1992 Fiscal Year Final Research Report Summary
Histologic study of cellular response to graft material on hybrid-type vascular prosthesis.
| Project/Area Number |
02454296
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | University of Tokyo |
|---|
Principal Investigator |
SATO Osamu Tokyo Uni., Surgery, Director, 医学部(病), 助手 (40170724)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Akira Tokyo Uni., Surgery, Associate, 医学部(病), 助手 (00233099)
SHINDO Shyunya Tokyo Uni., Surgery, Associate, 医学部(病), 助手 (50206322)
SHIRAKAWA Motoaki Tokyo Uni., Surgery, Associate, 医学部(病), 助手 (20211295)
EGAMI Jyun Tokyo Uni., Surgery, Associate, 医学部(病), 助手 (80232932)
|
|---|
| Project Period (FY) |
1990 – 1992
|
| Keywords | endothelial cell seeding / prelined graft / hybrid-type vascular prosthesis / small caliber vascular prosthesis / endothelial cell / Endothelial Cell Seeding / Predined graft |
|---|
| Research Abstract |
A small caliber vascular prosthesis remains unsatisfactory in regard with the long term patency rate. A hybrid vascular prosthesis has been investigated for achieving the better patency in the way of combining the living cells with a synthetic graft. We studied the endothelial cells (ECs) seeding to the ultrafine polyester fiber grafts and developed the filtration seeding method in order to utilize a large number of cells. The in vitro and in vivo study revealed that the ECs grew up around the grafts with time and maintain the continuous monolayer of the ECs three months after implantation. However, at the anastomotic sites, the ECs monolayer was formed on the thick subendothelial tissue which continued to the thick intima of the host artery. The ECs seeding only may not be enough to prevent the graft failure. The intimal hyperplasia may be the major target for achieving the better patency of the small caliber vascular prosthesis in the following research.
|
-
-
-
-
[Publications] Atsuhiro,T,Motoaki,S,Shunya,S,Akira,O,Tetsuro,M,Jyun,E,Takatoshi,F,Yutaka,T,Osamu,S,Yusuke,T,Yasuo,I,Tetunoske,K: "Hybrid vascular prosthesis." Artifical Organ.19. 1064-1068 (1990)
Description
「研究成果報告書概要(和文)」より
-
[Publications] Motoaki,S,Shunya,S,Tetsuro,M,Jyun,E,Yutaka,T,Osamu,S,Atsuhiko,T,Yusuke,T,Yasuo,I,Shyoji,N,Moto,K,: "Animal experiment of the endothelial Seeding graft by filtration method." Artifical Organ. 19. 1297-1300 (1990)
Description
「研究成果報告書概要(和文)」より
-
[Publications] Shunya,S,Motoaki,S,Tetsuro,M,Jyum,E,Yutaka,T,Osamu,S,Atsuhiko,T,Yusuke,T,Yasuo,I: "A small caliber prosthes made of ultrafine polyester fibers seeded with autogenous endothelial cells by filration method." Artificial Organ. 19. 1361-1364 (1990)
Description
「研究成果報告書概要(和文)」より
-
[Publications] Atsuhiko,T,Motaki,S,Shunya,S,Akira,O,Tetsro,M,Jyun,E,Takatoshi,F.,Yutaka,T,Osamu,S: "Hybrid vascular prosthesis.(in Japanese)" Artificial Organ. 19. 1064-1068 (1990)
Description
「研究成果報告書概要(和文)」より
-
[Publications] Motoaki,S,Shunya,S,Tetsuro,M,Jyun,E,Yutaka,T.,Osamu,S,Atsuhiko,T,Yusuke,T: "Animal experiment of the endothelial seeding graft by filtration method.(in Japanese)" Artificial Organ.19. 1297-1300 (1990)
Description
「研究成果報告書概要(和文)」より
-
[Publications] Atsuhiko Takagi, Motoaki Shirakawa, Shunya Shindo, Akira Oshima, Tetsuro Miyata, Jyun Egami, Takatoshi Furuya, Yutaka Takayama, Osamu Sato, Yusuke Tada, Yasuo Idezuki, Tetunasuke Kunitomo: "Hybrid vascular prosthesis. (in Japanese)" Artificial Organ. 19. 1064-68 (1990)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Motoaki Shirakawa, Shunya Shindo, Tetsuro Miyata, Jyun Egami, Yutaka Takayama, Osamu Sato, Atsuhiko Takagi, Yusuke Tada, Yasuo Idezuki, Shyoji Nagaoka, Moto Kurumatani: "Animal experiment of the endothelial seeding graft by filtration method. (in Japanese)" Artificial Organ. 19. 1297-1300 (1990)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Shunya Shindo, Motoaki Shirakawa, Tetsuro Miyata, Jyun Egami, Yutaka Takayama, Osamu Sato, Atsuhiko Takagi, Yusuke Tada, Yasuo Idezuki, Shyoji Nagaoka, Moto Kurumatani: "A small caliber prosthesis made of ultrafine polyester fibers seeded with autogenous endothelial cells by filtration method. (in Japanese)" Artificial Organ. 19. 1361-64 (1990)
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
