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1992 Fiscal Year Final Research Report Summary

Study on new risk factors for prevention of stroke and coronary heart disease in uged populations

Research Project

Project/Area Number 02454209
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionUniversity of Tsukuba

Principal Investigator

SHIMAMOTO Takashi  U of Tsukuba, Institute of Community Medicine, Professor, 社会医学系, 教授 (50143178)

Co-Investigator(Kenkyū-buntansha) KONISHI Masamitsu  The National Cardiovascular Center, Director, 集検部, 部長
ISO Hiroyasu  U of Tsukuba, Institute of Community Medicine, Assistant Prof., 社会医学系(平成2年度のみ), 講師 (50223053)
KOIKE Kazuko  U of Tsukuba, Institute of Community Medicine, Assistant Prof., 社会医学系(平成2年度のみ), 講師 (60110508)
KOMACHI Yoshio  Osaka Research Institute of Public Health, President, 社会医学系(平成2年度のみ), 教授 (50134242)
Project Period (FY) 1990 – 1992
KeywordsFibrinogen / Fatty acids composition / Cerebral infarction / Coronary heart disease / Smoking / Fish intake
Research Abstract

1. We examined plasma fibrinogen for 8,142 men and women aged 40-69 years in six urban and rural populations to investigate constitutional and lifestyle variables of plasma fibrinogen. Mean plasma fibrinogen was higher with age, higher in women than in men, and higher in those with a lower fish intake than in those with a higher fish intake. The variation in population levels of plasma fibrinogen was partly, but not fully explained by differences in those environmental factors.
2. According to a comparative study of Japanese (n = 150) and US Caucasians (n =150), mean plasma fibrinogen was lower in Japanese than in Caucasians. The proportion of B2 allele on the beta-fibrinogen gene which was associated with higher plasma fibrinogen level, was higher in Caucasians than in Japanese.
3. The variation in population levels of tissue plasminogen activator and plasminogen activator inhibitor according to a preliminary study of six US and Japanese populations.
4. A nested case-control study was conducted among 13,425 urban men to examine the relation between serum fatty acid compositions with subsequent coronary heart disease. There were 26 coronary heart disease,and the control was matched for each case according to population, sex and age. According to conditional logistic regression, systolic blood pressure, serum total cholesterol, serum glucose and smoking were positively associated with coronary heart disease. HDL-cholesterol was inversely associated with coronary heart disease. Serum omega-3 fatty acids was inversely and omega-6 fatty acids was positively associated with coronary heart disease although not statistically significant. The result suggests that the effect of serum fatty acids on the development of coronary heart disease is smaller than that of conventional coronary risk factors. No association was found between serum fatty acids and cerebral infarction. Further follow-up will be conducted to confirm these associations.

  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] M.Konishi et.al:"Trends for Coronary Heart Disease and its Rick Factors in Japan:Epileniologic and Pathologic Studies" Jap Circulation J.54(4). 428-435 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 北村 明彦他: "脳卒中の発生状況の推移と脳梗塞の発生要因の変遷ー秋田農村における20年間の疫学調査成続よりー" 脳卒中. 12(4). 387-395 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Konishi et al:"Secular Trends in Atheroscherosis of Coronavy Arteries and Basal Cerebral Artories in Japan" Arteriosclerosis. 10(4). 535-540 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] 山海 知子他: "CT所見を中心とした脳卒中の疫学的研究ー農村集団における病型別にみた発生割合の検討ー" 日本公衆衛生雑誌. 38(12). 901-909 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山海 知子他: "CT所見を中心とした脳卒中の疫学的研究ーコホート内症例対照研究による脳出血脳梗塞の病型別発生要因の検討" 日本公衆衛生雑誌. 39(7). 410-420 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Shimamoto et al:"Trends in the incidence of cardiovascular diseases and their risk foators in a rural Japanese population" J.of Epidemiology(Suppl). 86(3). 1046-1060 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroyasu Iso, et al.: "Hemostatic variables in Japanese and Caucasian men, Tissue plosmirogen activator, antithronbin III and protein C, and their relations to coronary risk factors" American Journel of Epidemiology. 132. 41-46 (1990)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Utako Umemura, et al.: "Epidemiological study of fatty acids compositions in diet and serum for dietary recommen dations, Comparative study of women in populations with various dietary halrts" Japanese Jourenal of Hygiene.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Shimamoto, et al.: "Epidemiologic study on plasma fibrinogen and fibrinolytic voriables as risk factors of cardiovascular disease" Report of Special Research Project on Metabolism (IV). 79-83 (1992)

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      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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