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1992 Fiscal Year Final Research Report Summary

Emissary venous flow and selective brain cooling in hyperthermic human subjects.

Research Project

Project/Area Number 02454128
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionKanazawa University

Principal Investigator

NAGASAKA Tetsuo  Kanazawa University School of Medicine, Professor, 医学部, 教授 (80023646)

Co-Investigator(Kenkyū-buntansha) HIRASHITA Masami  Kanazawa College of Economics, Professor, 教授 (30102007)
SAKURADA Sohtaro  Kanazawa University School of Medicine, Instructor, 医学部, 助手 (00215691)
TANABE Minoru  Kanazawa University School of Medicine, Instructor, 医学部, 助手 (20217110)
OSHIDO Osamu  Kanazawa University School of Medicine, Associate Professor, 医学部, 助教授 (40175386)
Project Period (FY) 1990 – 1992
KeywordsHyperthermia / Passive Body Warming / Exercise / Selective brain Cooling / Emissary veins / Sweating / Body Posture Change
Research Abstract

We measured skin blood flow and sweating rate of the head, blood flow in the angular oculi and mastoid emissary veins, esophageal, tympanic, and mean skin temperatures during whole body hyperthermia in male volunteers. 1. When angular oculi flow was obstructed for 8-10 min while core temperatures were still rising, the rate of rise in tympanic temperature increased than before but that in esophageal temperature did not change. When angular oculi flow was increased by skin compression over the facial veins at an alinasl level, the rate of rise in tympanic temperature decreased than before but esophageal temperature did not change. 2. Tympanic temperature at which a sharp increase of flow occurred in angular oculi veins was the same in either passive body warming or exercise. 3. Temperature difference between the esophagus and the tympanum [Tes-Tty] became less in the subjects with heavy make-up than in those without. 4. When body posture was changed from supine to a 30゚ head-up position, blood flows in angular oculi and mastoid emissary veins were increased with a fall in the rate of rise in tympanic temperature. When the subjects remained supine, [Tes-Tty] remained small for the entire period of whole body hyperthermia. 5. During body warming, mean skin temperature reached 37-38゚C and skin blood flow and sweating rate of the face reached a plateau even when core temperatures were still rising. We suggest that the fall in brain temperature by selective brain cooling would not suppress the heat loss responses as far as brain temperature is within the range of temperature at which the heat loss responsesare at their maximum level. From these results, we conclude that selective brain cooling is possible and important in humans. Selective brain cooling is achieved by inflow of venous blood, cooled on the scalp and face by evaporation of sweat, through the emissary and ophtahalmic veins into the intracranium.

  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Nagasaka,T.et al.: "Role of the veins of the face in brain cooling during body arming in human subjects." Jpn.J.Biometeor.27(3). 113-120 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirashita.M.et al.: "Blood flow through the ophthalmic veins during exercise in humans." Eur.J.Appl.Physiol.64. 92-97 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 平井 敦夫: "無風高温環境で頭部の熱移動におよぼす化粧の影響。" 宇宙航空環境医学. 30. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Brinnel.H. et al.: "The efficiency of selective brain cooling during hyperthermia in humans in upright versus supine position." Strahlenther.Onkol.166. 508 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 平下 政美: "ヒトの暑熱障害防止を目的とした選択的脳冷却機構の個人差の解明。" デサントスポーツ科学. 14. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagasaka,T.: "Letters to the editors:Influence of ventilation of the face on thermoregulation in man during hyper-and hypothermia." Eru.J.Appl.Physiol.64. 280 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirashsita,M.et al.: "Contributions of body core and mean skin temperatures to the control of forehead sweating rate in humans." Jpn.J.Bimeteor.30. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirashita,M.et al.: "Relationship between heat loss responses and body core temperatures during hyperthermia in humans." Jpn.J.Biometeor.30. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirai,A.et al.: "Enhancement of finger blood flow response of postprandial human subjects to the increase in body temperature during exercise." Eur.J.Appl.Physiol.62. 221-227 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 永坂 鉄夫: "温熱と疲労の応用生理。" 疲労と栄養の科学. 7(1). 1-4 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 永坂 鉄夫: "ハイパーサーミアーその生理と病態ー。" 日温気物医誌. 55(1). 13-15 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagasaka.T.et al.: "Heat-induced finger vasoconstriction controlled by skin sympathetic nerve activity." J.Appl.Physiol.68. 71-75 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 永坂 鉄夫: "動静脈吻合による皮膚での熱移動の調節。" 日本生理誌. 52. 197-205 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagasaka.T.: "Heat-induced skin vasoconstriction-A mechanism to retard heat gain through skin heated locally in hot environments." Environmental Med.34. 37-44 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagasaka,T. et al.: "Role of the veins of the face in brain cooling during body warming in human subjects." Jpn. J. Biometeor.27(3). 113-120 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirashita,M. et al.: "Blood flow through the ophthalmic veins during exercise in humans." Eur. J. Appl. Physiol.64. 92-97 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Brinnel,H. et al.: "The efficiency of selective brain cooling during hyperthermia in humans in upright versus supine position." Strahlenther. Onkol.166. 508 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Nagasaka: "Letters to the editors: Influence of ventilation of the face on thermoregulation in man during hyper- and hypothermia." Eur. J. Appl. Physiol.64. 280 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirashita,M. et al.: "Relationship between heat loss responses and body core temperatures during hyperthermia in humans." Jpn. J. Biometeor.30. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirashsita,M. et al.: "Contributions of body core and mean skin temperatures to the control of forehead sweating rate in humans." Jpn. J. Biometeor.30. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirai,A. et al.: "Enhancement of finger blood flow response of postprandial human subjects to the increase in body temperature during exercise." Eur. J. Appl. Physiol.62. 221-227 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagasaka,T. et al.: "Heat-induced finger vasoconstriction controlled by skin sympathetic nerve activity." J. Appl. Physiol.68. 71-75 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagasaka,T.: "Heat-induced skin vasoconstriction -A mechanism to retard heat gain through skin heated locally in hot environments." Environmental Med.34. 37-44 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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