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1992 Fiscal Year Final Research Report Summary

Molecular Mechanism of Defense against Stress and Metabolic Regulation by Glutathione and Its Metabolites

Research Project

Project/Area Number 02304035
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionKYOTO UNIVERSITY (1992)
Hirosaki University (1990-1991)

Principal Investigator

KUMAGAI Hidehiko  Kyoto University, Faculty of Agriculture, Professor, 農学部, 教授 (70027192)

Co-Investigator(Kenkyū-buntansha) HIGASHI Taneaki  Kohshiene University, School of Nutrition, Professor, 栄養学部, 教授 (50028304)
WATABE Tadashi  Tokyo College of Pharmacy, Professor, 教授 (00057316)
TANIGUCHI Naoyuki  Osaka University Medical School, Professor, 医学部, 教授 (90002188)
KATUNUMA Nobuhiko  The Tokushima Bunri University, Institute for Life Sciences, Professor, 健康科学研究所, 教授 (50035375)
MURAMATSU Masami  Saitama Medical School, Professor, 教授 (10035454)
Project Period (FY) 1990 – 1992
KeywordsGlutathione / Glutathione S-transferase / Cysteine protease inhibitor / Lipid hydroperoxide / Cell survival / Oxidative stress / Oxido-reduction / Transport system
Research Abstract

(1) A cDNA for glutathione S-transferase (GST) of the yeast and gene for Escherichia coli gamma-glutamyl transpeptidase (gamma-GTP) have been cloned and their sequences have been determined.
(2) Cis-elements involved in GST-P gene expression and their transcription factors have been identified.
(3) GST-P has been shown to be inactivated by SH-reagents and hydrogen peroxide. The 47th cysteine residue has been identified as the target amino acid in its inactivation.
(4) New GST forms active toward hydroxymethylarene sulfate have been purified from rat livers and these forms are shown to constitute the fourth class of GST.
(5) Expression of gamma-GTP in LEC rat liver has been shown to be dependent on hypomethylation of DNAs. Arg-107 and Blu-108 have been identified as residues constituting active sites of human gamma-GTP.
(6) A cDNA for human plasma glutathione peroxidase has been cloned and its sequence has been determined. This enzyme is active toward phospholipid hydroperoxides.
(7) Cystatin … More alpha is phosphorylated while cystatin beta forms mixed disulfide with glutathione to lose the inhibitory activity. These post-translational modifications are suggested to play an important role during the intracellular translocation of these cystatins.
(8) A rat strain resistant to hepatocarcinogenesis by chemical carcinogens has been established. This strain has exhibited a different expression pattern in drug-metabolizing enzymes including GST and alcohol dehydrogenase from the control strain.
(9) In the tranport of GSH between the liver and kidney, GSH in the blood vessels plays an important role in regulation of blood pressure.
(10) In human leukemia K562 cells cis-diamminedichloroplatinum(II) is conjugated to glutathione and the complex is transported by GS-X conjugate-dependent ATPase, a transporter for GSSG or GS-X conjugates.
(11) A cystine transporter plays a key role to maintain GSH level in macrophages or endothelial cells, and this transporter activity is induced under stress conditions. Less

  • Research Products

    (106 results)

All Other

All Publications (106 results)

