1992 Fiscal Year Annual Research Report

生物進化の分子集団遺伝学的研究

Research Project

Project/Area Number	02304001
Research Institution	KYUSHU UNIVERSITY
Principal Investigator	山崎常行九州大学, 理学部, 教授 (10108649)
Co-Investigator(Kenkyū-buntansha)	石和貞男お茶の水女子大学, 理学部, 教授 (20017205) 戸張よし子東京都立大学, 理学部, 教授 (20087125) 高畑尚之総合研究大学院大学, 生命科学研究科, 教授 (30124217) 太田朋子国立遺伝学研究所, 集団遺伝系, 教授 (80000256) 木村資生国立遺伝学研究所, 集団遺伝系, 名誉教授 (20000226)
Keywords	分子集団遺伝学 / 進化 / 中立説 / 適応進化 / 多重遺伝子族 / ショウジョウバエ
Research Abstract	実験研究:(山崎)アミラーゼアイソザイムの塩基配列の決定を行ない、アミラーゼ遺伝子は共調進化によって進化しており、種分化には適応進化が働いている事が明かとなった。(戸張)アナナスショウジョウバエ種群5種を用いてrDNA非転写領域内のsite variationを調べ、rDNA変異の種内、集団内での固定、均一化がmtDNAよりも早い事が分かった。(広吉)イエバエの性決定因子MおよびFについてPCR法を用いてクローニングを試みた。(石和)melanogaster complex4種についてそれぞれ複数系統per遺伝子の一部の塩基配列を決定し、種特異的求愛歌リズムに関するアミノ酸座位を3箇所以内に絞った。(原田)キイロショウジョウバエの自然突熱変異率を7つの酵素遺伝子座について推定し、移動度の突熱変異率として7.06x10^<-7>/世代/遺伝子座という値を得た。(日下部)キイロショウジョウバエの近縁種にGPDH遺伝子座における重複多型が殆ど存在しない事を確認した。(高野)キイロショウジョウバエ6系統とオナジショウジョウバエ1系統の5.3kbの領域について塩基配列の決定を完了した。理論研究:(木村)分子レベルでのと表現型進化の橋渡しを行なう試みとして、大進化四段階説を提唱した。(太田)DNAデータ解析による理論の検証を行ない、プロテアーゼとそのインヒビターの活性部位の変異性が遺伝子変換によってもたらされることを示した。(高畑)脊椎動物の免疫系で、自己・非自己を識別している分子の進化学的研究を行なった。(田嶋)DNAレベルの集団内変異に関する研究・分子系統樹作成に関する統計的研究を行った。(舘田)集団の地理的構造や交配様式がヘテロザイゴシティや連鎖不平衡に与える影響の研究・散在うる反復配列を用いた集団構造の推定法に関する考察。(飯塚)2遺伝子座2対立遺伝子モデルにおける固定確率および平均固定待ち時間を拡散方程式を使って研究した。

Research Products
(20 results)

All Other

All Publications (20 results)

[Publications] Nitasaka,E.and Yamazaki,T.: "The molecular analysis of brown eye color mutations isolated from geographically discrete populations of Drosophila melanogaster." Proc.Natl.Acad.Sci.USA. (1993)
[Publications] Nitasaka,E.and Yamazaki,T.: "The relation ship between DNA structural variations and activities of P elements in P and Q strains of Drosophila melanogaster." Genetical Research. (1993)
[Publications] Ohta,T.: "Theoretical study of near neutrality.II.Effect of subdivided population structure with local extinction and recolonization." Genetics. 130. 917-923 (1992)
[Publications] Ohta,T.: "The meaning of natural selection revisited at the molecular level." Trends in Ecology and Evolution. 7. 311-312 (1992)
[Publications] Takahata,N.,Satta,Y.and Klein,J.: "Polymorphism and balancing selection at major histocompatibility complex loci." Genetics. 130. 925-938 (1992)
[Publications] Morita,T.,Takahata,N.et.al.: "Recent and World-wide Introgression to Mus musculus." Proc.Natl.Acad.Sci.USA. 89. 6851-6855 (1992)
[Publications] Matsubayashi,H.,Tobari,Y.N.etal.: "Cytological mapping of On mutants of Drosophila ananassae." Jpn.J.Genet.67. 259-264 (1992)
[Publications] Kaneko,M.,Satta,Y.,Matsuura,E.T.and Chigusa,S.: "Evolution of the mitochondrial ATP ase 6 gene in Drosophila.:Unusually high level of polymorphism in D.melanogaster." Genetical Research. (1993)
[Publications] Harada,K.,Kusakabe,S.and Mukai,T.: "Comparative study of P element activity in two natural populations of Drosophila melanogaster." Jpn.J.Genet.66. 725-737 (1991)
[Publications] Koga,A.,Harada,K.,Kusakabe,S.and Mukai,T.: "Spontaneous mutations affecting glycerol-3-phosphate dehydrogenase enzyme activity in Drosophila melanogaster." Jpn.J.Genet.67. 125-132 (1992)
[Publications] Tachida,H.and Iizuka,M.: "Persistence of repeated sequences that evolve by replication slippage." Genetics.131. 471-478 (1992)
[Publications] Maruyama,K.and Tachida,H.: "Genetic variability and geographical structure in partially selfing populations." Jpn.J.Genet.67. 39-51 (1992)
[Publications] Tajima,F.: "Statistical method for estimating the standard errors of branch lengths in a phylogenetics tree reconstructed without assuming equal rates of nucleotide substitution among different lineages." Molecular Biology and Evolution. 9. 168-181 (1992)
[Publications] Tajima,F.: "Statistical method for estimating the effective population size in Pacific salmon." J.of Heredity. 83. 309-311 (1992)
[Publications] Kaplan,N.L.,Hudson,R.R.and Iizuka,M.: "The coalescent process in models with selection,recombination and geographic subdivision." Genetical Research Camb.57. 83-91 (1991)
[Publications] Tachida,H.and Iizuka,M.: "Fixation probability in spatially changing environments." Genetical Research Camb.58. 243-251 (1991)
[Publications] Takahata,N.: "The Proceedings of the 17th Taniguchi International Symposium on Biophsics." Japan Scientific Society Press., (1992)
[Publications] Takahata,N.: "Molecular Paleopulation Biology." Japan Scientific Society Press., (1992)
[Publications] Tobari,Y.N.: "Drosophila ananassaeーGenetical and Biological Aspects" Japan Scientific Societics Press., (1993)
[Publications] 舘田英典,向井輝美: "実験集団遺伝子と進化「講座進化6,分子から見た進化」" 東京大学出版会, (1992)

