• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1991 Fiscal Year Final Research Report Summary

El mice : Seizure mechanisms and their management

Research Project

Project/Area Number 02304045
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionOkayama University

Principal Investigator

MORI Akitane  Okayama Univ. Med. Sch., Professor, 医学部, 教授 (20028434)

Co-Investigator(Kenkyū-buntansha) MIZIKAWA Kiminao  Okayama Univ. Med. Sch., Assistant Professor, 医学部, 講師 (40137154)
SUZUKI Jiro  Toho Univ. Sch. of Med., Professor, 医学部, 教授 (10090408)
SUGAYA Eiichi  Kanagawa Dental Univ., Professor, 歯学部, 教授 (50084710)
YAMAGAMI Sakae  Osaka Univ. Med. Sch., Associate Professor, 医学部, 助教授 (20047004)
MITA Takashi  Univ. of Occupation and Environmental Health Sch. of Med., Professor, 医学部, 教授 (20076988)
Project Period (FY) 1990 – 1991
KeywordsEl*mice / Poly A^+ RNA / c-fos mRNA / Glutamic Aicd / Aspartic Acid / GABA / Tyrosine / serotonin
Research Abstract

All experimental results by our research group are as follows :
1. The amino acid metabolism and gene activity, including poly-A^+ RNA and sodium channel mRNA expression, were unusual at the early postnatal stage in the brain and liver.
2. The expression of c-fos RNA was observed just after convulsion in the brain of seizure experienced El mice.
3. Disturbances of neuronal growth, development and differentiation were observed. Excitatory state of neuronal membrane was detected without any convulsant in the primary curtured neuron.
4. Mechanisms for onset of secondary generalized seizures were studied in the hippocampal neurons.
5. Decreased cell numbers and dendrites, and also muscimol binding sites were observed in the hippocampal region.
6. Epileptogenic abnormalities in the excitatory neurotransmitter binding sites were recognized.
7. Disorders in the GABAergic, noradrenergic, and glutamateric receptors were found in the brain.
8. GABAergic and glutamatergic neuronal systems changed with growth, development or stimulations.
9. Abnormal release of excitatory and inhibitory neurotransmitters was observed in the cerebral and hippocampal slices.
10. Genetically and extraordinally higher level of kynurenine, lower level of dopamine, and other metabolic disorders, were found in the brain.
11. Decreased transport of Ca into blood from the bone was recognized. This decreased availability of Ca may result in a decrease of calmodulin dependent synthesis of amines, which leads to a lowered seizure threshold.
12. El mouse seizures were inhibited by baclofen, a GABA_B receptor agonist, and citalopram, an inhibitor for serotonin re-uptake.
13. El mouse strain has been controlled genetically and microbiologically to keep and to breed and also to be easy available to any epileptologists for further experiments.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Mori,Akitane: "Genetically higher level of guanine and guanosine in the brain of epileptic El mice." Med.Sci.Res.19. 445-446 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitani,Takashi: "Unusual biochemical development of genetically seizure-susceptible El mice." Develop.Brain Res.64. 27-35 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugaya,Eiichi: "Cellular physiology of epileptogenic phenomena and its application of therapy against intractable epilepsy." Comp.Biochem.Physiol.98C. 249-270 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoneda,Yukio: "Neurochemical aspects of the N-methyl-D-aspartate receptor complex." Neuroscience Res.10. 1-33 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murashima,Yoshiya: "Temporal and Spacial differences during development in GABAergic systems of the El mouce." Jpn.J.Psy.Neurol.45. (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki,Jiro: "Inhibition,propagation and generalization of paroxysmal discharges in an epileptic mutant animal." Jpn.J.Psy.Neurol.45. 271-274 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mori,Akitane: "International Perspectives on Self-Regulation and Health" Plenum Press, 11 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoneda,Yukio: "Neuroreceptor Mechanisms in Brain" Plenum Press, 20 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mori, Akitne: "Genetically higher level of guanine and guanosine in the brain of epileptic El mice." Med. Sci. Res.19. 445-446 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitani, Takashi: "Unusual biochemical development of genetically seizure-susceptible El mice." Develop. Brain Res.64. 27-35 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugaya, Eiichi: "Cellular physiology of epileptogenic phenomena and its application of therapy against intractable epilepsy" Comp. Biochem. Physiol.98C. 249-270 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoneda, Yukio: "Neurochemical aspects of the N-methyl-D-aspartate meceptor complex." Neuroscience Res.10. 1-33 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murashima, Yoshiya: "Temporal and spacial differences during development in GABAergic systems of the El mouse." Jpn. J. Psy. Neurol.45. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki Jiro: "Inhibition, propagation and generalization of paroxysmal discharges in an epileptic mutant animal." Jpn. J. Psy. Neurol.45. 271-274 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mori, Akitane: "International Perspectives on Self-Regulation and Health" Plenum Press. 11. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoneda, Yukio: "Neuroreceptor Mechanisms in Brain" Plenum Press. 20. (1991)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1993-03-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi