of P elements in typical P and Q strains of <Drosophila>___ー <melanogaster>___ー." Genet.Res.Camb.(1991)
[Publications] Nitasaka,E.,M.M.Green,and T.Yamazaki: "The molecular analysis of brown eye color mutations isolated from geographically discrete populations of <Drosophila>___ー <melanogaster>___ー." Proc.Natl.Acad.Sci.USA. (1991)
[Publications] Yamazaki,T.: "POPULATION BlOLOGY OF GENES AND MOLECULES(Nucleotide polymorphism and evolution of multigine families in Drosophila.)" ed.by N.Takahata and J.F.Crow(Baifukan), 151-167 (1990)
[Publications] Nitasaka,E.,and T.Yamazaki: "NEW ASPECT OF GENETICS IN MOLECULAR EVOLUTION(Genetic variation and regulation of P__ー elements in <Drosophila>___ー <melanogaster>___ー.)" ed.by Kimura,M.and T.Takahata(Japan Sci.Press), 1-14 (1990)

1990 Fiscal Year Annual Research Report

生物進化の分子集団遺伝学的研究

Principal Investigator

山崎常行九州大学, 理学部, 助教授 (10108649)

Research Products

[Publications] Mukai,T.,Harada,Kusakabe and T.Yamazaki: "Estimation of Spontaneous mutation rates at enzyme loci in <Drosophila>_ー <melanogaster>_ー" Proc.Natl.Acad.Sci.USA. 66. 29-32 (1990)

[Publications] Tanaka,T.,and T.Yamazaki: "Fitness and its components in <Drosophila>_ー <melanogaster>_ー." Jpn.J.Genet.65. 417-426 (1990)

[Publications] Nitasaka,E.and T.Yamazaki: "A novel eye morphology induced by P element in somatic tissue of <Drosophila>_ー <melanogaster.>_ー" Molecular and General Genetics. (1991)

[Publications] Nitasaka,E.,and T.Yamazaki: "The relationship between DNA structural variations and activities of P elements in typical P and Q strains of <Drosophila>_ー <melanogaster>_ー." Genet.Res.Camb.(1991)

[Publications] Nitasaka,E.,M.M.Green,and T.Yamazaki: "The molecular analysis of brown eye color mutations isolated from geographically discrete populations of <Drosophila>_ー <melanogaster>_ー." Proc.Natl.Acad.Sci.USA. (1991)

[Publications] Yamazaki,T.: "POPULATION BlOLOGY OF GENES AND MOLECULES(Nucleotide polymorphism and evolution of multigine families in Drosophila.)" ed.by N.Takahata and J.F.Crow(Baifukan), 151-167 (1990)

[Publications] Nitasaka,E.,and T.Yamazaki: "NEW ASPECT OF GENETICS IN MOLECULAR EVOLUTION(Genetic variation and regulation of Pー elements in <Drosophila>_ー <melanogaster>___ー.)" ed.by Kimura,M.and T.Takahata(Japan Sci.Press), 1-14 (1990)

1990 Fiscal Year Annual Research Report

生物進化の分子集団遺伝学的研究

Principal Investigator

山崎 常行 九州大学, 理学部, 助教授 (10108649)

Research Products

[Publications] Mukai,T.,Harada,Kusakabe and T.Yamazaki: "Estimation of Spontaneous mutation rates at enzyme loci in <Drosophila>___ー <melanogaster>___ー" Proc.Natl.Acad.Sci.USA. 66. 29-32 (1990)

[Publications] Tanaka,T.,and T.Yamazaki: "Fitness and its components in <Drosophila>___ー <melanogaster>___ー." Jpn.J.Genet.65. 417-426 (1990)

[Publications] Nitasaka,E.and T.Yamazaki: "A novel eye morphology induced by P element in somatic tissue of <Drosophila>___ー <melanogaster.>___ー" Molecular and General Genetics. (1991)

[Publications] Nitasaka,E.,and T.Yamazaki: "The relationship between DNA structural variations and activities of P elements in typical P and Q strains of <Drosophila>___ー <melanogaster>___ー." Genet.Res.Camb.(1991)

[Publications] Nitasaka,E.,M.M.Green,and T.Yamazaki: "The molecular analysis of brown eye color mutations isolated from geographically discrete populations of <Drosophila>___ー <melanogaster>___ー." Proc.Natl.Acad.Sci.USA. (1991)

[Publications] Yamazaki,T.: "POPULATION BlOLOGY OF GENES AND MOLECULES(Nucleotide polymorphism and evolution of multigine families in Drosophila.)" ed.by N.Takahata and J.F.Crow(Baifukan), 151-167 (1990)

[Publications] Nitasaka,E.,and T.Yamazaki: "NEW ASPECT OF GENETICS IN MOLECULAR EVOLUTION(Genetic variation and regulation of P__ー elements in <Drosophila>___ー <melanogaster>___ー.)" ed.by Kimura,M.and T.Takahata(Japan Sci.Press), 1-14 (1990)

山崎常行九州大学, 理学部, 助教授 (10108649)

[Publications] Mukai,T.,Harada,Kusakabe and T.Yamazaki: "Estimation of Spontaneous mutation rates at enzyme loci in <Drosophila>_ー <melanogaster>_ー" Proc.Natl.Acad.Sci.USA. 66. 29-32 (1990)

[Publications] Tanaka,T.,and T.Yamazaki: "Fitness and its components in <Drosophila>_ー <melanogaster>_ー." Jpn.J.Genet.65. 417-426 (1990)

[Publications] Nitasaka,E.and T.Yamazaki: "A novel eye morphology induced by P element in somatic tissue of <Drosophila>_ー <melanogaster.>_ー" Molecular and General Genetics. (1991)

[Publications] Nitasaka,E.,and T.Yamazaki: "The relationship between DNA structural variations and activities of P elements in typical P and Q strains of <Drosophila>_ー <melanogaster>_ー." Genet.Res.Camb.(1991)

[Publications] Nitasaka,E.,M.M.Green,and T.Yamazaki: "The molecular analysis of brown eye color mutations isolated from geographically discrete populations of <Drosophila>_ー <melanogaster>_ー." Proc.Natl.Acad.Sci.USA. (1991)

[Publications] Nitasaka,E.,and T.Yamazaki: "NEW ASPECT OF GENETICS IN MOLECULAR EVOLUTION(Genetic variation and regulation of Pー elements in <Drosophila>_ー <melanogaster>___ー.)" ed.by Kimura,M.and T.Takahata(Japan Sci.Press), 1-14 (1990)