1992 Fiscal Year Annual Research Report

生物進化の分子集団遺伝学的研究

Principal Investigator

山崎 常行 九州大学, 理学部, 教授 (10108649)

Research Products

[Publications] Nitasaka,E.and Yamazaki,T.: "The molecular analysis of brown eye color mutations isolated from geographically discrete populations of Drosophila melanogaster." Proc.Natl.Acad.Sci.USA. (1993)

[Publications] Nitasaka,E.and Yamazaki,T.: "The relation ship between DNA structural variations and activities of P elements in P and Q strains of Drosophila melanogaster." Genetical Research. (1993)

[Publications] Ohta,T.: "Theoretical study of near neutrality.II.Effect of subdivided population structure with local extinction and recolonization." Genetics. 130. 917-923 (1992)

[Publications] Ohta,T.: "The meaning of natural selection revisited at the molecular level." Trends in Ecology and Evolution. 7. 311-312 (1992)

[Publications] Takahata,N.,Satta,Y.and Klein,J.: "Polymorphism and balancing selection at major histocompatibility complex loci." Genetics. 130. 925-938 (1992)

[Publications] Morita,T.,Takahata,N.et.al.: "Recent and World-wide Introgression to Mus musculus." Proc.Natl.Acad.Sci.USA. 89. 6851-6855 (1992)

[Publications] Matsubayashi,H.,Tobari,Y.N.etal.: "Cytological mapping of On mutants of Drosophila ananassae." Jpn.J.Genet.67. 259-264 (1992)

[Publications] Kaneko,M.,Satta,Y.,Matsuura,E.T.and Chigusa,S.: "Evolution of the mitochondrial ATP ase 6 gene in Drosophila.:Unusually high level of polymorphism in D.melanogaster." Genetical Research. (1993)

[Publications] Harada,K.,Kusakabe,S.and Mukai,T.: "Comparative study of P element activity in two natural populations of Drosophila melanogaster." Jpn.J.Genet.66. 725-737 (1991)

[Publications] Koga,A.,Harada,K.,Kusakabe,S.and Mukai,T.: "Spontaneous mutations affecting glycerol-3-phosphate dehydrogenase enzyme activity in Drosophila melanogaster." Jpn.J.Genet.67. 125-132 (1992)

[Publications] Tachida,H.and Iizuka,M.: "Persistence of repeated sequences that evolve by replication slippage." Genetics.131. 471-478 (1992)

[Publications] Maruyama,K.and Tachida,H.: "Genetic variability and geographical structure in partially selfing populations." Jpn.J.Genet.67. 39-51 (1992)

[Publications] Tajima,F.: "Statistical method for estimating the standard errors of branch lengths in a phylogenetics tree reconstructed without assuming equal rates of nucleotide substitution among different lineages." Molecular Biology and Evolution. 9. 168-181 (1992)

[Publications] Tajima,F.: "Statistical method for estimating the effective population size in Pacific salmon." J.of Heredity. 83. 309-311 (1992)

[Publications] Kaplan,N.L.,Hudson,R.R.and Iizuka,M.: "The coalescent process in models with selection,recombination and geographic subdivision." Genetical Research Camb.57. 83-91 (1991)

[Publications] Tachida,H.and Iizuka,M.: "Fixation probability in spatially changing environments." Genetical Research Camb.58. 243-251 (1991)

[Publications] Takahata,N.: "The Proceedings of the 17th Taniguchi International Symposium on Biophsics." Japan Scientific Society Press., (1992)

[Publications] Takahata,N.: "Molecular Paleopulation Biology." Japan Scientific Society Press., (1992)

[Publications] Tobari,Y.N.: "Drosophila ananassaeーGenetical and Biological Aspects" Japan Scientific Societics Press., (1993)

[Publications] 舘田 英典,向井 輝美: "実験集団遺伝子と進化「講座進化6,分子から見た進化」" 東京大学出版会, (1992)

山崎常行九州大学, 理学部, 教授 (10108649)

[Publications] 舘田英典,向井輝美: "実験集団遺伝子と進化「講座進化6,分子から見た進化」" 東京大学出版会, (1992)