1992 Fiscal Year Final Research Report Summary
Studies on etiology of pulmonary hypertension in collagen disease
| Project/Area Number |
02454221
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
内科学一般
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| Research Institution | Fukushima Medical College |
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Principal Investigator |
KASUKAWA Reiji Fukushima Medical College, 第二内科, 教授 (80045632)
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| Co-Investigator(Kenkyū-buntansha) |
KANNO Takashi Fukushima Medical College, 第二内科, 助手 (60234168)
MIYATA Masayuki Fukushima Medical College, 第二内科, 助手 (40219788)
NISHIMAKI Tomoe Fukushima Medical College, 第二内科, 助教授 (00128555)
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| Project Period (FY) |
1990 – 1992
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| Keywords | Pulmonary hypertension / collagen disease / anti-cardiolipin antibody / von Willebrand factor antigen / anti-nRNP antibody / Monocrotaline-induced rat pulmonary hypertension / cytokine / human endothelial cells |
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| Research Abstract |
1.Pulmonary hypertension with mean pulmonary pressure more than 25mmHg was noted in 10 of 12 patients with collagen disease carrying anti-cardiolipin anti-body but only in 1 of 11 patients with collagen disease not carrying anti-cardiolipin antibody.
2.Serum level of von Willebrand factor antigen was elevated more at 261.8% (mean value) in 5 patients with mixed connective tissue disease (MCTD) associated with pulmonary hypertension (PH) than the level of146.1% in 21 patients with MCTD without PH.
3. Sera of patients with collagen disease carrying anti-nRNP antibody or anti-cardiolipin antibody contained IgG which react to the cultured human endothelial cells.
4. Sera of patients with MCTD carrying anti-nRNP antibody enhanced the adhesion of human T cells to the cultured human endothelial cells.
5. Alveolar macrophage from the monocrotaline-induced pulmonary hypertension rats excreted the increased level of IL-1, IL-6, and TNF in culture supernatant.
6. Human IL-1, 1IL-6, and TNF did not affect the proliferation of the cultured human endothelial cells but enhanced the proliferation of rat pulmonary fibro-blasts.
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