  • [Publications] Tamaki Hisanori: "Glutathione S-transferase in yeast:induction of mRNA,cDNA cloning and expression in Escherichia coli." Biochemical and Biophysical Research Communications. 172. 669-675 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamaki Hisanori: "Detoxification metabolism of o-dinitrobenzene by yeast Issatchenkia orientalis" Agricultural and Biological Chemistry. 55. 951-956 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hashimoto Wataru: "Escherichia coli γ-glutamyltranspeptidase mutants deficient in processing to subunits" Biochemical and Biophysical Research Communications. 189. 173-178 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Imagawa Masayoshi: "Silencer binding proteins function on multiple ciselements in the glutathione transferase P gene" Nucleic Acids Research. 19. 5-10 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Diccianni,Mitchell B.: "The dyad palindromic glutathione transferase P enhancer binds multiple factors including AP1" Nucleic Acids Research. 20. 5153-5158 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morimura Shigeru: "Trans-activation of glutathione transferase P gene during chemical hepatocarcinogenesis of the rat" Proceedings of National Academy of Science USA. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiratsuka Akira: "A new class of rat glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters as metabolites of carcinogenic arylmethanols" Journal of Biological Chemistry. 265. 11973-11981 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogura Kenichiro: "cDNA cloning of the hydroxysteroid sulfotransferase STa sharing a strong homology in amino acid sequence with the senescence marker protein SMP-2 in rat livers" Biochemical and Biophysical Research Communications. 166. 1494-1500 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogura Kenichiro: "Molecular cloning and amino acid sequencing of rat liver class theta glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters of carcinogenic arylmethanols" Biochemical and Biophysical Research Communications. 181. 1294-1300 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hammad,Hanaa: "Lipid peroxidation in the liver of carcinogenresistant rats" Biochimica et Biophysica Acta. 1045. 99-106 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inoue Masayasu: "Expression of a hybrid Cu,Zn-type superoxide dismutase which has high affinity for haparin-like proteoglycans on vascular endothelial cells" Journal of Biological Chemistry. 266. 16409-16414 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakazono Koichi: "Does superoxide underlie the pathogenesis of essential hypertension?" Proceedings of Nationol Academy of Science USA. 88. 10045-10048 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi Masae: "Identification of hematoxylin-stainable protein in epidermal keratohyalin granules as phosphorylated cystatin alpha by protein kinase C" FEBS Letters. 287. 178-180 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohshita Takeyuki: "Incorporation and degradation by kidney lysosomes of cystatin α injected intravenously" European Journal of Biochemistry. 205. 347-353 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi Masae: "Phosphorylated cystatin alpha is a natural substrate of epidermal transglutaminase for formation of skin cornified envelope" FEBS Letters. 308. 79-82 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shiozawa Masahide: "Synthesis of human gamma-glutamyltranspeptidase (GGT) during the fetal development of liver" Gene. 87. 299-303 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohno Hideki: "Effects of exercise stress and cold stress on glutathione and γ-glutamyltransferase in rat liver" Biochimica et Biophysica Acta. 1033. 19-22 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikeda Yoshitaka: "Significance of Arg-107 and Glu-108 in the catalytic mechanism of human γ-glutamyltranspeptidase:indentification by site-directed mutagenesis" Journal of Biological Chemistry. 268. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kunitomo Ryuji: "Synthesis of a cytochrome c derivative with prolonged in vivo half life and determination of ascorbyl radicals in the circulation of the rat" Journal of Biological Chemistry. 267. 8732-8738 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tagami Seiichi: "Effect of insulin on impaired anti-oxidant activities in aortic endothelian cells from diabetic rabbits" Metabolism. 41. 1053-1058 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi Kazuhiko: "Primary structure of human plasma glutathione peroxidase deduced from cDNA sequences" Journal of Biochemistry. 108. 145-148 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akasaka Masami: "A human cDNA sequence for a novel glutatione peroxidase-related protein" Nucleic Acids Research. 18. 4619-4619 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi Kazuhiko: "Primary structure of human plasma glutathione peroxidase" Phosphorus,Sulfur and Silicon and the Related Elements. 67. 455-460 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Cho Yukie: "Uptake of glutamate and cystine in C-6 glioma cells and in cultured astrocytes" Journal of Neurochemistry. 55. 2091-2097 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishii Tetsuro: "Expression of the mouse macrophage cystine transporter in Xenopus laevis oocytes" Archives of Biochemistry and Biophysics. 289. 71-75 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miura Kenji: "Cystine uptake and glutathione level in endothelial cells exposed to oxidative stress" American Journal of Physiology. 262. C50-C58 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsuchida Shigeki: "Purification and characterization of glutatione transferases with an activity toward nitroglycerin from human aorta and heart" Journal of Biological Chemistry. 265. 7150-7157 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamai Katsuto: "Role of cysteine residues in the activity of rat glutathione transferase P (7-7):elucidation by oligonucleotide site-directed mutagenesis" Biochemical and Biophysical Research Communications. 179. 790-797 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsuchida Shigaki: "Glutathione transferases and cancer" Critical Reviews in Biochemistry and Molecular Biology. 27. 337-384 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shen,Hongxie: "Identification of cysteine residues involved in disulfide formation in the inactivation of glutathione transferase P-form by hydrogen peroxide" Archives of Biochemistry and Biophysics. 300. 137-141 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kumagai Hidehiko: "Frontiers and New Horizons in Amino Acid Research" Elsevier Science Publishers, 587-588 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki Hideyuki: "Frontiers and New Horizons in Amino Acid Research" Elsevier Science Publishers, 589-593 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Jain,Siresh K.: "The LEC Rat,a New Model for Hepatitis and Liver Cancer" Springer Verlag, 162-168 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tateishi Noriko: "Frontiers and New Horizons in Amino Acid Research" Elsevier, 443-446 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Muramatsu Masami: "Xenobiotics and Cancer" Taylor & Francis, 189-198 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugiyama Toshihiro: "The LEC Rat,a New Model for Hepatitis and Liver Cancer" Springer Verlag, 155-161 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato Kiyomi: "Glutathione S-Transferases and Drug Resistance" Taylor & Francis, 389-398 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato Kiyomi: "Biochemical and Molecular Aspects of Selected Cancers Volume 1" Academic Press, 177-226 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamaki, H., Kumagai, H., and Tochikura, T.: "Glutathione S-transferase in yeast: induction of mRNA, cDNA cloning and expression in Escherichia coli." Biochem. Biophys. Res. Commun.172. 669-675 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kumagai, H., Suzuki, H., Echigo, T., and Tochikura, T.: "Synthesis of gamma-glutamyl peptides by gamma-glutamyltranspeptidase from E. coli." Annals N. Y. Acad. Sci.613. 647-651 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamaki, H., Kumagai, H., Shimada, Y., Kashima, T., Obata, H., Kim, C.-S., Ueno, T., and Tochikura, T.: "Detoxification metabolism of o-dinitrobenzene by yeast Issatchenkia orientalis." Agric. Biol. Chem.55. 951-956 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamaki, H., Kumagai, H., and Tochikura, T.: "Nucleotide sequence of the yeast glutathione S-transferase Y-2 cDNA." Biochim. Biophys. Acta. 1089. 276-279 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Claudio, J. O., Suzuki, H., Kumagai, H., and Tochikura, T.: "Excretion and rapid purification of gamma-glutamyltranspeptidase from Escherichia coli K-12." J. Ferment. Bioengineer.72. 125-127 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hashimoto, W., Suzuki, H., Nohara, S., and Kumagai, H.: "Escherichia coli gamma-glutamyltranspeptidase mutants deficient in processing to subunits." Biochem. Biophys. Res. Commun.189. 173-178 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Imagawa, M., Osada, S., Okuda, A., and Muramatsu, M.: "Silencer binding proteins function on multiple cis-elements in the glutathione transferase P gene." Nucleic Acids Res.19. 5-10 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Imagawa, M., Miyamoto, A., Shirakawa, M., Hamada, H., and Muramatsu, M.: "Stringent integrity requirements for both transactivation and DNA-binding in a transactivator, Oct 3." Nucleic Acids Res.19. 4503-4508 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Imagawa, M., Osada, S., Koyama, Y., Suzuki, T., Hirom, P. C., Diccianni, M. B., Morimura, S., and Muramatsu, M.: "SF-B that binds to a negative element in glutathione transferase P gene is similar or identical to transactivator LAP/IL6-DBP." Biochem. Biophys. Res. Commun.179. 293-300 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Katoh, T., Ohmori, H., Murakami, T., Karasaki, Y., Higashi, K., and Muramatsu, M.: "Induction of glutathione-S-transferase and heat-shock proteins in rat liver after ethylene oxide exposure." Biochem. Pharmacol.42. 