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1991 Fiscal Year Final Research Report Summary

Integrative analysis of physiological adaption to environmental stress.

Research Project

Project/Area Number 02304032
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

MORIMOTO T.  Kyoto Pref. Univ. of Med., Dept. Physiol., Professor, 医学部, 教授 (30079694)

Co-Investigator(Kenkyū-buntansha) KOSAKA M.  Inst. of Trop. Med., Nagasaki Uni., Professor, 熱帯医学研究所, 教授 (30079983)
永坂 鉄夫  金沢大学, 医学部, 教授 (80023646)
広重 力  北海道大学, 医学部, 教授 (50000914)
IRIKI M.  Yamanashi Med. College, Professor, 医学部, 教授 (90072967)
村上 悳  山口大学, 医学部, 教授 (90040518)
KAWATA M.  Kyoto Pref. Univ. Med., Professor (60112512)
KUROSHIMA A.  Asahikawa Med. College, Professor (90002774)
ONO T.  Toyama Med. Pharm. Univ., Professor (50019577)
Project Period (FY) 1990 – 1991
KeywordsEnvironment / Adaptation / Body temperature / Circulation / Body fluid / Immune response / Circadian rhythm / Behavior
Research Abstract

The aim of this Cooperative research was to analyze the adaptive mechanism of living organism to environmental stresses from different aspects, and to obtain the integrative view of physiological adaptation. As the regulatory responses, the adaptive mechanisms were studied from body temperature regulation, circulatory adjustments, body fluid regulation, and metabolism using from single cell to whole body and behavior. As the controlling factors, involvements of nervous system, endocrine system and the relationship with immune system were also covered.
Themes studied include the relationship between total peripheral resistance and central venous pressure, regulation of skin blood flow during local heating, the relationship between skin blood flow and sympathetic nervous activity, fever and the regional response of sympathetic nervous activity, the effect of gangliocides on the thermogenesis of brown adipose tissue, the effects of peptides and cytokines on the regulation of body fluid and circulatory functions, the effects of LPS, IL-1 and heat stress on the activity of macrophage, the role of catecholamine in CNS on circadian rhythm, the role of limbic system on space recognition, and the morphological changes of nerve cell due to ECF changes.
Scientific meetings were held twice during the research period, and based on the presentations of these research works, lively discussions were made on the integrative view of these adaptive responses to environmental stress, interactions of these responses, the hierarchic structure of adaptive functions, and the control mechanism of these adaptive changes.
The discussion was very stimulating to each member of the group, and will have feedback effects on their work and also to the environmental physiologists through their published works.

  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] 入来 正躬: "自律神経系の地域性反応" 神経研究の進歩. 33. 196-206 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Ono et al.: "Role of Monkey hippocampus in recognition of food and nonfood." Brain Res.Bull.27. 457-461 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Kawata et al.: "Localization and regulation of mRNAs in the nervous tissue as revealed by in situ hybridization." Comp.Biochem.Physiol.98C. 41-50 (1991)

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      「研究成果報告書概要(和文)」より
  • [Publications] A.Kuroshima et al.: "Cold-induced changes in brown adipose tissue ganglioside levels." Jpn.J.Physiol.40. 57-64 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Kosaka et al.: "Study on the mechanism of thermal acclimatization in pika(whistle rabbit)." Jpn.J.Trop.Med.Hyg.19. 90-91 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Shiraki et al.: "Sympathetic nerve activity and renal responses during continuous negative pressure breathing in humans." Am.J.Physiol.261. R276-R282 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Hiroshige et al.: "SCN-independent circadian oscillations in the rat." Brain Res.Bull.27. 441-445 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Hori: "An update on thermosensitive neurons in the brain:from cellular biology the thermal and non-thermal homeostatic functions." Jpn.J.Physiol.41. 1-22 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Nagasaka et al.: "Effect of heat acclimation on diurnal changes in body temperature and locomotor activity in rats." J.Physiol.433. 59-71 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Murakami et al.: "Possible involvement of prostaglandins in psychological stress-induced responses in rats." J.Physiol.443. 421-429 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Morimoto: "Thermoregulation and body fluids:role of blood volume and central venous pressure." Jpn.J.Physiol.40. 165-179 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yamashita et al.: "Effects of centrally administered atrial natriuretic polypeptide on sympathetic nerve activity and blood flow to the kidney in conscious rats." Neurosci.Lett.116. 123-129 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] M.Iriki et al.: "Thermoregulation:Research and Clinical Applications" Kager, 91-94 (1989)

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      「研究成果報告書概要(和文)」より
  • [Publications] 小野 武年: "脳と思考" 紀伊国屋書店, 243-313 (1991)

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      「研究成果報告書概要(和文)」より
  • [Publications] T.Hori et al.: "New Trends in Autonomic Nervous System Research" Elsevier Sci.Publ., 47-50 (1991)

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      「研究成果報告書概要(和文)」より
  • [Publications] K.Honma et al.: "Endocrine Chronobiology" Hokkaido University Press, 42-50 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T. Saigusa, and M. Iriki: "The participation of IL-1and TNF in the responses of the sympathetic nervous system during LPS-induced fever." Pflugers Arch. 416. 225-229 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Ono et al.: "Place recognition responses of neurons in monkey hippocampus." Neurosci. Lett.121. 194-198 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Kawata et al.: "In situ hybridization histochemistry with oligodeoxynucleotide probe as a tool for the detection of neuropeptide mRNAs." Acta histochem.cytochem. 23 :. 307-325 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A. Kuroshima et al.: "Cold- and noradrenaline induced changes in ganglioside GM3 levels of rat brown adipose tissue." J. Therm Physiol.16. 37-39 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Kosaka et al.: "Study on the mechanism of thermal acclimatization in the pika (whistle rabbit)." Jpn. J. Trop. Med. Hyg. 19. 90-91 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Shiraki et al.: "Sympathetic nerve activity and renal responses during continuous negative pressure breathing in humans." Am. J. Physiol.261. R276-282 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Nagasaka et al.: "Effect of heat acclimation on diurnal changes in body temperature and locomotor activity in rats." J. Physiol.433. 59-71 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Hiroshige et al.: "SCN-independent circadian oscillations in the rat." Brain Res. Bull.27. 441-445 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Hori et al.: "Immune cytokines and regulation of body temperature, food intake and cellular immunity." Brain Res. Bull.27. 309-313 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Hori: "An update on thermosensitive neurons in the brain : from cellular biology the thermal and non-thermal homeostatic functions." Jpn. J. Physiol.41. 1-22 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Murakami et al.: "Possible involvement of prostaglandins in psychological stress-induced responses in rats." J. Physiol.443. 421-429 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Yamashita et al.: "Inhibition by brain natriuretic peptide of vasopressin neurons in the supraoptic nucleus and neurons in the region of the anterioventral third ventricle in rat hypothalamic slice preparations." J. Neuroend.3. 45-49 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Morimoto: "Thermoregulation and body fluids : role of blood volume and central venous pressure." Jpn. J. Physiol.40. 165-179 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Morimoto et al.: "Vascular viscoelasticity of perfused rat hindquarter." Am. J. Physiol.260. H1834-1840 (1991)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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