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1993 Fiscal Year Final Research Report Summary

Mechanism of Metal Sensitization in Dental Patients and Dental Health Professionals

Research Project

Project/Area Number 02404075
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 補綴理工系歯学
Research InstitutionTokyo Medical and Dental University

Principal Investigator

INOUE Masayuki  Tokyo Medical and Dental University, Faculty of Dentistry, Dept.of Pros.II, Associate Professor, 歯学部, 助教授 (10013872)

Co-Investigator(Kenkyū-buntansha) TABATA Tsuneo  Tokyo Medical and Dental University, Faculty of Dentistry, Dept.of Pros.II, Prof, 歯学部, 教授 (20013849)
Project Period (FY) 1990 – 1993
KeywordsMetal Allergy / Epidemiological Study / Intraoral Dental Metals / Minute Sample Analysis / X-ray Fluorescence Analysis
Research Abstract

There has been a notable increase in dermal and mucosal lesions due to various forms of metal allergens within our living environment. Number of such cases have been reported through mass media. Researcher and staff of dental field dealing with various types of dental alloys must have a right perspective and a thorough knowledge towards such disease. However, incidence rate nor mechanism of sensitization by dental alloys within an oral environment has not yet been revealed.
In this study, the subjects were dental patients who have metal restorations, dental staff such as dentist, dental technician, or dental hygienist, and individuals who never had metal restorations or had a little chance to contact metals in their daily lives. Birth place, residential area for the recent 5 years, past history of any allergies and their symptoms, patch test results, oral conditions, and relationship between the presence of intraoral metal restorations and the sensitization rate by these metals were investigated for these subjects.
An X-ray fluorescence spectroscope(XRFS) was used for the metal analysis in this study. Stability, detection limit, and the effects of different types of media towards the emitted X-ray were determined for the apparatus preceding its clinical application. The XRFS was proved to be capable of analyzing not only bulk metals, but also liquids, pastes, powders, leather goods, textiles, or those samples which require non-destructive analysis. Over 2500 samples collected from the intraoral metal restorations or living environments of the patients suspected as having metal allergies were analyzed to detect the metal allergens.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 松村光明: "歯冠修復用金属の評価法に関する研究第1報 浸潰試験における金属の変化の観察" 日本補綴歯科学会雑誌. 30(5). 1198-1209 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松村光明: "歯冠修復用金属の評価法に関する研究第2報 ラット皮下埋入試験と浸潰試験の関連性について" 日本補綴歯科学会雑誌. 30(6). 1374-1383 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 埴英郎,松村光明,井上昌幸: "歯冠修復用金属の口腔内における表面変化の観察-第1報 X線マイクロアナライザによる分析の制度とその応用-" 口腔病学会雑誌. 56(4). 465-472 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 井上昌幸,埴英郎,南孝: "歯科用金属の口腔内における腐食性変化と基礎的試験法について" DE. 95. 35-40 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 浜野英也: "歯科用金属の生体に与える影響に関する基礎的研究-ニッケルの溶出ならびに培養細胞における毒性と経時的動態-" 口腔病学会雑誌. 59. 456-478 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 井上昌幸: "金属アレルギーの現状と歯科領域における対応" 日本補綴歯科学会雑誌. 37. 1127-1138 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 井上昌幸,中山秀夫 編: "歯科と金属アレルギー" デンタル ダイヤモンド, 197 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitsuaki Matsumura: "Study on Methods to Evaluate Dental Casing Alloys. Part 1. Observation on Changes of Metals in Immersion Tests." J Jpn Prosthodont Soc. 30. 1198-1209 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitsuaki Matsumura: "Study on Methods to Evaluate Dental Casting Alloys. Part 2. Relation Between Subcutanious Implant Test and Immersion Test." J Jpn Prosthodont Soc. 30. 1374-1383 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hideo Hani, Mitsuaki Matsumura and Masayuki Inoue: "Surface Changes of Dental Alloys in Oral Environment. Part 1. Accuracy of EPMA Analysis and its Applicability to Estimate Corrosion of Dental Alloys." J Stomatol Soc Jpn. 56. 456-472 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masayuki Inoue, Hideo Hani and Takashi Minami: "Corrosive Changes in the Mouth and Laboratory Tests of Dental Alloys" DE. 95. 35-40 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hideya Hamano: "Fundamental Studies on Biological Effects of Dental Metals -Nickel Dissolution, Toxicity and Distribution in Cultured Cells-" J Stomatol Soc Jpn. 59. 456-478 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masayuki Inoue: "The Status Quo of the Metal Allergy and the Measures Against it in Dentistry" J Jpn Prosthodont Soc.37. 1127-1138 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masayuki Inoue and Hideo Nakayama (eds.): "Dentistry and Metal Allergy" Dental Diamond, Tokyo. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noriko Suzuki: "Studies on Metal Allergy in the Field of Dentistry -Treatment with Application of X-ray Fluorescence Spectroscope Analysis in Detection of Allergen Metals-" J Stomatol Soc Jpn. 61. 144-158 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noriko Suzuki: "Metal Allergy in the Field of Dentistry -Detection of Allergen Metals with X-ray Fluorescence Spectroscope, and its Application towards Allergen Elimination-" Int J Prosthodont. (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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