1247-1254 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakai, M., Muramatsu, M., and Nishi, S.: "Suppression of glutathione transferase P expression by glucocorticoid." Biochem. Biophys. Res. Commun.187. 976-983 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Diccianni, M. B., Imagawa, M., and Muramatsu, M.: "The dyad palindromic glutathione transferase P enhancer binds multiple factors including APl." Nucleic Acids Res.20. 5153-5158 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morimura, S., Okuda, A., Sakai, M., Imagawa, M., and Muramatsu, M.: "Analysis of glutathione transferase P gene regulation with liver cells in primary culture." Cell Growth & Differentiation. 3. 685-691 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morimura, S., Suzuki, T., Hochi, S., Yuki, A., Kimie, N., Kitagawa, T., Nagatsu, I., Imagawa, M., and Muramatsu, M.: "Transactivation of glutathione transferase P gene during chemical hepatocarcinogenesis of the rat." Proc. Natl. Acad. Sci. USA.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Musil, D., Zucic, D., Turk, D., Engh, R. A., Mayr, I., Huber, R., Popovic, T., Turk, V., Towatari, T., and Katunuma, N.: "The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity." EMBO J.10. 2321-2330 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi, M., Tezuka, T., Towatari, T., and Katunuma, N.: "Identification of hematoxylinstainable protein in epidermal keratohyalin granules as phosphorylated cystatin alpha by protein kinase C." FEBS Lett.287. 178-180 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohshita, T., Ike, Y., and Katunuma, N.: "Incorporation and degradation by kidney lysosomes of cystatin alpha injected intravenously." Eur. J. Biochem.205. 347-353 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi, M., Tezuka, T., and Katunuma, N.: "Phosphorylated cystatin alpha is a natural substrate of epidermal transglutaminase for formation of skin cornified envelope." FEBS Lett.308. 79-82 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shiozawa, M., Hiraoka, Y., Yasuda, K., Imamura, T., Sakamuro, D., Taniguchi, N., Yamazoe, M., and Yoshikawa, H.: "Synthesis of human gamma-glutamyl transpeptidase (GGT) during the fetal development of liver." Gene (Amst.). 87. 299-303 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohno, H., Gasa, S., Habara, Y., Kuroshima, A., Sato, Y., Miyazawa, N., and Taniguchi, N.: "Effects of exercise stress and cold stress on glutathione and gamma-glutamyltransferase in rat liver." Biochim. Biophys. Acta. 1033. 19-22 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, K., Sugiyama, T., Ookawara, T., Kurosawa, T., and Taniguchi, N.: "High sensitivity to 5-azacytidine in LEC rats, a strain with a metabolic predisposition to hepatitis and hepatoma: possible involvement of DNA methylation in the expression of cytochrome P-450 and gamma-glutamyltranspeptidase." Biochem. Int.23. 9-14 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugiyama, T., Matsunaga, M., Jain, S. K., Jain, S., Ikeda, Y., and Taniguchi, N.: "Enhancing effect of a choline-deficient diet on alterations of hepatic drug-metabolizing enzymes in hepatitis- and hepatoma- predisposed rats (LEC rats)." Jpn. J. Cancer Res.82. 390-396 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikeda, Y., Fujii, J., and Taniguchi, N.: "Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase: identification by site-directed mutagenesis." J. Biol. Chem.268. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiratsuka, A., Sebata, N., Kawashima, K., Okuda, H., Ogura, K., Watabe, T., Satoh, K., Hatayama, I., Tsuchida, S., Ishikawa, T., and Sato, K.: "A new class of rat glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters as metabolites of carcinogenic arylmethanols." J. Biol. Chem.265. 11973-11981 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogura, K., Sohtome, T., Sugiyama, A., Okuda, H.,Hiratsuka, A., and Watabe, T.: "Rat liver cytosolic hydroxysteroid sulfotransferase (sulfotransferase a) catalyzing the formation of reactive sulfate esters from carcinogenic polycyclic hydroxymethylarenes." Mol. Pharmacol.37. 848-854 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogura, K., Kajita, J., Narihata, H., Watabe, T., Ozawa, S., Nagata, K., Yamazoe, Y., and Kato, R.: "cDNA cloning of the hydroxysteroid sulfotransferase STa sharing a strong homology in amino acid sequence with the senescence marker protein SMP-2 in rat livers." Biochem. Biophys. Res. Commun.166. 1494-1500 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogura, K., Nishiyama, T., Okada, T., Kajita, J., Narihata, H., Hiratsuka, A., and Watabe, T.: "Molecular cloning and amino acid sequencing of rat liver class theta glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters of carcinogenic arylmethanols." Biochem. Biophys. Res. Commun.181. 1294-1300 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, M., Kojima, M., Okuda, H., Watabe, T., and Tada, M.: "DNA polymerase action blocked by adenine adducts induced by 5-hydroxymethylchrysene sulfate." Biochem. Int.25. 