1991 Fiscal Year Final Research Report Summary
Catalytic Asymmetric Synthesis of Biologically Important Molecules
| Project/Area Number |
02453137
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
SHIBASAKI Masakatsu Hokkaido Univ.Fac.Pharamac.Sci・Professor, 薬学部, 教授 (30112767)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Yoshihiro Hokkaido Univ.Fac.Pharmac.Sci・Instructor, 薬学部, 教務職員 (90226019)
SASAI Hiroaki Hokkaido Univ.Fac.Pharmac.Sci・Instructor, 薬学部, 助手 (90205831)
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| Project Period (FY) |
1990 – 1991
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| Keywords | Heck Reaction / Catalytic Asymmetric Synthesis / Decalin Derivatives / Hydrindan Derivatives / Capnellenol / Marine Natural Product |
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| Research Abstract |
Previously we developed an asymmetric Heck reaction, in which the cis-decalin derivative was obtained in 45% ee. Now we have succeeded in improving the above-mentioned asymmetric Heck reaction as shown below.
Furthermore, we have accomplished a catalytic asymmetric synthesis of capnellenols 5 and 6 by utilizing an asymmetric Heck reaction. On the other hand, the cis-decalin derivative 7 has been found to be synthesized in 83% ee through the pi-allylpalladium intermediate.
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