19-27 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hammad, H., Higashi, T., Tateishi, N., Hanetani, M., and Sakamoto, Y.: "Lipid peroxidation in the liver of carcinogenresistant rats." Biochim. Biophys. Acta. 1045. 99-106 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okajima, K., Inoue, M., Koga, S., Okabe, H., and Takatsuki, K.: "Plasma concentration of polymorphonuclear leukocyte elastase-alpha_1-proteinase inhibitor complex in patients with gastric ulcer." Clin. Chim. Acta. 189. 237-242 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirota, M., Inoue, M., Ando, Y., and Morino, Y.: "Inhibition of stress-induced gastric mucosal injury by a long acting superoxide dismutase that circulates bound to albumin." Arch. Biochem. Biophys.280. 269-273 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue, M., Watanave, N., Sasaki, J., Tanaka, Y., and Amachi, T.: "Inhibition of oxygen toxicity bytargeting superoxide dismutase to endothelial cell surface." FEBS Lett.269. 89-92 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ando, Y., Inoue, M., Araki, S., and Morino, Y.: "Inhibition of carrageenin-induced paw edema by a superoxide dismutase derivative that circulates bound to albumin." Biochim. Biophys. Acta. 1073. 374-379 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Obayashi, H., Koshi, S., Miyauchi, Y., and Inoue, M.: "Inhibition of posthaemorrhagic transfusion-induced gastric mucosal injury by a long acting superoxide dismutase derivative." Proc. Soc. Exp. Biol. Med.196. 164-169 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi, R., Edashige, K., Sato, E., Inoue, M., Matsuno, T., and Utsumi, K.: "Luminol chemiluminescence and reactive oxygen generation by activated neutrophiles." Arch. Biochem. Biophys.285. 325-330 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oyanagui, Y., Sato, S., and Inoue, M.: "Inhibition of carrageenan paw edema by superoxide dismutase that binds to heparan sulfate on vascular endothelial cells." Biochem. Pharmacol.42. 991-995 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue, M., Watanabe, N., Sasaki, J., Matsuno, K., Tanaka, Y., Hatanaka, H., and Amachi, T.: "Expression of a hybrid Cu,Zn-type superoxide dismutase which has high affinity for heparin-like proteoglycans on vascular endothelial cells." J. Biol. Chem.266. 16409-16414 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakazono, K., Watanabe, N., Matsuno, K., Sasaki, J., Sato, T., and Inoue, M.: "Does superoxide underlie the pathogenesis of essential hypertension?" Proc. Natl. Acad. Sci. USA. 88. 10045-10048 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawamoto, S., Miyauchi, Y., and Inoue, M.: "Mechanism of entero-hepatic injury caused by circulatory disturbance of hepatic vessels in the rat." Proc. Soc. Exp. Biol. Med.198. 629-635 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koshi, S., Obayashi, H., Miyauchi, Y., and Inoue, M.: "Inhibition of postischemic reperfusion injury of the small intestine by diamine oxidase." Biochim. Biophys. Acta. 1075. 231-236 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Neihoerster, M., Inoue, M., and Wendel, A.: "A link between extracellular reactive oxygen and endotoxin-induced release of tumour necrosis factor alpha in vivo." Biochem. Pharmacol.43. 1154-1158 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato, E., Kobuchi, H., Edashige, K., Takahashi, M., Yoshioka, T., Utsumi, K., and Inoue, M.: "Dynamic aspects of superoxide dismutase isoenzymes during the ovulation in the rat." FEBS Lett.303. 121-125 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kunitomo, R., Miyauchi, Y., and Inoue, M.: "Synthesis of a cytochrome c derivative with prolonged in vivo half life and determination of ascorbyl radicals in the circulation of the rat." J. Biol. Chem.267. 8732-8738 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Komatsu, H., Koo, A., Inoue, M. Guth, P., and Kaplowitz, N.: "Neutrophil accumulation in ischemic reperfusion liver: evidence for a role of superoxide free radicals." Am. J. Physiol.262. G669-G676 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koo, A., Komatsu, H., Inoue, M., Guth P., and Kaplowitz, N.: "Contribution of the non-reflow phenomenon to hepatic injury following ischemia-reperfusion: evidence for a role of superoxide anions and leukocyte adhesion in the microcirculation." Hepatology. 15. 507-514 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akimaru, K., Utsumi, T., Sato, E., Klostergaard, J., Inoue, M., and Utsumi, K.: "Role of tyrosyl phosphorylation in neutrophil priming by tumor necrosis factor-alpha and granulocyte colony stimulating factor." Arch. Biochem. Biophys.298. 703-709 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tagami, S., Kondo, T., Yoshida, K., Hirokawa, J., Othsuka, Y., and Kawakami, Y.: "Effect of insulin on impaired anti-oxidant activities in aortic endothelial cells from diabetic rabbits." Metabolism. 41. 1053-1058 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi, K., Yamamoto, Y., Akasaka, M., Kobayashi, C., Mizoguchi, J., and Koyama, J.: "Primary structure of human plasma glutathione peroxidase deduced from cDNA sequences." J. Biochem.108. 145-148 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akasaka, M., Mizoguchi, J., and Takahashi, K.: "A human cDNA sequence for a novel glutathione peroxidase-related protein." Nucleic Acids Res.18. 4619-4619 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi, K., Yamamoto, Y., Akasaka, M., Kobayashi, C., Mizoguchi, J., and Koyama, J.: "Primary structure of human plasma glutathione peroxidase." Phosphorus, Sulfur and Silicon and the Related Elements. 67. 455-460 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Cho, Y., and Bannai, S.: "Uptake of glutamate and cystine in C-6 glioma cells and in cultured astrocytes." J. Neurochem.55. 2091-2097 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Taketani, S., Sato, H., Yoshinaga, T., Tokunaga, R., Ishii, T., and Bannai, S.: "Induction in mouse peritoneal macrophages of 34 kDa stress protein and heme oxygenase by sulfhydryl-reactive agents." J. Biochem.108. 28-32 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Taketani, S., Kohno, H., Tokunaga, R., Ishii, T., and Bannai, S.: "Selenium antagonizes the induction of human heme oxygenase by arsenite and cadmium ions." Biochem. Int.23. 625-632 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Bannai, S., Sato, H., Ishii, T., and Taketani, S.: "Enhancement of glutathione levels in mouse peritoneal macrophages by sodium arsenite, cadmium chloride and glucose/glucose oxidase." Biochim. Biophys. Acta. 1092. 175-179 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishii, T., Nakayama, K., Sato, H., Miura, K., Yamada, M., Yamada, K., Sugita, Y., and Bannai, S.: "Expression of the mouse macrophage cystine transporter in Xenopus laevis oocytes." Arch. Biochem. Biophys.289. 71-75 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miura, K., Ishii, T., Sugita, Y., and Bannai, S.: "Cystine uptake and glutathione level in endothelial cells exposed to oxidative stress." Am. J. Physiol.262. C50-C58 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuchida, S., and Sato, K.: "Rat spleen glutathione transferases. A new acidic form belonging to the Alpha class." Biochem. J.266. 461-465 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuchida, S., Maki, T., and Sato, K.: "Purification and characterization of glutathione transferases with an activity toward nitroglycerin from human aorta and heart. Multiplicity of the human class Mu forms." J. Biol. Chem.265. 7150-7157 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata, T., Hatayama, I., Satoh, K., Tsuchida, S., and Sato, K.: "Activation of rat glutathione transferases in class Mu by active oxygen species." Biochem. Biophys. Res. Commun.171. 845-851 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Satoh, K., Hatayama, I., Tsuchida, S., and Sato, K.: "Biochemical characteristics of a preneoplastic marker enzyme glutathione S-transferase P-form (7-7)." Arch. Biochem. Biophys.285. 312-316 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shen, H., Tamai, K., Satoh, K., Hatayama, I., Tsuchida, S., and Sato, K.: "Modulation of class Pi glutathione transferase activity by sulfhydryl group modification." Arch. Biochem. Biophys.286. 178-182 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuroda, H., Sugimoto, T., Ueda, K., Tsuchida, S., Horii, Y., Inazawa, J., Sato, K., and Sawada, T.: "Different drug sensitivity in two neuroblastoma cell lines established from the same patient before and after chemotherapy." Int. J. Cancer. 47. 732-737 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hatayama, I., Yamada, Y., Tanaka, K., Ichihara, A., and Sato, K.: "Induction of glutathione S-transferase P-form in primary cultured rat hepatocytes by epidermal growth factor and insulin." Jpn. J. Cancer Res.82. 807-814 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamai, K., Shen, H., Tsuchida, S., Hatayama, I., Satoh, K., Yasui, A., Oikawa, A., and Sato, K.: "Role of cysteine residues in the activity of rat glutathione transferase P (7-7): elucidation by oligonucleotide site-directed mutagenesis." Biochem. Biophys. Res. Commun.179. 790-797 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuchida, S., and Sato, K.: "Glutathione transferases and cancer." Crit. Rev. Biochem. Mol. Biol.27. 337-384 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aoki, Y., Satoh, K., Sato, K., and Suzuki, K. T.: "Induction of glutathione S-transferase P-form in primary cultured rat liver parenchymal cells by co-planar polychlorinated biphenyl congeners." Biochem. J.281. 539-543 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shen, H., Tsuchida, S., Tamai, K., and Sato, K.: "Identification of cysteine residues involved in disulfide formation in the inactivation of glutathione transferase P-form by hydrogen peroxide." Arch. Biochem. Biophys.300. 137-141 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yokoyama, Y., Tsuchida, S., Hatayama, I., and Sato, K.: "Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase." Carcinogenesis. 14. (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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